• Title, Summary, Keyword: hydrated liquid crystalline vesicle

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Effects of Edge Activator on the Droplet Size and Skin Permeation of Hydrated Liquid Crystalline Vesicles (Edge Activator가 수화 액정형 베시클의 입자크기와 피부 침투에 미치는 영향)

  • Lee, Seo Young;Lim, Yoon Mi;Jin, Byung Suk
    • Applied Chemistry for Engineering
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    • v.28 no.6
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    • pp.679-684
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    • 2017
  • Hydrated liquid crystalline vesicles incorporating a edge activator, which confers flexibility to the vesicle membranes, were prepared and niacinamide was encapsulated in them. The formation of liquid crystalline phases and their thermal phase transitions were investigated by polarized optical microscopy and differential scanning calorimetry (DSC), respectively. Droplet sizes of the vesicles were reduced to several tens of nanometers by incorporating edge activators, such as sodium deoxycholate, lysolecithin, or polysorbate 80. The amount of niacinamide permeated into a pig skin increased greatly using the hydrated liquid crystalline vesicles compared to the case where niacinamide was applied in an aqueous solution state. The vesicles incorporating 10% sodium deoxycholate increased the amount of niacinamide permeated nearly four times. These results suggest that edge activators are effective in improving the skin permeability of vesicles.

Characteristics of L-Ascorbic Acid Encapsulated BGsome and its Stabilization Effect (L-ascorbic acid가 포집된 BGsome의 특성 및 안정화 효과)

  • Hwang, Sue-Yun;Jin, Byung-Suk
    • Journal of the Korean Applied Science and Technology
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    • v.28 no.3
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    • pp.313-320
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    • 2011
  • Encapsulation of L-ascorbic acid(AA) into BGsome was attempted to improve its stability. BGsome is a bio-compatible vesicular system prepared by dispersion of hydrated liquid crystalline phase formed through hydration of 1,3-butylene glycol(BG)-dissolved lecithin with an aqueous solution containing hydrophilic component. The characteristics of AA encapsulated BGsome, such as droplet size, surface charge, and solution appearance, was investigated. The concentration of AA solution had considerable effect on droplet size and surface charge of BGsome. Several tens nanometer droplet made by sonication treatment did not showed any change of size with storage time. Stability of AA was improved by encapsulation into BGsome, which was verified through DPPH test and HPLC assay.

A Study on the Factors Affecting Entrapment Efficiency and Particle Size of Ethosomes (Ethosomes의 포집효율과 입자크기에 영향을 주는 인자에 관한 연구)

  • Jin, Byung Suk;Lee, Sang Mook;Lee, Kwang Hee
    • Applied Chemistry for Engineering
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    • v.17 no.2
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    • pp.138-143
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    • 2006
  • Ethosome is a liquid crystalline vesicle prepared by hydration of ethanol-dissolved lecithin with a solution containing hydrophilic components. Investigation of factors affecting the entrapment efficiency and particle size of ethosomes was carried out, because the high entrapment efficiency and small particle size are prerequisite in developing ethosomes as a drug delivery system. The variations of properties of ethosomes with constituent composition and preparation method were examined using a calcein as a hydrophilic marker. It was observed that the amount of ethanol and calcein solution, phosphatidyl choline content in lecithin, preparation temperature, stirring rate, and PBS addition method had a considerable effect on the properties of ethosome. Sonication treatment resulted in the reduction of entrapment efficiency of ethosome, which was due to the release of entrapped components in the vesicles by strong sonication vibration.