• Title, Summary, Keyword: immunomodulator

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Coumarins and Chromones from Angelica genuflexa

  • An, Ren-Bo;Park, Bo-Young;Kim, Jung-Hee;Kwon, Ok-Kyoung;Lee, Joong-Ku;Min, Byung-Sun;Ahn, Kyung-Seop;Oh, Sei-Ryang;Lee, Hyeong-Kyu
    • Natural Product Sciences
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    • v.11 no.2
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    • pp.79-84
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    • 2005
  • Thirteen compounds were isolated from the roots of Angelica genuflexa through repeated silica gel column chromatography. Nine coumarins, isoimperatorin (1), osthol (2), demethylsuberosin (3), oxypeucedanin (4), heraclenin (5), pabulenol (7), umbelliferone (8), oxypeucedanin hydrate (9) and marmesinin (11), and four chromones, hamaudol (6), cimifugin (10), sec-O-glucosylhamaudol (12) and prim-O-glucosylcimifugin (13), were identified by physicochemical and spectroscopic analysis. Among these, compounds 3, 5, 6, 8, 12, and 13 were isolated for the first time from the roots of Angelica genuflexa. These coumarins and chromones were examined for their anticomplement activity. Demethylsuberosin (3) showed a weak anticomplement activity with an $IC_{50}$ value of $390\;{\mu}M$.

Anti-Complement Activity of Constituents from the Stem-Bark of Juglans madshurica

  • Min, Byung-Sun;Kim, Jung-Hee;An, Ren-Bo;Lee, Joong-Ku;Kim, Tae-Jin;Kim, Young-Ho;Joung, Hyouk;Lee, Hyeong-Kyu
    • Proceedings of the PSK Conference
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    • pp.260.2-261
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    • 2003
  • Four known flavonoids and two galloyl glucoses isolated from the stem-bark of Juglans mandshurica (Juglandaceae), namely taxifolin (1), afzelin (2), quercitrin (3), myricitrin (4), 1,2,6-trigalloylglucose (5), and 1,2,3,6-tetragalloylglucose (6), were evaluated for their anti-complement activity against complement system. (omitted)

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Anti-complement Activity of Flavonoids from Litsea japonica

  • Lee, Sun-Young;Min , Byung-Sun;Kim, Jung-Hee;Moon, Hyung-In;Lee, Joong-Ku;Kim, Tae-Jin;Kim, Young-Ho;Lee, Hyeong-Kyu
    • Proceedings of the PSK Conference
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    • pp.372.1-372
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    • 2002
  • AIzelin (1) and quercitrin (2) isolated from the EtOAc-soluble fraction of the leaves of Litsea japonica Jussieu (Lauraceae) showed inhibitory activity against classical pathway complement system with 50% inhibitory concentration ($IC_{50}$/) values of 112.2 and 198.2 $\mu\textrm{g}$/$m\ell$. respectively. For the structure-activity relationship of flavonoids on anti-complement system. myricitrin (3) from JUQ/ans mandshurica Maximowicz (Juglandaceae) also tested anti-complement activity. while this was devoid of any significant activity. (omitted)

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Neuroprotective and Free Radical Scavenging Activities of Phenolic Compounds from Hovenia dulcis

  • Li, Gao;Min, Byung-Sun;Zheng, Chang-Ji;Lee, Joong-Ku;Oh, Sei-Ryang;Ahn, Kyung-Seop;Lee, Hyeong-Kyu
    • Archives of Pharmacal Research
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    • v.28 no.7
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    • pp.804-809
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    • 2005
  • The EtOAc-soluble fraction from a methanolic extract of Hovenia dulcis Thunb. exhibited neuroprotective activity against glutamate-induced neurotoxicity in mouse hippocampal HT22 cells. The neuroprotective activity-guided isolation resulted in 8 phenolic compounds (1-8), such as vanillic acid (1), ferulic acid (2), 3,5-dihydroxystilbene (3), (+)-aromadendrin (4), methyl vanillate (5), (-)-catechin (6), 2,3,4-trihydrobenzoic acid (7), and (+)-afzelechin (8). Among these, compounds 6 and 8 had a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells. Furthermore, compound 6 had a DPPH free radical scavenging effect with an $IC_{50}$ value of $57.7{\mu}M$, and a superoxide anion radical scavenging effect with an $IC_{50}$ value of $8.0{\mu}M$. Both compounds 6 and 8 had ABTS cation radical scavenging effects with $IC_{50}$ values of $7.8{\mu}M\;and\;23.7${\mu}M$, respectively. These results suggest that compounds 6 and 8 could be neuroprotectants owing to their free radical scavenging activities.

Prostane-type Triterpenes from Alismatis Rhizoma and Their Anti-complement Activity

  • Lee, Sang-Myung;Kim, Jung-Hee;An, Ren-Bo;Na, Min-Kyun;Min, Byung-Sun;Bae, Ki-Hwan;Lee, Hyeong-Kyu
    • Proceedings of the PSK Conference
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    • pp.373.3-374
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    • 2002
  • Alismatis Rhizoma is originated from the rhizome of Alisma plantago-aquatica L. var. orientale Samuelson or A. canaliculatum A. Br. et Bouche (Alismataceae). Prostane-type triterpenes, guaiane-type sesquiterpenes, and kaurane-type diterpenes have been reported as the main canstituents from these plants. Four prostane-type triterpenes. alisol B 23-acetate (1). alisol C 23-acetate (2), alisol B (3). and alisol A 24-actate (4). were isolated from the EtOAc-soluble fraction of this dried rhizome. (omitted)

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