• Title, Summary, Keyword: hypoglycemic

Search Result 414, Processing Time 0.049 seconds

Study on Hypoglycemic Effect of Polygonatum officinale All. Extracts and Its Interaction with Oral Hypoglycemic Agents (편황정(片黃精)의 혈당강하작용(血糖降下作用) 및 경구혈당강하제(經口血糖降下劑)와의 상호작용(相互作用)에 관(關)한 연구(硏究))

  • Lee, Wan-Ha;Jee, Ung-Kil;Ahn, Tae-Hong
    • Journal of Pharmaceutical Investigation
    • /
    • v.12 no.1
    • /
    • pp.12-22
    • /
    • 1982
  • The experimental study have showed that the Polygonatum officinale All. contains diosgenin and ${\beta}-sitosterol$ as active components. Even though many experimental studies were reported, still there are many unknown actions of components from the plant. The purpose of this study was to elucidate the mechanism of hypoglycemic action of ether extract of Polygonatum officinale. The hypoglycemic effect of the ether extract was tested in hyperglycemic rats induced experimentally, The effect on plasma free fatty acid and the acute toxicity were also examined by using mouse. The hypoglycemic effect of the ether extract was compared with other oral hypoglycemic agents such as chlorpropamide and buformin. The ether extract of Polyonatum officinale showed a marked hypoglycemic effect by 1 hour after oral administration in hyperglycemic rats and rabbits but the ethanol extract did not exhibit the hypoglycemic effect. The hypoglycemic effect of the ether extract was potentiated by chlorpropamide while buformin was weak.

  • PDF

Hypoglycemic Effects of Eryngium Creticum

  • Jaghabir, Madi
    • Archives of Pharmacal Research
    • /
    • v.14 no.4
    • /
    • pp.295-297
    • /
    • 1991
  • E. creticum has been used in folk medicine in Jordan as a remedy for scorpion stings in the rural areas and as a hypoglycemic agent. The hypoglycemic activity of an aquous decoction of plant arial parts of E. creticum was tested in normoglycemic and streptozocin-hyperglycemic rats. Results indicate that those extract caused significant reductions in blood glucose concentration when given orally.

  • PDF

Peptide Profiling and Selection of Specific-Expressed Peptides in Hypoglycemic Sorghum Seed using SELDI-TOF MS (SELDI-TOF MS를 활용한 혈당강하 수수 종자의 펩타이드 프로파일링 및 특이 발현 펩타이드 선발)

  • Park, Sei Joon;Hwang, Su Min;Park, Jun Young;Ko, Jee-Yeon;Kim, Tae Wan
    • KOREAN JOURNAL OF CROP SCIENCE
    • /
    • v.59 no.3
    • /
    • pp.252-262
    • /
    • 2014
  • Sorghum seed is traditionally used as secondary food sources in addition to rice in Korea. While the hypoglycemia regulating phytochemicals have been found in sorghum seed, peptides related with hypoglycemia never been studied before. To obtain the peptide characteristics and the specifically high-expressed peptides in hypoglycemic sorghum seed, peptide profiles of seven hypoglycemic and five non-hypoglycemic sorghum lines bred in RDA were determined using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS). The twelve sorghum lines exhibited 104 peptides on CM10 protein chip array (weak cation exchange) and 95 peptides on Q10 (weak cation exchange) in the molecular mass range from 2,000 to 20,000 Da. Heat map via supervised hierarchical clustering of the significantly different peptides (p < 0.01) in peak intensity among the 12 lines effectively revealed the specifically upregulated peptides in each line and distinguished between 7 hypoglycemic and 5 non-hypoglycemic lines. Through the comparison with hypoglycemic and non-hypoglycemic lines, 10 peptides including 2231.6, 2845.4, 2907.9, 3063.5, 3132.6, 3520.8, 4078.8, 5066.2, 5296.5, 5375.5 Da were specifically high-expressed in hypoglycemic lines at p < 0.00001. This study characterized seed peptides of 12 sorghums and found ten peptides highly expressed for hypoglycemic sorghum lines, which could be used as peptide biomarkers for identification of hypoglycemic sorghum.

Hypoglycemic Activities of a Mangrove Plant Rhizophora apiculata Blume

  • Sur, Tapas Kumar;Seal, Tapan;Pandit, Srikanta;Bhattacharyya, Dipankar
    • Natural Product Sciences
    • /
    • v.10 no.1
    • /
    • pp.11-15
    • /
    • 2004
  • The leaves of Rhizophora apiculata, a plant belonging to the family Rhizophoraceae were collected from the mangrove forest of Sunderbans, West Bengal, India. Alcoholic extract of the leaves of this plant was prepared and hypoglycemic/anti-hyperglycemic activity was studied in fed rats, glucose loaded rats and streptozotocin induced diabetic rats. The results of this study reveal that this plant extract has potential hypoglycemic action.

Hypoglycemic and Hypolipemic Effects of Ixeris dentata in Diabetic Rats

  • Choi, Jae-Sue;Young, Han-Suk;Kim, Byung-Woo
    • Archives of Pharmacal Research
    • /
    • v.13 no.3
    • /
    • pp.269-273
    • /
    • 1990
  • Blood glucose and total lipid levels in rats with streptozotocin-induced diabetes were determined after intraperitoneal administration of methanolic extract of Ixeris dentat whole plants and its main component, cynaroside (=luteolin 7-O--$\beta$-D-glucoside). From the data obtained, it was concluded that intraperitoneal administration of the methanolic extract produced a significant hypoglycemic effect. Total blood lipids were also decreased. Cynaroside in the streptozotocin-diabetic rats failed to exhibit hypoglycemic effect but a significant hypolipemic activity was observed. Thus, it is suggested that this methanolic extract may contain one or more hypoglycemic and hypolipemic principles including the main flavone glucoside, cynaroside, which can significantly reduce the levels triglyceride and total cholesterol in streptozotocin-diabetic rats.

  • PDF

A Case of Severe Hypoglycemic Encephalopathy with Extensive Brain Lesions in Non-diabetics and Alcoholism (당뇨병이 없는 알코올중독 환자에서 광범위한 뇌병변을 보인 저혈당성 뇌병증 1예)

  • Bin, Chang-Hun;Park, Min-Su;Lee, Se-Jin
    • Yeungnam University Journal of Medicine
    • /
    • v.27 no.1
    • /
    • pp.37-41
    • /
    • 2010
  • Hypoglycemic encephalopathy is a rare problem among diabetic patients who are receiving treatment with insulin or other glucose-lowering drugs. The MRIs of patients with hypoglycemic encephalopathy commonly show scattered lesions in the cerebral cortex, hippocampus and basal ganglia, but lesions in the cerebellum or brain stem are extremely rare. A 44-year-old alcoholic woman without diabetes was admitted with a semicomatose mentality and seizure with severe hypoglycemic encephalopathy with extensive brain lesions seen on MRI at the middle cerebellar peduncle and midbrain, as well as in the other brain areas.

  • PDF

Hyperperfusion in DWI Abnormality in a Patient with Acute Symptomatic Hypoglycemic Encephalopathy

  • Park, Ji Kang
    • Investigative Magnetic Resonance Imaging
    • /
    • v.21 no.2
    • /
    • pp.106-108
    • /
    • 2017
  • The perfusion change in acute symptomatic hypoglycemic encephalopathy (ASHE) is not well known. We present the perfusion-weighted imaging of a patient with ASHE. The area of diffusion-weighted imaging abnormalities and adjacent normal-appearing white matter showed increased cerebral blood volume and flow, and shortening of time-to-peak.

Galactolipids from Mori Folium and their Hypoglycemic Effect (혈당강하효과를 나타내는 상엽의 당지질 성분)

  • Kim, Chul-Young;Kang, Si-Hyun;Jeong, Gi-Wha;Cheong, Chun-Sik;Kim, Bak-Kwang;Huh, Hoon
    • Korean Journal of Pharmacognosy
    • /
    • v.31 no.1
    • /
    • pp.95-100
    • /
    • 2000
  • In order to find out hypoglycemic constituents from natural resources, Korean medicinal plants being used for the treatments of diabetes mellitus were tested with streptozotocin-induced diabetic rats. From the above screening, the $CH_2Cl_2$ fraction of 80% methanol extracts of Morus alba leaves showed hypoglycemic activity. The $CH_2Cl_2$fraction was chromatographed on silica gel, resulting in 9 subfractions, and tested hypoglycemic activity. The subfraction which had a strong hypoglycemic activity was rechromatographed and two galactolipids (compounds 1 and 2) were isolated along with a triterpene (compound 3) from other fractions. On the basis of spectroscopic data, acid hydrolysis, alkaline hydrolysis and enzyme hydrolysis results, compounds 1, 2 and 3 were identified as $1-O-(9Z,12Z,15Z-octatrienoyl)-2-O-(9Z,12Z,15Z-octatrienoyl)-3-O-{\beta}-D-galactopyranosyl$ glycerol, $2(R)-1-O-octadecanoyl-2-O-(9Z,12Z,15Z-octatrienoyl)-3-O-{\beta}-D-galactopyranosyl$ glycerol, and $3{\beta}-hydroxylup-20(29)-ene$ acetate, respectively. Compound 2 (1mg/kg p.o.) has approximately 16% hypoglycemic activity in streptozotocin-induced diabetic rats.

  • PDF

Hypoglycemic Action of the Fat Soluble Fraction of Panax Ginseng C.A. Meyer in Streptozotocin Induced Diabetic Rats (Streptozotocin 유발 당뇨병 쥐에서의 인삼 지용성분획의 혈당 강하작용)

  • 주충노;김선진
    • Journal of Ginseng Research
    • /
    • v.17 no.2
    • /
    • pp.101-108
    • /
    • 1993
  • This study was made to understand a hypoglycemic action of the fat soluble fraction of Panax ginseng C.A. Meyer in streptozotocin induced diabetic rats by determining the activities of several enzymes related to carbohydrate and lipid metabolism as well as several blood component levels such as glucose and ketone bodies, and non-esterified fatty acids. Albino rats (Sprague Dawley, 170-200g, 3) were injected once with 70mg streptozotocinhg body weight intraperitoneally and fed with ordinary diet for 7 days, and then the fat soluble fraction (5 mg~20 mg/day/rat) was injected intraperitoneally once a day for three days to rats having high blood glucose level over 340 mg/100ml. After a final injection of the fat soluble fraction, rats u.ere starved for 16 hours followed by the analysis of blood serum and liver enzymes. It was found that increased levels of glucose, ketone bodies and free fatty acids in streptozotocin induced rats were decreased appreciably by administration of the fat soluble fraction. However, the amount of administered fat soluble fraction did not show any significantly different hypoglycemic action. Decreased activities of glucokinase, phosphofructokinase, pyruvate kinase, 6-phosphogluconate dehydrogenase and acetyl CoA carboxylase of the liver of streptozotocin induced diabetic rats were greatly modified suggesting that a hypoglycemic action of the fat soluble fraction was also appreciable as ginseng saponin fraction. We also compared a hypoglycemic action of the fat soluble fraction prepared from American ginseng and Chinese ginseng with that of Korean pain ginseng. 핀o significant difference of the hypoglycemic activity was observed between the above ginseng fat soluble fractions, suggesting that a study of the fat soluble fraction might be one of the most interesting subjects relating to diabetic hyperglycemia in the near future.

  • PDF