• Title, Summary, Keyword: fat accumulation

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Effect of Acanthopanacis Cortex Boiling Extract Solutions on Fat Accumulation in the Obese Rats Induced by High Fat Dietary (오갈피의 열수추출액이 고지방식이에 의한 비만유도 흰 쥐의 지방 축적에 미치는 영향)

  • Sung, Tae-Soo;Son, Gyu-Mok;Bae, Man-Jong;Choi, Cheong
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.21 no.1
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    • pp.9-16
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    • 1992
  • This study was carried out to evaluate the effect of Acanthopanacis Cortex boiling extract solutions on the fat accumulation in the obese rats induced by the oral high fat administration for six weeks. Total cholesterol, neutral fat and adipose acid of ACR groups were lower than the control group. During the feeding experiment, LDL and VLDL were increased while HDL was decreased in all groups. Insulin and cortisol were higher than the control group, due to the fat accumulation. Based on the above results, it was shown that it is possible to improve fat accumulation induced by high fat dietary through using the oral administration of Acanthopanacis Cortex boiling extract solutions.

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Different functions of visceral and subcutaneous fat cells

  • Saito, Yasushi
    • Proceedings of the Korean Society of Applied Pharmacology
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    • pp.29-34
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    • 2003
  • Visceral fat accumulation is known to be an evident clinical index for the insulin resistance related with obesity. Patients with excessive accumulation of visceral fat frequently suffered from metabolic disorder, such as hyperlipidemia, hypertension, and glucose intolerance. However, molecular mechanism for the pathogenesis of obesity-accompanied metabolic disorders has not been fully elucidated. It has been clarified that adipocytes in visceral fat area have different functions from subcutaneous fat area, and these differences might contribute the pathological significance of excessive accumulation of visceral fat for the accompanied insulin resistance and hyperinsulinemia.

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A Study on the Inhibitory Effects of Scutellariae Radix on Fat Accumulation (황금(黃芩, Scutellariae Radix)의 지방축적억제 효능연구)

  • Kim, Kyeong-Seon;Cha, Min-Ho;Lee, Soo-Won;Yoon, Yoo-Sik
    • Korean Journal of Oriental Medicine
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    • v.9 no.2
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    • pp.45-54
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    • 2003
  • Obesity is caused by unbalance of energy intake and expenditure, which results in extra accumulation of adipose tissue. Obesity is directly related to metabolic diseases such as diabetes, hyperlipidemia, fatty liver and so on. To investigate the anti-obesity effects of Scutellariae Radix, 70% EtOH extract and water extract of it were tested by in vitro and in vivo studies of fat accumulation. 3T3-L1 preadipocyte cell line was used in a in vitro study of fat accumulation. After 3T3-L1 cells were induced to differentiate into adipocytes, S. radix extract were added and fat accumulation was measured by oil red O staining. In vivo study showed that weight and epididymal/ retro-peritoneal adipose tissues were significantly reduced in mice fed Scutellariae Radix extract compared with control group. Especially, mice fed Scutellariae Radix extract showed reduced serum triglyceride and glucose levels. When adipose tissues were analyzed by microscope, mean adipocyte size was significantly reduced in Scutellariae Radix extract-fed mice. Therefore, this study showed inhibitory effects of Scutellariae Radix on in vitro and in vivo fat accumulation.

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The Relationship of Abdominal Obesity and Lipid Profiles by Computed Tomography in Adult Women (전산화 단층촬영을 이용한 성인여성의 복부비만과 지질대사지표와의 연관성)

  • Kim, Mi-Young
    • Journal of radiological science and technology
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    • v.31 no.1
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    • pp.33-39
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    • 2008
  • Abdominal obesity, especially, visceral obesity is thought to be a risk factor of type 2 diabetes and cardiovascular disease such as hypertension, hyperlipidemia, coronary artery disease. Based on previous studies visceral fat accumulation is highly related to these diseases compared to subcutaneous fat accumulation. The purpose of this study was to see the relation between abdominal obesity and lipid profiles in adult women. The included subjects were 25 adult women(BMI > $23\;kg/m^2$), who visited the obesity clinic in a general hospital from April 2006 to September 2007. Blood pressure, fasting glucose and lipid profiles were measured. The abdominal fat distribution had been assessed by CT scan at the level of L4-L5. From bivariate analyses, the visceral fat accumulation showed negative correlations with TC and TC/HDL. The BMI, total abdominal fat and Visceral fat/Subcutaneous fat ratio showed significant correlations with visceral fat accumulation. From linear regression analyses of all the study subjects, TC, TG and HDL were found to be determinants of the visceral fat accumulation($R^2\;=\;0.474$).

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Reduction of Fat Accumulation in Broiler Chickens by Sauropus Androgynus (Katuk) Leaf Meal Supplementation

  • Santoso, Urip;Sartini, Sartini
    • Asian-Australasian Journal of Animal Sciences
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    • v.14 no.3
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    • pp.346-350
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    • 2001
  • The present study was designed to evaluate the usefulness of Sauropus. androgynus leaf (SAL) meal on reducing fat accumulation in broiler chickens. Eighty unsexed broiler chickens were allocated to four treatment groups with five replicates of four chickens each. SAL meal supplementation had no effect on body, leg, back, breast, wing, liver and heart weights, carcass protein, moisture and ash contents (p>0.05). Broilers fed diets supplemented with 30 g of SAL meal had lower feed intake with better feed conversion ratio (p<0.05) than did the control chickens. SAL supplementation at all levels significantly reduced fat accumulation in abdomen region, and liver (p<0.01), and in carcass (p<0.05). Higher SAL supplementation resulted in lower fat accumulation in the carcass ($r^{2}=0.94$; p<0.01), abdomen ($r^{2}=0.99$; p<0.01) and liver ($r^{2}=0.98$; p<0.01). The current study showed that a 30 g supplementation of SAL meal to the broiler diet was effective to improve feed conversion ratio without reducing body weight. SAL meal supplementation to the diet reduce fat accumulation in broiler chickens.

Effect of Ginseng on Fat Accumulation in the Obese Rats Induced by High Fat Diet (인삼이 고지방식이에 의한 비만유도 Rat에서 지방축적에 미치는 영향)

  • 김신일;김영숙
    • Journal of Ginseng Research
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    • v.10 no.2
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    • pp.167-179
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    • 1986
  • Obesity is common disease resultly accumulated excess fat. In the model for obesity induced by high fat diet contains 30% fat, administration of ginseng extract inhibited increment of body weight, epididymal fat pads and enlargement of fat cell size. This was as the result of inhibition of lipogenesis in the liver and fat accumulation in the adipose tissues.

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Metabolic Activity of Desalted Ground Seawater of Jeju in Rat Muscle and Human Liver Cells

  • Kim, Bo-Youn;Lee, Young-Ki;Park, Deok-Bae
    • Fisheries and aquatic sciences
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    • v.15 no.1
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    • pp.21-27
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    • 2012
  • Ground seawater in the east area of the volcanic Jeju Island contains abundant minerals. We investigated the metabolic activity of electrodialyzed, desalted ground seawater (EDSW) from Jeju in both cultured cells and animals. The addition of EDSW to the culture medium (up to 20%, v/v) reduced the leakage of lactate dehydrogenase and increased MTT activity in CHO-IR cells. EDSW (10%) promoted insulin-induced glucose consumption in L6 muscle cells as well as the activities of the liver ethanol-metabolizing enzymes, alcohol dehydrogenase and aldehyde dehydrogenase. Moreover, EDSW suppressed palmitate-induced intracellular fat accumulation in human hepatoma $HepG_2$ cells. Activities of AMP-stimulated protein kinase and acetyl CoA carboxylase, enzymes that modulate fat metabolism, were altered by EDSW in $HepG_2$ cells toward the suppression of intracellular lipid accumulation. EDSW also suppressed hepatic fat accumulation induced by a high-fat diet in mice. Taken together, EDSW showed beneficial metabolic effects, including the enhancement of ethanol metabolism and insulin-induced glucose consumption, and the suppression of intrahepatic fat accumulation.

Time Course Changes in Hepatic Fat Accumulation in High Fat Diet-fed C57BL/6 Mice: Comparison Analysis to the Markers of Systemic Insulin Resistance (고지방식이 섭취 마우스에서 간 중성지방 축적의 시간에 따른 변화: 인슐린저항성 지표들과의 상관관계 분석)

  • Bae, Eun Ju
    • YAKHAK HOEJI
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    • v.56 no.6
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    • pp.364-365
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    • 2012
  • Liver is the major organ to regulate the systemic glucose homeostasis and insulin resistance. Excess energy intake leads to triglyceride accumulation in adipose tissue first and subsequent accumulation in liver, resulting in obesity and type 2 diabetes. The representative pathological animal model for obesity associated insulin resistance is a high fat diet (HFD) fed mice model. Given the essential role of liver fat accumulation in developing systemic insulin resistance in obesity, I measured the liver triglyceride contents in HFD fed mice as a function of time. As such, in this report, I show the cause and effect relationship with regard to time during a HFD feeding between a variety of factors that are related to systemic insulin resistance including glucose intolerance, plasma insulin level and inflammatory gene expression in liver and adipose tissue.

Effect of Cnidi rhizoma Boiling Extract Solution on Enzyme and Hormone of Plasma, and Liver in the Fatted Rats Induced by High Fat Dietary (천궁의 열수추출액이 고지방식이에 의한 흰쥐의 혈장 중 효소활성과 호르몬 및 간장의 지방축적에 미치는 영향)

  • 성태수;손규목
    • The Korean Journal of Food And Nutrition
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    • v.7 no.2
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    • pp.108-113
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    • 1994
  • This study was carried out to evaluate the effect of Cnidi rhizoma (CR) water extract on fat accumulation In fatted rats induced by the oral high fat administration for six weeks. To accomplish this evaluation, the serum and liver tissue have been examined for enzyme activity, cortisol and insulin level. The change of liver or tissue have been observed by the light microscope. GOT GPT and LDH activities were lower than the control group. Insulin and cortisol were higher than the control group, due to the fat accumulation. The liver of the control group observed by the tight microscope appeared to the fatty liver, but CR group showed some improvement of the fatty liver Based on the above results, it was shown that it is possible to improve fat accumulation induced by high fat dietary through using the oral administration of Cnidi rhizoma water extract.

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Dietary Supplementation of Mushroom Water Suppresses Fat Accumulation in High Fat Diet Induced-Obese Female Mice and Enhances Immune Cell Development in Non-Obese Mice

  • Bing, So Jin;Ho, Manh Tin;Sophors, Phorl;Park, Sanggyu;Yun, Young Min;Jee, Youngheun;Cho, Moonjae
    • Journal of Applied Biological Chemistry
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    • v.58 no.1
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    • pp.75-79
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    • 2015
  • Extracted mushroom water showed an ability to suppress the accumulation of body fat in female mice after feeding 5 weeks with high fat diet. Particularly, in parametrial and mesenteric adipose, it significantly reduced 44 and 47% of weight, respectively. In non-obese mice, maturated NK cell ($CD11b^{hi}CD27^{lo}$) population were increased ($70.9{\pm}3.8%$) in mushroom water fed mice compared to control ($61.4{\pm}4.3%$) and NK cell population were augmented in mushroom fed mice compared to control.