• Title/Summary/Keyword: hepatic encephalopathy

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Hepatic Encephalopathy in Captive Scimitar-Horned Oryxs (Oryx dammah) (동물원 흰오릭스에서 발생한 간성뇌증 3례)

  • Kim, Kyoo-Tae;Lee, Seung-Hun;Kwak, Dongmi
    • Journal of Veterinary Clinics
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    • v.32 no.4
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    • pp.385-388
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    • 2015
  • Three cases of hepatic encephalopathy were diagnosed in scimitar-horned oryxs housed at a zoo. Administration of amino acid and ornithine-aspartate fluid therapy via an intravenous injection decreased serum levels of ammonia and liver enzymes in cases 1 and 2. Further, additional oral ingestion of non-absorbable disaccharide lactulose to eliminate intestinal nitrogenous products enabled recovery of two oryxs. However, in case 3, the serum levels of ammonia and liver enzymes increased even after treatment, and the oryx died. Necropsy revealed cecum and colon compaction due to stiff dried feces, and this condition could have an adverse effect on increased blood ammonia levels that may have caused mortality. Overconsumption of pellets may have been the primary cause of hepatic encephalopathy. Thus, a fiber rich diet with decreased amount of pellets is needed to prevent hepatic encephalopathy, since the normal diet of scimitar-horned oryxs is rich in fiber.

3 Cases of Hepatic Encephalopathy (간성뇌증환자 3례에 대한 임상보고)

  • Ahn, Jung-Jo;Lim, Seung-Min;Cho, Hyun-Kyung;Kim, Yong-Jin;Yu, Ho-Ryong;Kim, Yun-Sik;Seol, In-Chan;Choi, Young
    • The Journal of Internal Korean Medicine
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    • v.22 no.4
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    • pp.743-747
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    • 2001
  • Hepatic encephalopathy is caused by disorders affecting the liver. The exact cause of the disorder is unknown. It occurs changes in mental state, consciousness, behavior, personality and changes in mood include forgetfulness, confusion, disorientation, delirium, dementia, decreased alertness, daytime sleepiness, decreased responsiveness, progressive stupor, coma. As 3 admission patients into oriental hospital of daejeon university include 2 cases of cerebral infarction, 1 case of liver cirrhosis, we found those are all hepatic encephalopathy. But until the diagnosis is made, we have many mistakes to find correct. Among the mistackes, specialy mixed thing is to compare hepatic encephalopathy and cerebral infarction. So, we report these cases with a brief review of related literatures.

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Clinical Study on Hepatic Encephalopathy (간성뇌병증 환자의 증례 1례)

  • Kim, Do-Gyoung;Jeong, Hyun-Yun;Lee, Jae-Wook;Shin, Yoon-Ri;Sin, Cheol-Kyung;Kim, Kyung-Min;Kim, Young-Kyun;Lee, Yong-Tae;Kwon, Jung-Nam
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.24 no.4
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    • pp.702-706
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    • 2010
  • The clinical manifestation of Hepatic encephalopathy is personality change, vacant behavior, lethargy, flapping tremor, muscle twitching, noisy, abusive, violent, coma. The purpose of this clinical study was done to report the improvement of hepatic encephalopathy after oriental medical treatment (herb-med, acupuncture, moxibustion). We applied Ukieum-ja and Sopungsungi-won to patient who had liver cirrhosis and hepatic encephalopathy. We examined the Change of CBC, LFT and Clinical Manifestation to evaluate the effectiveness of oriental medical treatment. We observed that oriental medical complex treatment decreased symtoms and improved general condition of a patient. So we report this clinical study to be helpful in treating patients of hepatic encephalopathy.

The Pallidal Index in Patients with Acute-on-Chronic Liver Disease: Is It a Predictor of Severe Hepatic Encephalopathy?

  • Lee, Dong Hyun;Lee, Hui Joong;Hahm, Myong Hun
    • Investigative Magnetic Resonance Imaging
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    • v.21 no.3
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    • pp.125-130
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    • 2017
  • Purpose: To evaluate the clinical significance of T1 high signal intensity on the globus pallidus as a predictor of severe hepatic encephalopathy in patients with acute-on-chronic liver failure (ACLF), which is a distinct syndrome characterized by multi-organ dysfunction including cerebral failure. Materials and Methods: From January 2002 to April 2014, we retrospectively reviewed the magnetic resonance imaging (MRI) findings and clinical and magnetic resonance (MR) features of 74 consecutive patients (44 men and 30 women; mean age, 59.5 years) with liver cirrhosis. The chronic liver failure-sequential organ failure assessment score was used to diagnose ACLF. The pallidal index (PI), calculated by dividing the mean signal intensity of the globus pallidus by that of the subcortical frontal white matter were compared according to ACLF. The PI was compared with the Model for End-Stage Liver Disease (MELD) score in predicting the development of ACLF. Results: Fifteen patients who were diagnosed with ACLF had higher hepatic encephalopathy grades (initial, P = 0.024; follow-up, P = 0.002), MELD scores (P < 0.001), and PI (P = 0.048). In the ACLF group, the mean PI in patients with cerebral failure was significantly higher than that in the patients without cerebral failure (1.33 vs. 1.20, P = 0.039). In patients with ACLF, the area under the curve (AUC) for PI was 0.680 (95% confidence intervals [CI], 0.52-0.85), which was significantly lower than that for the MELD score (AUC, 0.88; 95% CI, 0.77-0.99) (P = 0.04). Conclusion: The PI can be an ancillary biomarker for predicting the development of ACLF and severe hepatic encephalopathy.

Hepatoprotective effect of sodium hydrosulfide on hepatic encephalopathy in rats

  • Kwon, Kyoung Wan;Nam, Yoonjin;Choi, Won Seok;Kim, Tae Wook;Kim, Geon Min;Sohn, Uy Dong
    • The Korean Journal of Physiology and Pharmacology
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    • v.23 no.4
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    • pp.263-270
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    • 2019
  • Hydrogen sulfide is well-known to exhibit anti-inflammatory and cytoprotective activities, and also has protective effects in the liver. This study aimed to examine the protective effect of hydrogen sulfide in rats with hepatic encephalopathy, which was induced by mild bile duct ligation. In this rat model, bile ducts were mildly ligated for 26 days. Rats were treated for the final 5 days with sodium hydrosulfide (NaHS). NaHS ($25{\mu}mol/kg$), 0.5% sodium carboxymethyl cellulose, or silymarin (100 mg/kg) was administered intraperitoneally once per day for 5 consecutive days. Mild bile duct ligation caused hepatotoxicity and inflammation in rats. Intraperitoneal NaHS administration reduced levels of aspartate aminotransferase and alanine aminotransferase, which are indicators of liver disease, compared to levels in the control mild bile duct ligation group. Levels of ammonia, a major causative factor of hepatic encephalopathy, were also significantly decreased. Malondialdehyde, myeloperoxidase, catalase, and tumor necrosis factor-${\alpha}$ levels were measured to confirm antioxidative and anti-inflammatory effects. N-Methyl-D-aspartic acid (NMDA) receptors with neurotoxic activity were assessed for subunit NMDA receptor subtype 2B. Based on these data, NaHS is suggested to exhibit hepatoprotective effects and guard against neurotoxicity through antioxidant and anti-inflammatory actions.

Hepatic Encephalopathy in a Dog (개의 간성 뇌증)

  • 반현정;황철용;김종민;윤화영;윤정희;오태호;한홍율
    • Journal of Veterinary Clinics
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    • v.18 no.3
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    • pp.293-296
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    • 2001
  • Hepatic encephalophthy was diagnosed with serum chemistry, abdominal radiography and ultrasonography in a 2.6kg, 4 year-old maltese dog showing signs of hypersalivation, involutary spasm of facial muscles, ataxia, behavior abnormalities like dullness, sleep disorder, restlessness. In serum chemistry, the level of alanine transferase and aspartate trasferase was mildly elevated, ammonia was severely increased. On abdominal radio-graphs, the size of liver was mildly decreased. In ultrasonographic examination, diffuse lesion with hyperechoic change and decreased vasculature were seen in the hepatic region. But vascular abnormalities of liver were not observed. Drug and dietary therapy were undertaken and severities of clinical sign were alleviated.

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Case Report of Liver Cirrhosis with Diabetes Mellitus and Hepatic Encephalopathy (당뇨병과 간성뇌증이 동반된 간경변증 1례)

  • Na, Ran-Hee;Lee, Jung-Wook;Han, Deok-Jin;Bang, Chang-Ho;Jang, Seok-Oh;Choi, Ji-Hye;Kim, Kang-San
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.23 no.4
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    • pp.919-924
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    • 2009
  • The liver is one of the principal organs involved in glucose metabolism. Diabetes mellitus(DM) commonly develops in patients with liver cirrhosis as a result of hepatocyte dysfunction. Hepatic encephalopathy(HE) is a major neuropsychiatric complication of liver cirrhosis. HE develops frequently in advanced stage of liver cirrhosis due to portal hypertension. We experienced a case of liver cirrhosis with DM and HE in 67 years old male patient. The patient's symptoms were lethargy, general malaise, asterixis, dizziness, and heavy headedness. Hwangryunjihwang-tang, Saengkankunbi-tang, Injinchija-tang and Injinho-tang were prescribed to the patient. Finally, the symptoms had been improved, however significant change was not observed from serum ammonia, fasting blood sugar and postparandial blood sugar. So we hope that this case report will be helpful in treating patient of liver cirrhosis.

The High Expressed Serum Soluble Neural Cell Adhesion Molecule, a High Risk Factor Indicating Hepatic Encephalopathy in Hepatocelular Carcinoma Patients

  • Liu, Tian-Hua;Guo, Kun;Liu, Ri-Qiang;Zhang, Shu;Huang, Zhuo-Hui;Liu, Yin-Kun
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.8
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    • pp.3131-3135
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    • 2015
  • Objective: To investigate whether the expression of serum soluble neural cell adhesion molecule (sNCAM) is associated with hepatic encephalopathy (HE) in hepatocelular carcinoma (HCC) patients. Materials and Methods: The Oncomine Cancer Microarray database was used to determine the clinical relevance of NCAM expression in different kinds of human cancers. Sera from 75 HCC cases enrolled in this study were assessed for expression of sNCAM by enzyme linked immunosorbent assay (ELISA). Results: Dependent on the Oncomine Cancer Microarray database analysis, NCAM was down regulated in 10 different kinds of cancer, like bladder cancer, brain and central nervous system cancer, while up-regulated in lung cancer, uterine corpus leiomyoma and sarcoma, compared to normal groups. Puzzlingly, NCAM expression demonstrated no significant difference between normal and HCC groups. However, we found by quantitative ELISA that the level of sNCAM in sera from HCC patients with HE ($347.4{\pm}151.9ng/ml$) was significantly more up-regulated than that in HCC patients without HE ($260.3{\pm}104.2ng/ml$), the p-value being 0.008. sNCAM may be an important risk factor of HE in HCC patients, the correlation coefficients was 0.278 (P<0.05) on rank correlation analysis. Conclusions: This study highlights that up-regulated level of serum sNCAM is associated with HE in HCC patients and suggests that the high expression can be used as an indicator.

Diagnosis and Management of Acute Liver Failure in Children (소아에서 급성 간부전의 진단과 치료)

  • Shim, Jung Ok
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.11 no.sup2
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    • pp.50-58
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    • 2008
  • Acute liver failure is a devastating disease in children. Most cases of acute liver failure in children are indeterminate; however, metabolic liver disease is one of the main causes in the pediatric age group. Though a major symptom of acute liver failure is hepatic encephalopathy, this is very difficult to diagnose, particularly in younger children. Liver transplantation has improved the chances of survival dramatically; however, it is not known which patients are ideal candidates for liver transplantation. Because patients may deteriorate rapidly, arranging care in a center with expertise will secure the best possible outcomes.

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Electroencephalogram Power Spectra in Thioacetamide-induced Hepatic Encephalopathy (Thioacetamide 유발 간성뇌장애에서 뇌파 Power Spectra)

  • Lee, Chi-Hui;Choi, Won-Jin;Park, Jung-Sook;Lee, Hyang-Yi;Ha, Jeoung-Hee;Lee, Maan-Gee
    • The Korean Journal of Pharmacology
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    • v.32 no.3
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    • pp.293-300
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    • 1996
  • During the development of hepatic encephalopathy after thioacetamide (TAA) injection to rat, EEG was recorded at two different states: without or with tactile stimulation of tail at regular intervals. Calculations based on the spectral and band analysis were used. The changes in the power spectra and bands were examined in 3 different behavioral stages: normal, mild ataxia and severe ataxia. In normal rats, the stimulation produced the increase in the power of the theta $(3.5{\sim}8\;Hz)$ and the gamma $(30{\sim}50\;Hz)$ bands. These changes could not be produced in rats with the mild and severe ataxia. The changes in the power of the theta band occurred earlier than those of the beta3 and the gamma bands in the stimulated state. Gradual decreases in the spectral power of the beta3 $(21{\sim}30\;Hz)$ and the gamma bands were correlated with the progress of the stages from normal condition to mild to severe ataxia in both unstimulated and stimulated states. The results indicate that the spectral and band analysis used in this study can quantify the severity of the neurological malfunction during HE.

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