• Title, Summary, Keyword: ion-selective electrode

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Determination of Mefenamic acid with ISEs Using Ternary Complex of Metal -phenanthroline -mefenamate as Ion-exchanger (이온교환체로서 금속 -페난드롤린 -메페남산 3원 작물을 이용한 메페남산의 정량)

  • 허문회;김대병;남수자;문현숙;이미나;정문모;안문규
    • YAKHAK HOEJI
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    • v.45 no.1
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    • pp.29-33
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    • 2001
  • A method for the determination of anionic drug, mefenamate with ion-selective electrode using Fe(II)-1,10-phenanthroline chelate as a counter ion was developed. Benzyl nitrophenyl ether (BNPE) plasticized membrane was more selective and sensitive than the other tested membranes. This membrane electrode exhibits a linear response for 10$^{-2}$ M~5 $\times$ 10$^{-5}$ M of mefenamic acid with a slope of -61.4 mV/dec. in borate buffer solutions (pH 9.0). Potentiometric selectivity measurements revealed negligible interferences from various organic and ionorganic anions. Direct potentiometry and potentiometric titration method of mefenamic acid in capsule preparations are presented and compared.

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Potentiometric Sensor for the Determination of Dibucaine in Pharmaceutical Preparations and Electrochemical Study of the Drug with BSA

  • Ensafi, Ali A.;Allafchian, A.R.
    • Bulletin of the Korean Chemical Society
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    • v.32 no.8
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    • pp.2722-2726
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    • 2011
  • Plasticized poly(vinyl chloride), PVCs, with different membrane compositions tested for use in the construction of an ion-selective sensor for the determination dibucaine. A prepared membrane with dioctyl phthalate-PVC and ion-pair of N-(1-naphthyl)ethylenediamine dihydrochloride-tetraphenyl borate had a good potential to acts as a potentiometric sensor for the analysis of dibucaine. A linear relationship was obtained between potential and logC varying between $1.0{\times}10^{-6}$ and $1.0{\times}10^{-2}$ M dibucaine with a good repeatability and reproducibility. The sensor was applied for the determination of the drug in pharmaceuticals and biological fluids such as plasma and urine samples with satisfactory results. The drug electrode has also been used to study the interaction of bovine serum albumin (BSA) with dibucaine. The saturated quantities of dibucaine binding were 13.04, 5.30 and 9.70 mol/mol in 0.01, 0.02 and 0.1% of protein, respectively.

Preparation of a Liquid Membrance Type Ion-Selective Electrode and Its Application to the Potentiometric Titration (액체막형 구리이온 선택성 전극의 제작과 전위차적정에의 응용)

  • Heung Lark Lee;Seung Tae Yang
    • Journal of the Korean Chemical Society
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    • v.29 no.2
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    • pp.137-143
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    • 1985
  • Construction of a liquid membrane type of cupric ion selective electrode and its application to the potentiometric titration have been studied. A liquid ion-exchange membrance was prepared by extracting Cu(II) in aqueous solution into 1-(2-pyridylazo)-2-naphthol/nitrobenzene. A Ag/AgCl internal reference electrode was dipped into the aqueous reference solution of $1.00 {\times} 10^{-3}M\;Cu(NO_3)_2$ buffered with HAc-NaAc buffer solution, which was in contact with the nitrobenzene extract. The electrode showed the nernstian response to Cu(II) in the concentration range from $1.00{\times} 10^{-6}$ to $1.00{\times} 10^{-3}$M. The most suitable ion-exchanger concentration in the liquid membrane was $1.00{\times} 10^{-4}$M. The selectivity coefficients of the electrode for the various metal cations were investigated. The electrode was applied to the potentiometric titration of Cu(II) with EDTA.

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The Polymer Membrane Electrode by Surfactants for Measuring Continuously Thiocyanate Ion in Wastewater (폐수중 티오시안산이온을 측정하기 위한 계면활성제를 이용한 고분자 막전극)

  • 최종석;안형환;강안수;우인성;황명환
    • Journal of the Korean Society of Safety
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    • v.6 no.4
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    • pp.13-20
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    • 1991
  • Ion-selective electrode responsive to the thiocynate ion prepared by using the quaternary ammonium salts as a active material and PVC as a membrane matrix. The effect of chemical structure and composition of active material, and the membrane thickness on the linear response. the detection limit, and Nernstian slope of the electrode studied. Under the above optimum conditions of membrane, the effect of pH and the selectivity coefficients to various interfering anions were compared and investigated. It was concluded that the functions of thiocynate ion-selective electrode(ISE) were closely related to the chemical structure of the quaternary ammonium salts. The linear response, and the detection limit of the electrode potential increased with the increase of the carbon chain length of the alkyl group in the quaternary ammonium salts in the ascending order of Aliquat 336T, TOAT, TDAT, and TDDAT. The optimum membrane thickness was 0.3mm. The electrode characteristics was better with the decrease of the concentration of active material, and the best concentration was 3 weight percent. The membrane potential was independent of the pH variation in the region from pH 2 to 12. The order of the selectivity coefficients is as follows:Cl $O_4$$^{[-10]}$$I^{[-10]}$ >N $O_3$$^{[-10]}$ >B $r^{[-10]}$$F^{[-10]}$ >C $l^{[-10]}$ >O $A_{c}$ $^{[-10]}$ 〓S $O_4$$^{2-}$.

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Development of a Fluoride-Selective Electrode based on Scandium(III) Octaethylporphyrin in a Plasticized Polymeric Membrane

  • Kang, Young-Jea;Lutz, Christopher;Hong, Sung-A;Sung, Da-Yeon;Lee, Jae-Seon;Shin, Jae-Ho;Nam, Hak-Hyun;Cha, Geun-Sig;Meyerhoff, Mark E.
    • Bulletin of the Korean Chemical Society
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    • v.31 no.6
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    • pp.1601-1608
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    • 2010
  • A scandium(III) porphyrin-based fluoride-selective potentiometric sensor and its application in the analysis of hydrofluoric acid is described. Scandium(III) octaethylporphyrin, an ionophore recently developed for the optical fluoride sensor, was employed as a host molecule for the selective binding with fluoride in the plasticized PVC membrane. Nernstian response for $F^-$ between $10^{-4.6}$ to $10^{-1}$ M was observed at a glycine-phosphate buffer (pH 3.0). The selectivity pattern was observed as $F^-$, salicylate $\gg$ $SCN^-$ > $Cl^-$, $Br^-$, $NO_3{^-}$, $ClO_4{^-}$, which is consistent with the binding constant data measured in the plasticized PVC membrane based on a sandwich membrane method. This highly selective and reversible fluoride-sensitive electrode was employed for the analysis of hydrofluoric acid (HF). A disposable differential-type HF sensor was fabricated on the screen-printed electrode and demonstrated its ability to detect the neutral HF in the acidic solution.

Novel Thallium(I)-Selective Membrane Electrode Based on a Podal Ligand

  • Ganjali, Mohammad Reza;Pourjavid, Mohammad Reza;Mouradzadegun, Arash;Hosseini, Morteza;Mizani, Farhang
    • Bulletin of the Korean Chemical Society
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    • v.24 no.11
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    • pp.1585-1589
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    • 2003
  • A PVC-based membrane electrode for thallium(I) ions based on 1,21,23,25-tetramethyl-2,20: 3,19-dimetheno-[H, 2] H, 23H, 25H-bis-[1,3] dioxocino[5,4-i:5',4'-i] benzo [1,2-d: 5.4-d'] bis [1,3] benzodioxocin(II) has been prepared. The electrode displays a linear dynamic range of $1.0{\times}10^{-1}-1.0{\times}10^{-5}$ M, with a Nernstian slope of $59.8{\pm}0.2\;mV\;{decad^-1}$, and a detection limit $5.0{\times}10^{-6}$ M. It has a very fast response time of<10 s and can be used for at least ten weeks without a considerable divergence in potentials. This electrode revealed comparatively good selectivity with respect to alkali, alkaline earth, and some transition and heavy metal ions and was effective in a pH range of 2.0-10.0. It was used as an indicator electrode in potentiometric titration of thallium ion with sulfide ion.

Ion-Selective Electrodes in Drugs Analysis: Verapamil-Selective Polymeric Membrane Electrodes Based on Calix[4]arene and Dibenzo-18-crown-6-ether Ionophores (이온 선택성 전극을 이용한 의약품 정량: Calix[4]arene과 Dibenzo-18-crown-6-ether에 의한 verapamil-선택성 polymeric membrane electrode)

  • 이은엽;김성진;김영학;김재현;허문회;안문규
    • YAKHAK HOEJI
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    • v.39 no.1
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    • pp.61-67
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    • 1995
  • PVC membrane electrodes based on the lipophilic neutral carrier, dibenzo-18-crown-6, cyclic oligomers of teit-butylphenol-formaidehyde condensates, calix[4]arenes as the active sensors for verapamil have been prepared and tested in a variety of plasticizers. At pH 5.0, the electrode exhibits a Nernstian response in the range of 10$^{-2}$~5$\times$10$^{-5}$ M verapamil with a slope of 49.1$\pm$0.5mV per concentration decade. The electrode constructed in this work can be used continuously for at least 1 month before any damage to the membrane occurs. And the analyses of the local anesthetic amine, which are good to select a specific compound in a mixed solution, were also accomplished by using of another neutral carrier, a DB18C6, for comparing with calix[4]arene.

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Electrode Characteristics of K+ Ion-Selective PVC Membrane Electrodes with AC Impedance Spectrum (AC 임피던스 분석법을 이용한 K+ 이온선택성 PVC막 전극 특성)

  • Kim, Yong-Ryul;An, Hyung-Hwan;Kang, An-Soo
    • Applied Chemistry for Engineering
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    • v.9 no.6
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    • pp.870-877
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    • 1998
  • With impedance spectrum measurements, impedance was studied in the interface between sample solutions for $K^+-ion$ selective PVC membrane electrode containing neutral carriers [dibenzo-18-crown-6 (D18Cr6) and valinomycine (Val)]. Response characteristics of electrode were examined by measuring AC impedance spectra that were resulted from the chemical structure and the content of carrier, variation of plasticizer, membrane thickness, doping of base electrolytes, and concentration variation of sample solution. Transport characteristics of PVC membrane electrode were also studied. It was found that the equivalent circuit for the membrane in $K^+$ solution could be expressed by a series combination of solution resistance and a parallel circuit consisting of the bulk resistance and geometric capacitance of the membrane system. But the charge transfer resistance and Warburg resistance were overlapped a little in the low concentration and low frequency ranges. The carrier, D18Cr6 was best for electrode and impedance characteristics, and ideal electrode characteristics were appeared especially in case of doping of the base electrolyte[potassium tetraphenylborate(TPB)]. The optimum carrier content was about 3.23 wt% in case of D18Cr6 and Val. DBP was best as a plasticizer. As membrane thickness decreased the impedance characteristics was improved, but electrode characteristics were lowered for membrane thickness below the optimum. In the case of D18Cr6, the selectivity coefficients by the mixed solution method for the $K^+$ ion were the order of $NH_4{^+}>Ca^{2+}>Mg^{2+}>Na^+$.

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