• Title, Summary, Keyword: macroscopic findings

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Macroscopic Serosal Invasion in Advanced Gastric Cancer (진행성 위암에서 육안적 장막침윤의 의의)

  • Yun, Woo-Sung;Kim, Tae-Bong;Yu, Wan-Sik
    • Journal of Gastric Cancer
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    • v.6 no.2
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    • pp.84-90
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    • 2006
  • Purpose: The macroscopic findings of tumors are not always identical with the microscopic findings. This study investigated the oncologic implications of macroscopic serosal invasion in advanced gastric cancer to find out how to improve the accuracy for the depth of invasion assessed by the surgeon during an operation. Materials and Methods: The medical records of 789 patients with advanced gastric cancer who underwent a gastrectomy at Kyungpook National University Hospital between 1995 and 1999 were reviewed. The prognoses and the recurrence patterns were analyzed according to macroscopic serosal invasion and microscopic serosal invasion, and the clinico-pathological factors of cT3/ss cancers were compared with those of cT3/se cancers. Results: Difference of survival rates according to macroscopic serosal invasion and microscopic serosal invasion revealed statistically significant. Recurrence rates were similar in patients with macroscopic and microscopic serosal invasion (42.2% and 41.4%, respectively). Peritoneal recurrence rates were also similar (19.8% and 21.9%, respectively). The sensitivity and the specificity of macroscopic assessment of serosal invasion were 70.3% and 77.8%, respectively, On univariate and multivariate analyses, Borrmann type I/II cancers and the absence of distant metastases revealed the risk factors for overestimating of serosal invasion. Conclusion: Macroscopic serosal invasion assessed by a surgeon intraoperatively can be used to give a prognosis and to predict the recurrence pattern precisely, although there is a risk for overestimation when the tumor is a Borrmann type I/II cancer or the tumor has no distant metastases. (J Korean Gastric Cancer Assoc 2006;6:84-90)

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Fetal Death and Maceration in dog (개의 태아사 및 태아침지)

  • 신창록;손창호;박인철;최한선;강병규
    • Journal of Veterinary Clinics
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    • v.14 no.1
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    • pp.112-117
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    • 1997
  • 12-month-old Buldig and 3-year-old German Shepherd, treated with corticosteroids duringthe late pregnancy, were referred to the Veterinary Teaching Hospital, Chonnam National University, with chief complaints of vaginal discharge. Radiographic, ultrasonographic and surgical findings that obtained from each cases were as follows; case I: Radiographic findings were identified 2 fetuses that were normal skeleton, however, fetal viability could not be determined. Ultrasonographic findings were identified absence of fetal heartbeat and fetal movement, abnormal echogenicity of the abdominal visera, and echogenic materials remaining within the fetal fluid. After hysterotomy, macroscopic findings of uterus were liquefied materials remaining within the uterine lumen. Fetuses were excessively autolysis (falling off the hair, depression of the eye, and necrosis of the abdormal visera and skin). case II: Radiographic findings were identified irregular fetal structures and fetal movement, loss of recognizable fetal anatomy, dislocation of fetal veterbrae and echogenic materials remaining within the uterine lumen. After ovariohysterectomy, macroscopic finding of uterus and fetus were thickened uterine wall, yellowish-brown colored administration of corticosteroids during gestation should be contraindicated because fetal death is inducced. Ultrasonography has an advantage over radiography in that it permits evaluation of fetal viability.

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Impact of Intraoperative Macroscopic Diagnosis of Serosal Invasion in Pathological Subserosal (pT3) Gastric Cancer

  • Kim, Dong Jin;Lee, Jun Hyun;Kim, Wook
    • Journal of Gastric Cancer
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    • v.14 no.4
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    • pp.252-258
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    • 2014
  • Purpose: The macroscopic diagnosis of tumor invasion through the serosa during surgery is not always distinct in patients with gastric cancer. The prognostic impact of the difference between macroscopic findings and pathological diagnosis of serosal invasion is not fully elucidated and needs to be re-evaluated. Materials and Methods: A total of 370 patients with locally advanced pT2 to pT4a gastric cancer who underwent curative surgery were enrolled in this study. Among them, 155 patients with pT3 were divided into three groups according to the intraoperative macroscopic diagnosis of serosal invasion, as follows: serosa exposure (SE)(-) (no invasion, 72 patients), SE(${\pm}$) (ambiguous, 47 patients), and SE(+) (definite invasion, 36 patients), and the clinicopathological features, surgical outcomes, and disease-free survival (DFS) were analyzed. Results: A comparison of the 5-year DFS between pT3_SE(-) and pT2 groups and between pT3_SE(+) and pT4a groups revealed that the differences were not statistically significant. In addition, in a subgroup analysis of pT3 patients, the 5-year DFS was 75.1% in SE(-), 68.5% in SE(${\pm}$), and 39.4% in SE(+) patients (P<0.05). In a multivariate analysis to evaluate risk factors for tumor recurrence, macroscopic diagnosis (hazard ratio [HR], SE(-) : SE(${\pm}$) : SE(+)=1 : 1.01 : 2.45, P=0.019) and lymph node metastasis (HR, N0 : N1 : N2 : N3=1 : 1.45 : 2.20 : 9.82, P<0.001) were independent risk factors for recurrence. Conclusions: Gross inspection of serosal invasion by the surgeon had a strong impact on tumor recurrence in gastric cancer patients. Consequently, the gross appearance of serosal invasion should be considered as a factor for predicting patients' prognosis.

Dynamic Motion of Polyelectrolyte in a Composite Membrane: I. Macroscopic Study (막에서 전하고분자의 동적 현상 I. 거시적 연구)

  • Park, Young
    • Membrane Journal
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    • v.4 no.2
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    • pp.85-95
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    • 1994
  • This papr studies the dynamic effects of polyelectrolyte in the multilayered membrane. It is found that electrophoretic convection in the fluid phase can be used to accelerate the speed of the polyelectrolyte. The model in the membrane separation is studied via interactions between fluid and solid phases. The spectra evaluation using the operator theoretic method is performed for the parametric studies of the physical properties in the membrane process. The findings of this paper shoould be useful in guiding the design of separation devices. This paper shows one example for macroscopic study the theoretical review paper of membrane transport.

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Two Cases of Glomus Tumor Arising in Large Airway: Well Organized Radiologic, Macroscopic and Microscopic Findings

  • Choi, In Ho;Song, Dae Hyun;Kim, Jhingook;Han, Joungho
    • Tuberculosis and Respiratory Diseases
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    • v.76 no.1
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    • pp.34-37
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    • 2014
  • Glomus tumors of the lung are rare benign neoplasm, originating from modified smooth muscle cells. The patients are usually presented with no or non-specific symptoms such as cough, dyspnea or hemoptysis. Although surgical treatment is considered as the treatment of choice, the endobronchial therapy can be applied to the patients who are unfit for surgical excision. Herein, we describe two rare cases of glomus tumor originated at large airway (trachea and main bronchus) without respiratory symptoms and review their characteristic radiologic, macroscopic and pathological features.

SUBACUTE TOXICITY OF HANTABAX (HFRS-VACCINE) IN MICE

  • Moon, Chang-Kiu;Park, Kwang-Sik;Mock, Myung-Soo;Jung, Myung-Kiu;Kim, Ji-Young;Jeong, Ja-Young;Kang, Kyung-Sun
    • Toxicological Research
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    • v.5 no.2
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    • pp.111-121
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    • 1989
  • Subacute toxicity of Hantabax, epidemic hemorrhagic fever vaccine, was investigated in ICR mice with subcutaneous injection. Any significant toxic symptom was not observed in the treated mice during the experimental period. Macroscopic examination on the organs of tested animals showed no abnormal findings. On autopsy, no significant changes were found in all organs examined.

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ACUTE TOXICITY OF HANTABAX (HFRS-VACCINE) IN RATS AND MICE

  • Moon, Chang-Kiu;Park, Kwang-Sik;Mock, Myung-Soo;Jung, Myung-Kiu;Kim, Ji-Young
    • Toxicological Research
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    • v.5 no.2
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    • pp.105-109
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    • 1989
  • Single dose of Hantabax, HFRS-vaccine, was given to both sexes of Sprague-Dawley rats and ICR mice, subcutaneously and intraperitoneally. Any toxic symptom was not noted in the treated animals. Macroscopic examination on the organs of tested animals showed no abnormal findings. In general toxicological aspects Hantabax was practically nontoxic in rats and mice upto a single dose of 1000 times of human clinical dose equivalent via subcutaneous and intraperitoneal administration.

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A Study on The Lesions of The Mammary Glands of Slaughtered Holstein Cows in Gwangju Area (광주지역에서 도태되는 홀스타인 소 유방의 병변 조사)

  • Lee, Chai-yong;Kim, Hye-ra;Lee, Jeong-chi;Kim, Sang-ki;Lee, Chung-gil;Kim, Jong-taek
    • Korean Journal of Veterinary Research
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    • v.43 no.2
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    • pp.295-299
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    • 2003
  • Macroscopic investigations were made on the lesions of a total of 101 udders from slaughtered Holstein cows in Gwangju area. Incidence of supernumerary teats was 9.9%. Gross lesions were found in the surface of teats of 29.4% of cows; these lesions comprised papilomatosis (16.0%), fronds (8.9%) and injury at the tip (3.2%). Approximately 95% of the cows had slight to severe teat orifice keratosis. On the mucous membranes of the teat cisterns, fibrosis (22.7%) and congestion (8.9%) were observed. Gross lesions were found in the mammary glands of 68% of cows; these lesions comprised fibrosis (18.8%), serous exudate (4.9%), fatty tissue (4.9%), pus (4.0%), congestion (2.0%).