• 제목, 요약, 키워드: ethnopharmacology

검색결과 43건 처리시간 0.03초

In vitro Antioxidant Activity of Ethanolic Extract of Chlorophytum borivilianum

  • Govindarajan, R.;Sreevidya, N.;Vijayakumar, M.;Thakur, M.;Dixit, V.K.;Mehrotra, S.;Pushpangadan, P.
    • Natural Product Sciences
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    • v.11 no.3
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    • pp.165-169
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    • 2005
  • Chlorophytum borivilianum Baker (Antharicaceae) commonly referred as 'Safed Musli' has been widely used in the Indian traditional systems of medicine to treat various diseases like rheumatism apart from having immunomodulating property and is used as general tonic. It is also known as 'Ayurvedic viagra' for its aphordisiac properties. C. borivilianum was screened for the first time to determine its antioxidant activity, isolation of the sapogenins and standardization of the isolated sapogenin fraction using HPTLC. Potent antioxidant activity of ethanolic extract was found by their ability to scavenge DPPH (84.51%), hydroxyl radical (48.95 %), ferryl bi-pyridyl complex (84.53%) along with the inhibition of lipid peroxidation (67.17%) at $100\;{\mu}g/ml$ concentration. The ethanolic extract also exhibited significant inhibition of superoxide anion radical generated by photochemiluminescence. Thus, the potent antioxidant activity validates the innumerable therapeutic claims of the plant in the traditional system especially its use as a Rasayana drug.

Neuropharmacological study of some Ayurvedic medicinal plants

  • Hannan, JMA;Shahriar, Masum;Islam, M Naimul;Sattar, Mafruhi;Haque, Sabera;Choudhuri, MSK
    • Oriental Pharmacy and Experimental Medicine
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    • v.3 no.1
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    • pp.8-17
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    • 2003
  • Water extract (kwath) of six different widely used Ayurvedic medicinal plants were tested in mice for possible neuropharmacological efficacy. In the present experiments it was observed that a number of plant tested causes a significant level of Central Nervous System (CNS) depression, in that it significantly decreased the spontaneous Motor activity, and also lowered the exploratory behavior of the treated animals. Terminalia chebula (HAA), Terminalia bellerica (BHA), Emblica officinalis (AA), Piper longum 1. (PP). exhibited depressant action of on the CNS. Apart from them a mild to moderate degree of depression was evident as a consequence of administration of Zingiber officinale Rosc (SUT), Piper nigrum L. (MRC). However, none of the plant tested did not exhibit significant effects on pentobarbital induced narcosis, and this indicated that the sedating effects of the drug was not associated with the risk of fatal consequences on overdose.

A psycho-pharmacological study of BRHAT VATACINTAMANI RASA classical ayurvedic drug

  • Islam, M. Naimul;Sattar, Mafruhi;Haque, Sabera;Shahriar, Masum;Choudhuri, Msk
    • Oriental Pharmacy and Experimental Medicine
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    • v.3 no.2
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    • pp.63-71
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    • 2003
  • The psycho-pharmacological effect of BRHAT VATACHINTAMANI RASA (BVC) an Ayurvedic preparation was investigated, both in animal and clinical models. It was observed that BVC possess a sedative or quitening effect in that it significantly decreased the spontaneous motor activity, and also lowered the exploratory behavior of the amphetamine treated animals. This was further evident by increase in climbing out time and taming effect on animal in isolation induced aggression test. Apart from very high dose it seems have little effect on pentobarbital sleeping time and narcotic analgesic test. The drug BVC increases performance of the animal in forced locomotor test. The effect of VATACHINTAMANI RASA on clinical study was not significant.

Ethnopharmacological Evaluation of Peristrophe bicalyculata Nees. for Anti-inflammatory and Analgesic Activity

  • Rathi, Anshu;Rao, Ch.V.;Khatoon, S.;Mehrotra, S.
    • Natural Product Sciences
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    • v.9 no.3
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    • pp.195-199
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    • 2003
  • The ethanolic (50% v/v) extracts of Peristrophe bicalyculata Nees. (Acanthaceae) were examined for anti-inflammatory and analgesic activities in experimental animals. P. bicalyculata in doses of 50, 100 and 200 mg/kg caused a dose dependent inhibition of swelling caused by carrageenin equivalent to 12.25-24.49% protection and 16.62-39.44% in cotton pellet induced granuloma in rats. There was a significant increase in the tail-flick reaction time in mice (18.05-76.43% protection) and analgesy-meter induced pain in rats (14.49-56.85%) protection). The extract of P. bicalyculata resulted in an inhibition of stretching episodes and the protection range of 14.49-56.85% respectively in acetic acid induced writhing.

Pharmacognostic Evaluation of the Roots of Berberis chitria Lindl.

  • Srivastava, Sharad Kumar;Rawat, Ajay Kumar Singh;Srivastava, Manjoosha;Mehrotra, Shanta
    • Natural Product Sciences
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    • v.12 no.1
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    • pp.19-23
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    • 2006
  • Berberis chitria (family Berberidaceae) has a close affinity with B. aristata, used in traditional systems of medicine as a drug 'Daruharidra' for skin disease, jaundice, affection of eyes, and rheumatism. Keeping this in view, in the present study attempts have been made to identify marker characters of B. chitria in order to differentiate the two species. Some of the diagnostic features of the root are patches of pericyclic fibre, pitted sclerieds and berberine containing cells and heterocyclic medullary rays. Besides, the physicochemical characters such as total ash; acid insoluble ash; alcohol and water soluble extractive; tannins; sugar and starch percentages has shown variations. The percentage of berberine as berberine hydrochloride was also calculated through HPTLC densitometric method and it was found little higher than B. aristata and B. asiatica i.e. 3.16%. Thus, this species can be utilized as a possible substitute to Daruharidra.

Pharmacognostical Evaluation and Phytochemical Standardization of Abrus precatorius L. Seeds

  • Verma, Durgesh;Tiwari, Shashi Shankar;Srivastava, Sharad;Rawat, A.K.S.
    • Natural Product Sciences
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    • v.17 no.1
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    • pp.51-57
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    • 2011
  • The seeds of Abrus precatorius L. (Family- Fabaceae) constitute the drugs Abrus, Gunja, or Ratti in commerce. In the Indian System of Medicine, the seeds are used for sciatica, paralysis, headache, dysentery, diarrhoea, leprosy, ulcer, nervous disorders, alopecia, as well as anti-inflammatory, antidiabetic, antibacterial, antitumor, sexual stimulant and abortifacient. Seeds are poisonous and therefore are used after mitigation. The protein abrin is responsible for the highly toxic properties of seeds. Quantitative HPTLC analysis of the methanolic extract of seeds determined the presence of 0.4018% gallic acid and 0.4009% glycyrrhizin. The present study was undertaken to develop an HPTLC method, as well as ascertain the physico-chemical, morphological and histological parameters to establish the authenticity of A. precatorius seeds.

Pharmacognostic Evaluation of Curcuma caesia Roxb. rhizome

  • Verma, Durgesh;Srivastava, Sharad;Singh, Vineet;Rawat, A.K.S.
    • Natural Product Sciences
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    • v.16 no.2
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    • pp.107-110
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    • 2010
  • Curcuma caesia Roxb. (Zingiberaceae) is commonly known as 'Black turmeric'. In India it grows in West Bengal, Madhya Pradesh, Orissa, Bihar, North-East and Uttar Pradesh and is widely used by ethnic communities for various ailments. Rhizomes of the plant are used for sprains and bruises and are also employed in cosmetics. In West Bengal it is an important place in traditional system of medicine and is also used as a substitute for turmeric in fresh stage. Present communication deals with the detailed pharmacognostical evaluation of the rhizome sample. Inner part of the rhizome is bluish-black in colour and emits a characteristic sweet smell, due to the presence of essential oil. On steam distillation the rhizome yields an essential oil rich in camphor. A detailed HPTLC studies has been carried out for quantitative evaluation of active marker component. HPTLC, physico-chemical, morphological and histological parameters presented in this paper may be proposed as parameters to establish the authenticity of C. caesia rhizome and may possibly help to differentiate the drug from its other allied species.

High-Performance Liquid Chromatographic Method for Quantitative Estimation of an Antioxidant Principle Chlorogenic Acid in Saussarea costus and Arctium lappa

  • Pandey, Madan Mohan;Govindarajan, Raghavan;Rawat, Ajay Kumar Singh;Pangtey, Yashpal Singh;Mehrotra, Shanta
    • Natural Product Sciences
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    • v.10 no.1
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    • pp.40-42
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    • 2004
  • A simple quantitative HPLC method has been developed for differentiating two plants of Asteraceae family viz. S. costus and A. lappa by using a pharmacologically active constituent chlorogenic acid and symmetry C18 column clubbed with a binary gradient using acetonitrile: 0.1% phosphoric acid and detected using a PDA at 327 nm. Quantitatively chlorogenic acid was found to be more in A. lappa (0.140%) than in S. costus (0.087%).

Pharmacognostic Evaluation of Pipper longum Linn. Fruit

  • Gupta, Meenu;Srivastava, Sharad;Mehrotra, Shanta;Sharma, Vinita;Rawat, AKS;Srivastava, Manjoosha
    • Natural Product Sciences
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    • v.13 no.2
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    • pp.97-100
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    • 2007
  • The present study includes macro and microscopical details, powder study, physico-chemical study and HPTLC fingerprinting of the Piper longum fruits. Microscopic studies revealed the presence of stone cells, starch grains and thin walled fragments of parenchymatous cells. Physico-chemical studies showed alcohol and ether soluble extract 24.53 and 6.7, sugar 0.35, starch 21.33 and tannin 0.83% respectively. Successive soxhlet extract showed maximum percentage of hexane soluble fraction i.e. 22.52. The HPTLC profile has also been performed against the reference marker pipeline, which was identified at R$_f$ 0.42. In the present paper a detailed pharmacognostical evaluation of fruit has been undertaken.

Quercetin, A Bioflavonoid, Protects Against Oxidative Stress-related Gastric Mucosal Damage in Rats

  • Rao, Ch.V.;Ojha, S.K.;Govindarajan, R.;Rawat, A.K.S.;Mehrotra, S.;Pushpangadan, P.
    • Natural Product Sciences
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    • v.9 no.2
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    • pp.68-72
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    • 2003
  • Quercetin and its sugar conjugates are the most abundantly distributed bioflavonoids and represent the largest proportion of flavonols in the plant kingdom. The present study was undertaken to demonstrate the effect of quercetin on the role of reactive oxygen species (ROS) in the development of gastric ulcers in rats. Administration of quercetin in doses of 50, 100 and $200\;mg\;kg^{-1}$ twice daily for 5 days, showed dose dependent significant protection against ethanol (EtOH), aspirin (ASP), cold-restraint stress (CRS) and pylorus ligation (PL) -induced gastric ulcer models and the results were comparable with those elicited by sucralfate. The thiobarbituric acid reactive substances in the stomach mucosa, an index of lipid peroxidation and regulation of plasma corticosterone were significantly increased in CRS-induced gastric ulceration. The queroetin $(100\;mg\;kg^{-1})$ and reduced glutathione effectively inhibited gastric lesions induced by CRS with a significant decrease in the lipid peroxidation and plasma corticosterone. These results indicate that quercetin a bioflavonoid exerts its antiulcer effect in light of free radical scavenging and plasma corticosterone in cold restraint stress ulcers.