• Title, Summary, Keyword: histidine-enriched diet

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Suppressed Fat Accumulation in Rats Fed a Histidine-Enriched Diet

  • Endo, Michiko;Kasaoka, Seiichi;Takizawa, Miki;Goto, Kiyoko;Nakajima, Shigeru;Moon, Soo-Kyung;Kim, In-Soo;Jeong, Bo-Young;Nakamura, Soichiro
    • Preventive Nutrition and Food Science
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    • v.15 no.1
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    • pp.1-6
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    • 2010
  • The effect on body fat accumulation on male Wistar rats undergoing continuous feeding with a histidine-enriched diet was investigated. Five-week-age rats were assigned to two groups and were fed either the control diet (purified diet AIN-$76^{TM}$) or the histidine-enriched diet containing 3% histidine for 28 days. It was observed that both adipose tissue masses in retroperitoneal and epididymal areas of rats fed histidine-enriched diet significantly decreased (p<0.05) compared to those of control rats, while there was no significant difference in the food efficiency ratio between them. The blood levels of histidine derivatives of 3-methylhistidine and carnosine were significantly (p<0.05) increased in the rats fed a histidine-enriched diet, whereas there were no significant different between the histidine-enriched diet and control groups in the general amino acid distribution. Our results demonstrate that a histidine-enriched diet suppresses body fat accumulation in rats.