• Title, Summary, Keyword: macrocyclic ligand

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Resin Synthesis of Adsorbent Uranium(VI) Ion using 1-Aza-18-Crown-6 (1-Aza-18-Crown-6를 이용한 우라늄(VI) 이온 흡착제 수지 합성)

  • Kim, Sun-Hwa;Kim, Hae-Jin
    • Journal of environmental and Sanitary engineering
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    • v.21 no.4
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    • pp.49-60
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    • 2006
  • The ion exchange resins have been synthesized from chlormethyl styrene - 1,4 - divinylbenzene(DVB) with 1%, 2%, 4% and 8%-crosslinking and 1-aza-18-crown-6 macrocyclic ligand by copolymerization method. Content of chlorine in styrene-DVB copolymer was decreased as crosslink increased and it is because as crosslink increased 1%, 2%, 4% and 8% DVB content increased and crosslink density increased and cavity was reduced. Functional group of resin almost disappeared as C-C1 peak around $700cm^{-1}$ was substituted with 1-aza-18-C-6 macrocyclic ligand and new peak of C-N around $1020cm^{-1}$ appeared, so it was confirmed that styrene-DVB copolymer and ligand were compounded. As crosslink increased in the analysis of element contents, it resulted in the reduction of nitrogen content and it is because as crosslink increased, it led to the reduction of chlorine content in the process of substitution reaction and it affected macrocyclic ligand substituted. Thermo analysis curve of functional synthetic resin decomposed three part of 1-aza-18-C-6, styrene, and DVB. Form of functional synthetic resin showed distortion of its particles as macrocyclic ligand was introduced to styrene-DVB copolymer and hydrogen of ligand caused substitution with chlorine element of styrene molecule.

In vivo Imaging Biodistribution Profile of a New Macrocyclic Gadolinium Chelate as a Highly Stable Multifunctional MRI Contrast Agent

  • Sung, Bo Kyung;Jo, Yeong Woo;Chang, Yongmin
    • Investigative Magnetic Resonance Imaging
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    • v.23 no.1
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    • pp.34-37
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    • 2019
  • Gadolinium contrast agents (CAs) are integral components of clinical magnetic resonance imaging (MRI). However, safety concerns have arisen regarding the use of gadolinium CAs, due to their association with nephrogenic systemic fibrosis (NSF). Furthermore, recently the long-term retention of $Gd^{3+}-based$ CAs in brains patients with normal renal function raised another possible safety issue. The safety concerns of $Gd^{3+}-based$ CAs have been based on the ligand structure of $Gd^{3+}-based$ CAs, and findings that $Gd^{3+}-based$ CAs with linear ligand structures showed much higher incidences of NSF and brain retention of CAs than $Gd^{3+}-based$ CAs with macrocyclic ligand structure. In the current study, we report the in vivo biodistribution profile of a new highly stable multifunctional $Gd^{3+}-based$ CA, with macrocyclic ligand structure (HNP-2006). MR imaging using HNP-2006 demonstrated a significant contrast enhancement in many different organs. Furthermore, the contrast enhanced tumor imaging using HNP-2006 confirmed that this new macrocyclic CA can be used for detecting tumor in the central nervous system. Therefore, this new multifunctional HNP-2006 with macrocyclic ligand structure shows great promise for whole-body clinical application.

Designing and Synthesis of Antifungal Active Macrocyclic Ligand and Its Complexes Derived from Diethylphthalate and Benzidine

  • Raman, N.;Parameswari, S.
    • Mycobiology
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    • v.35 no.2
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    • pp.65-68
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    • 2007
  • Three novel complexes of Cu(II), Co(II) and Zn(II) using a macrocyclic ligand derived by the condensation of diethylphthalate and benzidine have been designed, synthesized and characterized by UV-Vis., IR, Mass and Elemental analyses data in order to find out their antifungal activities. The stoichiometry of the complexes has been found to be 1:1 (Metal: Ligand). The analytical data indicate that the complexes exhibit square-planar geometry. The antifungal activity of the macrocyclic ligand and its metal complexes has been screened in vitro against fungi such as Aspergillus niger, A. flavus, Trichoderma harizanum, T. viridae and Rhizoctonia solani.

Template Synthesis and Characterization of Copper(Ⅱ) Complexes of a Polyaza Non-Macrocyclic or a Bis(macrocyclic) Ligand

  • 강신걸;유기석;정수경;김창수
    • Bulletin of the Korean Chemical Society
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    • v.17 no.4
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    • pp.331-334
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    • 1996
  • New copper(Ⅱ) complex of the pentaaza non-macrocyclic ligand 1-(2-aminoethyl)-3-(N-{2-aminoethyl}aminomethyl)-1,3-diazacyclohexane (2) and a dinuclear copper(Ⅱ) compex of the bis(macrocyclic) ligand 3, in which two 1,5,8,10,12,15-hexaazabicyclo[11.3.11.5]heptadecane subunits are linked together by an ethylene chain through the uncoordinated nitrogen (N10) atoms, have been prepared selectively by the reaction of the metal ion, 1,4,8-triazaoctane, ethylenediamine, and formaldehyde. The dinuclear complex [Cu2(3)]4+ has been also prepared by the reaction of [Cu(2)]2+ with ethylenediamine and formaldehyde. The reaction products largely depend on the molar ratio of the reactants employed. The mononuclear complex or each macrocyclic subunit of the dinuclear complex contains one 1,3-diazacyclohexane ring and has a square-planar geometry with a 5-6-5 or 5-6-5-6 chelate ring sequence. In acidic solution, the copper(Ⅱ) complex of 2 dissociates more slowly than those of other related non-cyclic polyamines.

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Resin Synthesis of Adsorbent Metal Ions using 1-Aza-12-Crown-4 (1-Aza-12-Crown-4를 이용한 금속 이온 흡착제 수지 합성)

  • Kim Joon-Tae;Roh Gi-Hwan
    • Journal of environmental and Sanitary engineering
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    • v.19 no.3
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    • pp.52-57
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    • 2004
  • Content of chlorine in s쇼rene-DVB copolymer was decreased as crosslink increased and it is because as crosslink increased $1\%,\;2\%,\;5\%\;and\;10\%$ DVB content increased and crosslink density increased and cavity was reduced. Functional group of resin almost disappeared as C-C1 peak around $700cm^{-1}$ was substituted with 1-aza-12-C-4 macrocyclic ligand and new peak of C-N around $1020cm^{-1}$ appeared, so it was confirmed that styrene-DVB copolymer and ligand were compounded. As crosslink increased in the analysis of element contents, it resulted in the reduction of nitrogen content and it is because as crosslink increased, it led to the reduction of chlorine content in the process of substitution reaction and it affected macrocyclic ligand substituted. Form of functional synthetic resin showed distortion of its particles as macrocyclic ligand was introduced to styrene-DVB copolymer and hydrogen of ligand caused substitution with chlorine element of styrene molecule.

Studies on Reactions of a Nickel Complex of a New Completely Conjugated Macrocyclic Ligand

  • Park, Young-Ae W.;Oh, Soon-Song
    • Bulletin of the Korean Chemical Society
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    • v.8 no.6
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    • pp.476-479
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    • 1987
  • The macrocyclic nickel complex of the molecular formula[Ni($C_{32}H_{26}N_4$)] has been synthesized from the template condensation reaction between 1-benzoylacetone and o-phenylenediamine in the presence of nickel acetate. Protonation and deuterium exchange reactions of the demetallated macrocyclic ligand and the nickel complex have been carried out. The infrared, electronic and proton magnetic resonance spectral data of both compounds are compared and discussed; protonation of the macrocyclic ligand take place at the nitrogen atoms and all the amine protons undergo very rapid deuterium exchange while the methine protons undergo very slow exchange. On the other hand, protonation of the nickel complex occurs at the nitrogen atoms and only amine protons undergo rapid deuterium exchange. Protonation and deprotonation of the nickel complexes proceed reversibly.

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Adsorption of Uranium Ion Utilizing OenNtn-Styrene-DVB Resin (OenNtn-스틸렌-DVB 수지를 이용한 우라늄(VI) 이온의 흡착)

  • 김준태;노기환;강영식
    • Journal of environmental and Sanitary engineering
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    • v.18 no.2
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    • pp.9-15
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    • 2003
  • Resins have been synthesized from chlormethyl styrene 1,4- divinylbenzene(DVB) with 1%, 4%, and 20%-crosslinked and macrocyclic ligand of cryptand type by copolymerization method and the adsorption of uranium(VI), nickel(II) and lutetium(III) ions have been investigated in various experimental conditions. The correlation between the adsorption characteristics of rare earths and transition metal on the resins and stability constants of complexes with macrocyclic ligand have been examined. The uranium ion was not adsorbed on the resins below pH 2.0, but the power of adsorption of uranium ion increased rapidly above pH 3.0. The adsorption power was in the order of 1%, 4% and 20%-crosslinked resin, but adsorptive characteristics of resins decreased in proportion to the order of dielectric constants of solvents.

Adsorption characteristic of uranium(VI) on OenNtn synthetic resin with styrene (Styrene을 이용한 OenNtn수지의 합성과우라늄(VI) 이온 흡착 특성)

  • Kim, Joon-Tae
    • Journal of environmental and Sanitary engineering
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    • v.23 no.2
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    • pp.47-53
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    • 2008
  • The ion exchange resins have been synthesized from chloromethyl styrene (dangerous matter) 1, 4-divinylbenzene(DVB) with 1%, 5%, and 15%-crosslinked and macrocyclic ligand of cryptand type by copolymerization method and the adsorption of uranium(VI), cobalt(II) and europium(III) ions have been investigated in various experimental conditions. The correlation between the adsorption characteristics of rare earths and transition metal on the resins and stability constants of complexes with macrocyclic ligand have been examined. The uranium ion was not adsorbed on the resins below pH 2.0, but the power of adsorption of uranium ion increased rapidly above pH 3.0. The adsorption power was in the order of 1%, 5% and 15%-crosslinked resin, but adsorptive characteristics of resins decreased in proportion to the order of dielectric constants of solvents.

Structure and Properties of a Nonheme Pentacoordinate Iron(II) Complex with a Macrocyclic Triazapyridinophane Ligand

  • You, Minyoung;Seo, Mi Sook;Kim, Kwan Mook;Nam, Wonwoo;Kim, Jinheung
    • Bulletin of the Korean Chemical Society
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    • v.27 no.8
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    • pp.1140-1144
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    • 2006
  • A macrocyclic ligand, N,N',N'-tribenzyl-2,11,20-triaza[3,3,3](2,6)pyridinophane (BAPP), was used to prepare an iron(II) complex as a nonheme model complex, $[(BAPP)Fe]^{+2}$ (1). X-ray crystallography of a colorless crystal of 1 revealed that BAPP acted as a pentadentate ligand due to geometrical strain for the formation of a six-coordinate iron(II) complex by BAPP. As a result, the iron center revealed a significantly distorted square pyramidal geometry similar to that found in the active site of taurine dioxygenase (tauD). In the reaction of 1 with PhIO, no intermediate was observed in the UV-visible region of spectrometer at low temperatures. Catalytic oxidations of triphenyl phosphine with PhIO at ${-40^{\circ}C}$ revealed that 1 was able to convert triphenyl phosphine to triphenyl phosphine oxide.23; SSOCHKThioanisole was also oxidized to the corresponding methylphenyl sulfoxide under the same conditions.