• Title, Summary, Keyword: in-vivo 영상

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Comparison of in Vivo, in Vitro 3T MR Spectroscopy and Proton NMR Spectroscopy for the Fluid from Cystic Tumor: Preliminary Study (낭성 종양의 체액에 대한 생체내, 생체외 3T 양성자 자기공명분 광법과 양성자 핵자기공명기법의 비교: Preliminary Study)

  • Lee, Hui-Joong;Kim, Jong-Yeol;Chang, Yong-Min
    • Investigative Magnetic Resonance Imaging
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    • v.12 no.2
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    • pp.107-114
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    • 2008
  • Purpose : The aim of this study is to determine possibility of application of in vivo proton ($^1H$) magnetic resonance spectroscopy (MRS) in distinguishing cystic mass arising around pancreas by comparison of in vivo MRS, in vitro MRS using 3T MR machine, based on nuclear magnetic resonance (NMR). Materials and Methods : We obtained spectra of in vivo MRS, in vitro MRS and NMR from abdominal mass arising around pancreas (mucinous cystic neoplasm=5, intraductal papillary mucin producing tumor=5, pseudocyst=1, and lymphangioma=1). We estimated existence of peak of in vivo MRS, and in vitro MRS concordant to that of NMR. We also evaluated differential peak for predicting specific disease. Results : Correlation of presence of peak with NMR showed showed sensitivity of 29.6%, specificity of 82.6% and accuracy of 67.7% on in vivo MRS (p = 0.096, McNemar test), sensitivity of 57.1% and specificity of 92.6% and accuracy of 82.3% on in vitro MRS (p = 0.362, McNemar test). The spectra of NMR for IPMT showed more frequent peaks at 3.5-4.0 ppm (p=0.026). Conclusion : Although chemical analysis, using NMR could be regarded as possible tool to differentiate cystic masses, in vivo and in vitro MRS need further technical evolution for clinical application.

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In vivo visualization of liquid-feeding phenomena of a butterfly (나비 펌프의 구조와 동적 거동의 in vivo 가시화)

  • Lee, Seung-Chul;Kim, Bo-Heum;Lee, Sang-Joon
    • Journal of the Korean Society of Visualization
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    • v.9 no.4
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    • pp.69-73
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    • 2011
  • Butterflies have been known to suck viscous liquids through a long, cylindrical proboscis using the large pressure difference formulated by the cyclic expansion and contraction of a muscular pump located inside their head. However, there are few studies on the liquid-feeding phenomena in a live butterfly, because it is hard to observe the internal morphological structures under in vivo condition. In this study, the dynamic motion of the pump system in a butterfly was in vivo visualized using synchrotron X-ray micro-imaging technique to analyze the liquid-feeding mechanism. The period of the liquid-feeding process is about 0.3sec. The expansion stage is about two times larger than the contraction stage in one cycle. The cyclic variation of pump volume generate large negative suction pressure and the pressure difference inside the long proboscis of a butterfly is estimated to be larger than 1atm.

Pulse Sequence based MR Images for Compressed Sensing Algorithm Applications (펄스열을 이용한 MR 영상의 Compressed Sensing 알고리즘 적용)

  • Gho, Sung-Mi;Choi, Na-Rae;Kim, Dong-Hyun
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.46 no.5
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    • pp.1-7
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    • 2009
  • In recent years, compressed sensing (CS) algorithm has been studied in various research areas including medical imaging. To use the CS algorithm, the signal that is to be reconstructed needs to have the property of sparsity But, most medical images generally don't have this property. One method to overcome this problem is by using sparsifying transform. However, MR imaging, compared to other medical imaging modality, has the unique property that by using appropriate image acquisition pulse sequences, the image contrast can be modified. In this paper, we propose the possibility of applying the CS algorithm with non-sparsifying transform to the pulse sequence modified MR images and improve the reconstruction performance of the CS algorithm by using an appropriate sparsifying transform. We verified the proposed contents by computer simulation using Shepp-Logan phantom and in vivo data.

Quantitation of In-Vivo Physiological Function using Nuclear Medicine Imaging and Tracer Kinetic Analysis Methods (핵의학 영상과 추적자 동력학 분석법을 이용한 생체기능 정량화)

  • Kim, Su-Jin;Kim, Kyeong-Min;Lee, Jae-Sung
    • Nuclear Medicine and Molecular Imaging
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    • v.42 no.2
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    • pp.145-152
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    • 2008
  • Nuclear medicine imaging has an unique advantage of absolute quantitation of radioactivity concentration in body. Tracer kinetic analysis has been known as an useful investigation methods in quantitative study of in-vivo physiological function. The use of nuclear medicine imaging and kinetic analysis together can provide more useful and powerful intuition in understanding biochemical and molecular phenomena in body. There have been many development and improvement in kinetic analysis methodologies, but the conventional basic concept of kinetic analysis is still essential and required for further advanced study using new radiopharmaceuticals and hybrid molecular imaging techniques. In this paper, the basic theory of kinetic analysis and imaging techniques for suppressing noise were summarized.

Nuclear Medicine Imaging Instrumentations for Molecular Imaging (분자영상 획득을 위한 핵의학 영상기기)

  • Chung, Yong-Hyun;Song, Tae-Yong;Choi, Yong
    • The Korean Journal of Nuclear Medicine
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    • v.38 no.2
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    • pp.131-139
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    • 2004
  • Small animal models are extensively utilized in the study of biomedical sciences. Current animal experiments and analysis are largely restricted to in vitro measurements and need to sacrifice animals to perform tissue or molecular analysis. This prevents researchers from observing in vivo the natural evolution of the process under study. Imaging techniques can provide repeatedly in vivo anatomic and molecular information noninvasively. Small animal imaging systems have been developed to assess biological process in experimental animals and increasingly employed in the field of molecular imaging studies. This review outlines the current developments in nuclear medicine imaging instrumentations including fused multi-modality imaging systems for small animal imaging.

An Experimental Study of the Synthetic Sinc Wave in Ultrasonic Imaging (초음파 의료 영상에서 합성 Sinc 음장 집속방법의 실험적 고찰)

  • 이광주;정목근
    • Journal of Biomedical Engineering Research
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    • v.23 no.3
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    • pp.243-251
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    • 2002
  • Synthetic zinc wave employs Pulsed plane wave as transmit beam with linear time delay curve. The received echoes in different transmit directions at different transmit times are superposed at imaging Points with Proper time delay compensation using synthetic focusing scheme. This scheme. which uses full aperture in transmit, obtains a high SNR image, and also features high lateral resolution by using two way dynamic focusing at all imaging depths. In this Paper, we consider the Problems in realization of synthetic zinc wave. Also. we have applied the scheme to obtain phantom and in-vivo images using a linear array of 5 MHz. In phantom test. experimental images show high resolution over a more extended imaging depth than conventional fixed Point transmit and receive dynamic focusing schemes In-vivo images show that the resolution could not overcome conventional focusing systems because of motion blurring and(or) aberration of tissue. but the frame rate tan be increased by a factor of more than 5 compared to conventional focusing schemes. with competitive resolution at all imaging depths .

Synchrotron Radiation Imaging of Tissues Using Phase Contrast Technique (방사광 위상차 현미경을 이용한 생체조직의 미세구조 영상)

  • Kang, Bo-Sun;Lee, Dong-Yeol;Kim, Ki-Hong
    • Journal of the Korean Society of Radiology
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    • v.2 no.2
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    • pp.23-30
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    • 2008
  • X-ray microscopy with synchrotron radiation(SR) might be a useful tool for novel x-ray imaging in the clinical and laboratory settings. Microscopically, it enables us to observe detailed structure of animal organs samples with a great magnification power and an excellent resolution. The phase contrast mechanisms in image by X-ray are described. The phase-contrast X-ray imaging with SR from in-vivo and in-vitro mouse tail, rat nerve and rat lung were obtained with an 8 KeV monochromatic beam. The visual image was magnified using 10x microscope objective lens and captured using an digital CCD camera. The results showed more structural details and high resolution images with SR imaging system than conventional X-ray radiography system. The SR imaging system may have a potential for imaging in biological researches, material applications and clinical radiography.

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Variations of imaging depth and chloroplast emission spectrum of Arabidopsis thaliana with excitation wavelength in two-photon microscopy (이광자현미경 여기 광 파장에 따른 Arabidopsis thaliana 촬영 깊이 및 엽록체 형광 스펙트럼의 변화)

  • Joo, Yongjoon;Son, Si Hyung;Kim, Ki Hean
    • Journal of the Korean Society of Visualization
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    • v.12 no.3
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    • pp.9-14
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    • 2014
  • Two-photon microscopy (TPM) has been used in plant research as a high-resolution high-depth 3D imaging modality. However, TPM is known to induce photo-damage to the plant in case of long time exposure, and optimal excitation wavelength for plant imaging has not been investigated. Longer excitation wavelength may be appropriate for in vivo two-photon imaging of Arabidopsis thaliana leaves, and effects of longer excitation wavelength were investigated in terms of imaging depth, emission spectrum. Changes of emission spectrum as a function of exposure time at longer excitation wavelength were measured for in vivo longitudinal imaging. Imaging depth was not changed much probably because photon scattering at the cell wall was a limiting factor. Chloroplast emission spectrum showed its intensity peak shift by 20 nm with transition of excitation wavelength from 849 nm or below to 850 nm or higher. Emission spectrum showed different change patterns with excitation wavelengths in longitudinal imaging. Longer excitation wavelengths appeared to interact with chloroplasts differently in comparison with 780 nm excitation wavelength, and may be good for in vivo imaging.

3T MR Imaging에 적합한 RF Surface Coil의 개발: 피부 미세구조에 대한 예비 연구

  • 윤성익;이정우;최보영;이형구;서태석
    • Proceedings of the KSMRM Conference
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    • pp.73-73
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    • 2003
  • 목적: 피부조직과 같은 미세 인체구조 연구를 위해 고해상도 3T MRI 시스템에 적합한 고분해능의 RF surface coil을 개발하고 있다. In vivo 연구를 위한 여러 parameter를 최적화하여 기능영상에도 부합된다. 비침습적인 In vivo 검사에 의한 세포수준의 극 미세구조의 연구가 가능해짐으로써 과거 시행하던 침습적인 생검없이 각종질환의 진단적 접근이 병리학적 수준으로 향상되어 질병의 정확한 진단이 가능해지게 될 것이다.

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Acquirement of in vivo epidermal cross-sectional image by using swept source optical coherence tomography (SS-OCT 방식을 이용한 생체의 표피단면 영상 획득)

  • Kim, Hoon-Sup;Lim, Hae-Jin;Eom, Jin-Seob
    • Journal of Industrial Technology
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    • v.28 no.A
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    • pp.163-166
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    • 2008
  • In this paper, the swept source optical coherence tomography system has realized using a free-space interferometer based on a beam splitter. Personal computer has completed the control for tunable wavelength laser digitally and the B-scan motor as well. From each experiment for an onion and a salmon egg, we confirmed that the in vivo epidermal cross-sectional images for them can be obtained appropriately.

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