• Title, Summary, Keyword: liver-protective

Search Result 735, Processing Time 0.05 seconds

Protective effects of Jucha-whan on liver injury of guinea pigs induced by $CCl_4$ and d-galactosamine (주차환(舟車丸)이 $CCl_4$ 및 d-galactosamine으로 유발된 흰쥐의 간손상(肝損傷)에 미치는 영향)

  • Kang Jae-Chun;Choi Eun-Ju
    • The Journal of Internal Korean Medicine
    • /
    • v.24 no.1
    • /
    • pp.55-67
    • /
    • 2003
  • Objective : In order to investigate the curative effect of Jucha-whan on the protective liver of guinea pigs induced by $CCl_4$ and d-galactosamine, serum transaminase(GOT, GPT), lactic dehydrogenase(LDH), alkaline phosphatase(ALP), glutathione S-transferase(GST), superoxide dismutase(SOD) were used to measure enzyme activities and lipid peroxide level. Method : The subject animals were divided into 5 groups; a control group(untreated), a subject group(administered with 0.9% Saline solution), a sample I (500mg/kg administered), sample II group (1000mg/kg administered), positive control group(administered with 200mg/kg silymarine). Result : The inhibitory effects on the serum GOT, LDH, ALP, SOD and Lipid peroxide level activities in protective liver of mice induced by $CCl_4$ were noted both in the sample I group and sample II. The inhibitory effects on the serum GPT activities in protective liver of guinea pigs induced by $CCl_4$ were noted in sample II group, but it was not noted in the sample I. The inhibitory effects on the GST activities in protective liver of guinea pigs induced by $CCl_4$ were not noted in both sample I and sample group II. The inhibitory effects on the serum GOT, GPT activities in protective liver of guinea pigs induced by d-galactosamine were noted in both sample I and sample II, but it was not recognizable statistically. The inhibitory effects on the serum LDH activities in protective liver of guinea pigs induced by d-galactosamine were noted in sample II, but it was not noted in sample I group. Conclusion : According to the above results, it is considered that Jucha-whan has treatment effects on liver injury in guinea pigs induced by $CCl_4$ and d-galactosamine. So it is required to study about the actions of mutual relation of medicines and patho-mechanism through experiment.

  • PDF

Effects of Galhwahyejung-tang (GHT) on Protection for Alcohol-induced Liver Injury

  • Ahn Tae-Kyu;Shin Jang-Woo;Cho Chong-Kwan;Cho Jung-Hyo;Yoo Hwa-Seung;Lee Yeon-Weol;Lee Nam-heon;Yun Dam-hee;Son Chang-Gue
    • The Journal of Korean Medicine
    • /
    • v.26 no.1
    • /
    • pp.76-84
    • /
    • 2005
  • Objective: The purpose of this study was to examine the protective efficacy of GHT on alcoholic liver injury. Methods: We measured the rate of alcohol oxidation, serum level of liver enzyme, lipid peroxidation level in liver tissue, and inflammatory related cytokine expressions in the liver. Results : GHT showed liver protective effects, lowered the levels of AST and LDH in serum and inhibited lipid peroxidation in liver tissue, and enhanced alcohol oxidation. GHT treatment up-regulated IL-10 in the liver, whereas it down­regulated $TNF-\alpha,\;TGF-\beta$, and Fas ligand. Conclusion : From these results, GHT is presumed to work in the liver in protective roles not through the pathway of alcohol metabolism but mainly by anti-inflammation activity in our model.

  • PDF

The Liver Protective Activities of Some Iranian Medicinal Plants Against Liver Damage in Mice Induced by $CCL_4$ Intoxication

  • Kalantari. H.;Aghel. N.;Annafecheh. M.;Mar, Woong-Chon;Chang, Il-Moo
    • Toxicological Research
    • /
    • v.11 no.2
    • /
    • pp.309-313
    • /
    • 1995
  • The aim and objective of this study are to carry out the liver protective activities against the $CCl_4$ intoxication in mice with some Iranian medicinal plants traditionally used for liver injuries. The methanol extracts of Cichorium intybus, Lactuca scarJoia, Eucalyptus camadulensis were evaluated. With various doses of these plants, liver protective activities were performed after $CCl_4$ administration to mice. The serum aminotransferases activites, liver sizes, and histopatological examinations of liver were studied. At a dose of 50 mg/ kg, all three plants were able to protect liver damages induced by $CCl_4$.

  • PDF

Anti-lipid Peroxidation and Liver Protective Effects of Polygonum aviculare L. (마디풀(Polygonum aviculare L.) 성분의 지질과산화억제 및 간보호에 미치는 효과)

  • Choi, Hyuck-Jai;Kim, Jong-Woo;Hong, Nam-Doo;Kim, Nam-Jae
    • Korean Journal of Pharmacognosy
    • /
    • v.28 no.3
    • /
    • pp.117-123
    • /
    • 1997
  • The ethylacetate fraction of the overground portion of Polygonum aviculare L. exhibited the anti-lipid peroxidation and the liver protective effect in intoxicated rats. Through silica gel chromatography of the ethylacetate fraction monitered by bioassay, two flavonoids, avicularin and juglanin were isolated as active components. Avicularin and juglanin remarkablely inhibited the lipid peroxidation of rat liver induced by 50% ethanol. Especially avicularin exhibited the stronger anti-lipid peroxidation effect than juglanin. Avicularin as a main principle of Polygonum aviculare L. significantly exhibited liver protective activities by decreasing s-GOT and s-LDH levels which represent for the hepatotoxicity induced by $CCl_4$ in rats. In addition, avicularin significantly decreased not only s-LDH but also s-bilirubin levels in intoxicated rat induced by ${\alpha}-naphthylisothiocyanate\;(ANIT)$. These results suggest that avicularin has the protective effects against the hepatoxicity induced by $CCl_4$ and ANIT in rats.

  • PDF

Effects of Alismatis Rhizoma Extracts on Lipid Components in Experimental Liver Injury (실험적 간장해에 의한 지질 함량 변동에 대한 택사 추출액의 영향)

  • Seo, Min-Ji;Ha, Hun;Yoon, Soo-Hong
    • Environmental Analysis Health and Toxicology
    • /
    • v.10 no.3_4
    • /
    • pp.15-20
    • /
    • 1995
  • The protective and therapeutic effects of Alismatis Rhizoma extracts on rat liver injury induced by carcinogenic polycyclic hydrocarbon, benzo(a)pyrene were investigated in rats. Serum and liver triglyceride, total-cholesterol level and serum HDL-cholesterol content were measured. Alismatis Rhizoma extracts inhibited the enhanced production of lipid in chemically induced liver injury. Among 4 fractions, CHCh fraction revealed the most powerful liver-protective effect. Our results strongly suggest that Alismatis Rhizoma be a promising liver-protective agent.

  • PDF

Protective Effects of Some Phytobased Polysaccharides on the Acute Hepatic Damages of ICR-Mice Induced by the Administration of Carbon Tetrachloride and D-Galactosamine (수종 식물성 다당류의 사염화탄소 및 D-Galactosamine 유발 급성 간손상 보호작용)

  • 문창규;안미영;정진호
    • YAKHAK HOEJI
    • /
    • v.29 no.1
    • /
    • pp.43-49
    • /
    • 1985
  • Polysaccharides obtained from Sappan Lignum, Mori Radicis Cortex and Olibanum were examined for their liver protective effects against carbon tetrachloride-and D-galactosamine intoxication in ICR-mice. Hexobarbital sleeping time and serum transaminases (S-GOT and S-GPT) were measured as parameters for the evaluation of liver protective effects. All polysaccharides tested in this experiment showed remarkable positive effects on the prevention of hepatic intoxication with carbon tetrachloride-and D-galactosamine. Much better liver protective effects of polysaccharides were observed in D-galactosamine-liver injuries than in carbon tetrachloride-injuries.

  • PDF

Effect of Kamihaengche-tang Plus Yukmijihwang-tang Oxidant-induced Liver Cell injury (Oxidant에 의한 간독성유발에 가미행체엽탕 합 육미지황탕의 효과)

  • 이수행;김우환
    • Journal of Life Science
    • /
    • v.8 no.4
    • /
    • pp.464-471
    • /
    • 1998
  • This study was carried out to determine whether Kamihaengche-tang plus Yukmijihwang-tang (KCYH) exerts the protective effect against oxidant-induced liver cell injury. Cell injurt was estimated by measuring lactate dehydrogenase (LDH) and alanine aminotransferase (ALT) release, and lipid peroxidation was estimated by measuring malondialdehyde, a product of lipid peroxidation in rabbit liver slices. $H_2O_2$increased LDH release which was significantly prevented by 1% KCYHT. The protective effect of KCYH against $H_2O_2$-induced cell injury was dose-dependent in the range of 0.05-1% concentrations. Similary, KCYH inhibited $H_2O_2$ induced lipid peroxidation in a dose-dependent manner. When liver tissuse were exposed to Hg(0.5 mM), ALT activity in the medium and lipid erpoxidation in tissues were markedly increased. These changes were prevented by 1% KCYH. KCHY restored Hg-induced inhibition of cellular GSH content. These result indicate that KCYH exerts the protective effect oxidant-induced liver cell injury, and this effect is attributed to prevented to prevention of lipid peroxidation. These dffects may be due to an increase in concentration of endogenous antioxidants.

  • PDF

Protective Effect of Yangguksanwha-tang Metabolized by Liver Homogenate on Hypoxia-reperfusion Induced PC12 Cell Damage (간효소에 의해 대사된 양격산화탕의 저산소/재관류로부터 PC12 세포 보호효과)

  • Soh Yunjo
    • YAKHAK HOEJI
    • /
    • v.49 no.1
    • /
    • pp.97-102
    • /
    • 2005
  • The protective effect of Yangguksanwha-tang (YST) against hypoxia-reperfusion insult was investigated in PC12 cells. To elucidate the mechanism of the protective effect of YST, cell viability, the changes in activities of superoxide dismutase, glutathione peroxidase, catalase, caspase 3 and the production of malondialdehyde were observed after treating PC12 cells with YST which was metabolized by rat liver homogenate. Pretreatment of YST with liver homogenate appeared to increase its protective effect against hypoxia-reperfusion insult. The result showed that YST had the highest protective effect against hypoxia/reperfusion at the dose of $2\;{\mu}g/ml$ in PC12 cells, probably by recovering the redox enzyme activities and MDA to control level.

Liver-protective Activities of Alisol Compounds against $CCl_4$ Intoxication (택사(澤瀉)로부터 분리(分離)한 Alisol 성분(成分)의 간(肝) 보호작용(保護作用))

  • Chang, Il-Moo;Kim, Young-Soo;Yun, Hye-Sook;Kim, Sun-Ok
    • Korean Journal of Pharmacognosy
    • /
    • v.13 no.3
    • /
    • pp.112-115
    • /
    • 1982
  • Alisol A monoacetate, alisol B monoacetate, alisol C monoacetate and alisol B were isolated from Alismatis Rhizoma, which is a herbal drug used frequently in the oriental prescriptions. Potential liver-protective activities of the isolated alisol compounds were evaluated against $CCl_4-induced$ liver damage. The results obtained from liver microsomal enzyme assay, measurement of serum glutamic pyruvic transaminase (EC 2.6.1.2) and serum triglyceride content indicated that alisol A,B and C monoacetates showed significant liver-protective activities against $CCl_4$ poisoning. Alisol B monoacetate exhibited slightly higher activity than that of alisol B.

  • PDF

Anti-lipid Peroxidation and Liver Protective Effects of Polygonum aviculare L. (마디풀(Polygonum aviculare L.)의 전초가 지질과산화(脂質過酸化) 및 간기능(肝機能)에 미치는 영향)

  • Lee, Chung-Gi;Kim, Nam-Jae;Hong, Nam-Doo;Kwon, Chang-Ho
    • Korean Journal of Pharmacognosy
    • /
    • v.25 no.1
    • /
    • pp.59-69
    • /
    • 1994
  • Polygonum aviculare L. was extracted by methanol and then fractionated systematically with solvents and column chromatographic method in order to isolate ingredients with anti-lipid peroxidation and liver protectective effects. Among these fractions, ethylacetate soluble part(MWE) showed the strongest in the anti-lipid peroxidation. Furthermore, the crude subtraction(MWE 4) with Rf value near 0.42, which is separated from MWE by column chromatography using a solvent system, inhibited the lipid peroxidation of rat liver in vitro. Moreover, MWE 4 decreased GOT, GPT and TBA value compared with control and suggested high protective effects against hepatotoxicity induced by carbon tetrachloride in mice. The active compounds in MWE 4 were assumed to be flavonoid glucosides.

  • PDF