• 제목, 요약, 키워드: ethnopharmacology

검색결과 43건 처리시간 0.047초

Constituents of Mallotus nepalensis Muell. Arg.: a Mild CNS Depressant

  • Rastogi, Subha;Mehrotra, Bishen Narain;Kulshreshtha, Dinesh K.
    • Natural Product Sciences
    • /
    • v.10 no.5
    • /
    • pp.237-239
    • /
    • 2004
  • Mallotus nepalensis (Euphorbiaceae) is a small tree found in central and eastern Himalayas, Nepal, Wallich and Sikkim. The 90% ethanolic extract of Mallotus nepalensis exhibited mild CNS depressant activity. Four compounds, lupeol (1), ${\beta}-sitosterol$ (2), ursolic acid (3) and ${\beta}-sitosterol-\;{\beta}-D-glucoside$ (4) were isolated from the 90% ethanolic extract of this plant of which 1, 3 and 4 are being reported for the first time from this species.

Seasonal Variation Studies and Pharmacognostic Evaluation of Alstonia scholaris R.Br. Bark

  • Upadhye, A.S.;Khatoon, Sayyada;Mehrotra, Shanta
    • Natural Product Sciences
    • /
    • v.12 no.4
    • /
    • pp.241-246
    • /
    • 2006
  • Alstonia scholaris is known as 'Saptaparna' in Ayurvedic System of Medicines and the bark is used for the treatment of various diseases. It has various ethnomedicinal values as different traditional communities find diverse medicinal properties. The present communication deals with the seasonal variation studies of the stem bark of this plant. The bark was collected in the month of January, July and November. There is no macro-microscopical changes in all the three seasons but the ash values showed significant differences. Crude fibre content showed sharp decline from January to July to November. Total tannin percentage was found maximum in January and minimum in June. TLC finger print profile showed more concentration of constituents in January as compared to June and November. Hence, the bark may show more efficacy when collected in January.

Molecular Mechanism of Inflammatory Signaling and Predominant Role of Saposhnikovia divaricata as Anti-inflammatory Potential

  • Khan, Salman;Kim, Yeong Shik
    • Natural Product Sciences
    • /
    • v.19 no.2
    • /
    • pp.120-126
    • /
    • 2013
  • Natural products have always been a pivotal source of new drug development. Dry roots of Saposhnikovia divaricata (Turcz.) Schischk. (Umbelliferae) is a perennial herb and is also known as Bang Pung in traditional medicine. Numerous in vitro and in vivo studies have revealed the diverse pharmacological effects of S. divaricata and its role in the treatment of various diseases. This herb has exhibited significant inhibitory effects against inflammation and associated disorders. The present study explored the ethnopharmacological applications and molecular mechanisms behind the anti-inflammatory effects of S. divaricata herb and a single compound blockade of multi-signaling inflammatory cascades. Taken together, this review provides insight into the potential role of S. divaricata against various inflammatory diseases.

Traditional uses, phytochemistry and pharmacology of Bauhinia racemosa Lam - a review

  • Soni, Vishal;Jha, Arvind Kumar;Dwivedi, Jaya;Soni, Priyanka
    • 셀메드
    • /
    • v.5 no.4
    • /
    • pp.24.1-24.7
    • /
    • 2015
  • Bahunia racemosa family, Caesalpiniaceae, is one of the precious resources of the earth. It has played a significant role in human civilization since ancient times. It is tall sized tree growing throughout India, Ceylon, China, and Timor. The different part of this plant contains β-sitosterol and β-amyrin, flavonols (kaempferol and quercetin) and two coumarins (scopoletin and scopolin), tannins etc. Various part of this plant has great pharmacological potential with a great utility and usage as folklore medicine as analgesic, antipyretic, anti-inflammatory, antispasmodic and antimicrobial activity. This review mainly focus on the exclusive review work on the traditional, phytochemical and pharmacological activities of this plant.

Ethnopharmacology, bioactivities and chemical constituents of some anti-cancer plants in Malaysia

  • Chooi, Ong-Hean
    • 한국자원식물학회:학술대회논문집
    • /
    • /
    • pp.90-109
    • /
    • 1999
  • Many plant species are used in Malaysia in folk medicine for the treatment of cancer. This paper presents some of these species with details on other ethnopharmacological uses, the known bioactivities and some chemical constituents of each of the species given. It is normal practice in traditional medicine that one species of plant is used to treat various ailments. Thus the plant species listed are all used to treat cancer but have various other ethnophrmacological uses as well, some with few other uses and rest with many other uses. Information on bioactivities of each species resulting from tests on human and experimental animals are also given. Proven bioactivities give strength to ethnopharmacological claims on the efficacies of plant resources in the treatment of cancer and various other ailments but will but will not necessarily lead to the production of new pharmaceutical drugs. Many of the known chemical constituents of each species are given. This shows the richness and variety of chemicals containes in each of the species listed, The chemicals listed may or may not prove to be important in the pharmaceutical sciences but is an indication of what each species contatin in thrms of plant chemicals, It is a well known fact that many of the pharmaceutical prescriptions in present day use are of plant origin and semi-synthetic or fully synthetic chemicals produced using knowledge gained from studies of phytochemicals. Thus the paper presented will give useful information and also shows the richness of plant species that have high potentials for the development of anti-cancer resources from plants in Malaysia.

  • PDF

Ethnopharmacology, bioactivities and chemical constituents of some anti-cancer plants in Malaysia

  • Chooi, Ong-Hean
    • Plant Resources
    • /
    • v.3 no.1
    • /
    • pp.46-58
    • /
    • 2000
  • Many plant species are used in Malaysia in folk medicine for the treatment of cancer. This paper presents some of these species with details on other ethnopharmacological uses, the known bioactivities and some chemical constituents of each of the species given. It is normal practice in traditional medicine that one species of plant is used to treat various ailments. Thus the plant species listed are all used to treat cancer but have various other ethnophrmacological uses as well, some with few other uses and rest with many other uses. Information on bioactivities of each species resulting from tests on human and experimental animals are also given. Proven bioactivities give strength to ethnopharmacological claims on the efficacies of plant resources in the treatment of cancer and various other ailments but will but will not necessarily lead to the production of new pharmaceutical drugs. Many of the known chemical constituents of each species are given. This shows the richness and variety of chemicals containes in each of the species listed. The chemicals listed may or may not prove to be important in the pharmaceutical sciences but is an indication of what each species contatin in thrms of plant chemicals. It is a well known fact that many of the pharmaceutical prescriptions in present day use are of plant origin and semi-synthetic or fully synthetic chemicals produced using knowledge gained from studies of phytochemicals. Thus the paper presented will give useful information and also shows the richness of plant species that have high potentials for the development of anti-cancer resources from plants in Malaysia.

  • PDF

Beneficial Antioxidative and Antiperoxidative Effect of Cinnamaldehyde Protect Streptozotocin-Induced Pancreatic β-Cells Damage in Wistar Rats

  • Subash-Babu, P.;Alshatwi, Ali A.;Ignacimuthu, S.
    • Biomolecules & Therapeutics
    • /
    • v.22 no.1
    • /
    • pp.47-54
    • /
    • 2014
  • The present study was aimed to evaluate the antioxidant defense system of cinnamaldehyde in normal, diabetic rats and its possible protection of pancreatic ${\beta}$-cells against its gradual loss under diabetic conditions. In vitro free radical scavenging effect of cinnamaldehyde was determined using DPPH (1,1-diphenyl-2-dipicrylhydrazyl), superoxide radical, and nitric oxide radical. Streptozotocin (STZ) diabetic rats were orally administered with cinnamaldehyde at concentrations of 5, 10 and 20 mg/kg body weight for 45 days. At the end of the experiment, the levels of plasma lipid peroxides and antioxidants such as vitamin C, vitamin E, ceruloplasmin, catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase were determined. A significant increase in the levels of plasma glucose, vitamin E, ceruloplasmin, and lipid peroxides and significant decrease in the levels of plasma insulin and reduced glutathione were observed in the diabetic rats. Also the activities of pancreatic antioxidant enzymes were altered in the STZ-induced diabetic rats. The altered enzyme activities were reverted to near-normal levels after treatment with cinnamaldehyde and glibenclamide. Histopathological studies also revealed a protective effect of cinnamaldehyde on pancreatic ${\beta}$-cells. Cinnamaldehyde enhances the antioxidant defense against reactive oxygen species produced under hyperglycemic conditions and thus protects pancreatic ${\beta}$-cells against their loss and exhibits antidiabetic properties.

Primary Pharmacological and Other Important Findings on the Medicinal Plant "Aconitum Heterophyllum" (Aruna)

  • Paramanick, Debashish;Panday, Ravindra;Shukla, Shiv Shankar;Sharma, Vikash
    • 대한약침학회지
    • /
    • v.20 no.2
    • /
    • pp.89-92
    • /
    • 2017
  • Aconitum Heterophyllum (A. Heterophyllum) is an indigenous medicinal plant of India and belongs to the family Ranunculaceae. A. Heterophyllum is known to possess a number of therapeutic effects. For very ancient times, this plant has been used in some formulations in the traditional healing system of India, i.e., Ayurveda. It is reported to have use in treating patients with urinary infections, diarrhea, and inflammation. It also has been used as an expectorant and for the promotion of hepatoprotective activity. The chemical studies of the plant have revealed that various parts of the plant contain alkaloids, carbohydrates, proteins and amino acids, saponins, glycosides, quinones, flavonoids, terpenoids, etc. In the present study, a comprehensive phytochemistry and pharmacognosy, as well as the medicinal properties, of A. Heterophyllum are discussed. Scientific information on the plant was collected from various sources, such as electronic sources (Google scholar, Pubmed) and some old classical text books of Ayurveda and Ethnopharmacology. The study also presents a review of the literature on A. Heterophyllum, as well as the primary pharmacological and other important findings on this medicine. This review article should provide useful information to and be a valuable tool for new researchers who are initiating studies on the plant A. Heterophyllum.

한국산 자생 수목 유래 수피추출물의 종양괴사인자 억제효과 (Inhibitory Effect of Extracts from Woody Plants on Tumor Necrosis $Factor-{\alpha}$ Production in Lipopolysaccharide-Stimulated RAW264.7 cells)

  • 조재열
    • 한국약용작물학회지
    • /
    • v.15 no.4
    • /
    • pp.271-275
    • /
    • 2007
  • Naturally occurring substances are important biomedical resources with low toxicity and ethnopharmacology-based efficacy. Four out of 45 extracts (Celastrus orbiculatus, Cercis chinensis, Stephanadra incisa, and Weigela subsessilis) prepared from the bark of Korea Forest plants exhibited more than 50% of inhibition on $TNF-{\alpha}$ production in lipopolysaccharide (LPS)-activated RAW264.7 cells at $100\;{\mu}g/m{\ell}$. In particular, potential inhibitory components of 4 extracts showed more than 50% inhibition seemed to be concentrated in methylene chloride (MC) fraction from C. orbiculatus, in ethyl acetate (EtOAc) fraction from C. chinensis and in hexane (Hx) fraction from S. incisa, whereas inhibitory activities of W. subssilis were broadly seen in non-polar solvent fractions such as Hx, MC and EtOAc. Therefore, our results suggest that extracts from C. orbiculatus, C. chinensis, S. incisa and W. subsessilis may be developed as a therapeutic remedy against $TNF-{\alpha}-mediated$ diseases such as rheumatoid arthritis or further fractionated to isolate active components having $antiTNF-{\alpha}$ inhibitory activity.

Loranthus ferrugineus: a Mistletoe from Traditional Uses to Laboratory Bench

  • Ameer, Omar Z.;Salman, Ibrahim M.;Quek, Ko Jin;Asmawi, Mohd. Z.
    • 대한약침학회지
    • /
    • v.18 no.1
    • /
    • pp.7-18
    • /
    • 2015
  • Objectives: Loranthus ferrugineus (L. ferrugineus) from Loranthaceae, a mistletoe, is a medicinal herb used for a variety of human ailments. Traditionally, decoctions of this parasitic shrub have been mainly used to treat high blood pressure (BP) and gastrointestinal complaints; usage which is supported by experimental based pharmacological investigations. Nonetheless, there is still limited data available evaluating this plant's traditions, and few studies have been scientifically translated toward evidence based phytomedicine. We therefore provide a concise review of the currently available L. ferrugineus literature and discuss potential directions for future areas of investigation. Methods: We surveyed available literature covering ethnopharmacological usage of L. ferrugineus and discussed relevant findings, including important future directions and shortcomings for the medicinal values of this parasitic shrub. Results: Evidence based pharmacological approaches significantly covered the medicinal application of L. ferrugineus for hypertension and gastrointestinal complaint management, with a particular focus on the active hydrophilic extract of this herb. Conclusion: Understanding the sites of action of this plant and its beneficial effects will provide justification for its use in old traditional treatments, and potentially lead to the development of therapies. Other medicinal applicative areas of this parasitic shrub, such as wound healing, gerontological effects, and antiviral and anticancer activities, are yet to be researched.