• Title, Summary, Keyword: metacyclic

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CONJUGACY CLASSES OF SUBGROUPS OF SPLIT METACYCLIC GROUPS OF PRIME POWER ORDER

  • Sim, Hyo-Seob
    • Bulletin of the Korean Mathematical Society
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    • v.35 no.4
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    • pp.719-726
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    • 1998
  • In this paper, we consider conjugacy of subgroups of some split metacyclic groups of odd prime power order to determine the numbers of conjugacy classes of subgroups of those groups. The study was motivated by the linear isomorphism problem of metacyclic primitive linear groups.

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IRREDUCIBLE REPRESENTATIONS OF SOME METACYCLIC GROUPS WITH AN APPLICATION

  • Sim, Hyo-Seob
    • East Asian mathematical journal
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    • v.33 no.1
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    • pp.45-52
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    • 2017
  • Motivated by the problem of determining all right ideals of a group algebra FG for a finite group G over a finite field F, we explicitly determine the faithful irreducible representations of some finite metacylic groups over finite fields. By using that result, we determine the structure of all right ideals of the group algebra for the symmetric group $S_3$ over a finite field F, as an example.

Identification of novel Leishmania major antigens that elicit IgG2a response in resistant and susceptible mice

  • MOHAMMADI Mohammad Reza;ZEINALI Majid;ARDESTANI Sussan K.;KARIMINIA Amina
    • The Korean Journal of Parasitology
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    • v.44 no.1
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    • pp.43-48
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    • 2006
  • Experimental murine models with high, intermediate and low levels of genetically based susceptibility to Leishmania major infection reproduce almost entire spectrum of clinical manifestations of the human disease. There are increasing non-comparative studies on immune responses against isolated antigens of L. major in different murine strains. The aim of the present study was to find out whether there is an antigen that can induce protective immune response in resistant and susceptible murine strains. To do that, crude antigenic extract of procyclic and metacyclic promastigotes of L. major was prepared and subjected to SDS-PAGE electrophoresis. Western-blotting was used to search for antigen(s) capable of raising high antibody level of IgG2a versus IgG1 in the sera of both infected resistant and susceptible strains. Two novel antigens from metacyclic promastigotes of L. major (140 and 152 kDa) were potentially able to induce specific dominant IgG2a responses in BALB/c and C57BU6 mice. The 2 antigens also reacted with IgG antibody of cutaneous leishmaniasis patients. We confirm that 140 and 152 kDa proteins of L. major promastigotes are inducing IgG production in mice and humans.

Effects of combined therapy with thalidomide and glucantime on leishmaniasis induced by Leishmania major in BALB/c mice

  • SOLGI Ghassem;KARIMINIA Amina;ABDI Khossro;DARABI Majid;GHAREGHOZLOO Behnaz
    • The Korean Journal of Parasitology
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    • v.44 no.1
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    • pp.55-61
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    • 2006
  • For treating Leishmania major infection in BALB/c mice, we used thalidomide in conjunction with glucantime. Groups of mice were challenged with $5{\time}10^3$ metacyclic promastigotes of L. major subcutaneously. A week after the challenge, drug treatment was started and continued for 12 days. Thalidomide was orally administrated 30 mg/kg/day and glucantime was administrated intraperitoneally (200 mg/kg/day). It was shown that the combined therapy is more effective than single therapies with each one of the drugs since the foot pad swelling in the group of mice received thalidomide and glucantime was significantly decreased (0.9 :t 0.2 mm) compared to mice treated with either glucantime, thalidomide, or carrier alone (1.2 :t 0.25, 1.4 :t 0.3, and 1.7 :t 0.27 mm, respectively). Cytokine study showed that the effect of thalidomide was not dependent on IL-12; however, it up-regulated IFN-yand down-regulated IL-10 production. Conclusively, thalidomide seems promising as a conjunctive therapy with antimony in murine model of visceral leishmaniasis.

Production of nitric oxide by murine macrophages induced by lipophosphoglycan of Leishmania major

  • KAVOOSI Gholamreza;ARDESTANI Sussan K.;KARIMINIA Amina;TAVAKOLI Zahra
    • The Korean Journal of Parasitology
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    • v.44 no.1
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    • pp.35-41
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    • 2006
  • Protozoan parasites of the genus Leishmania cause a number of important human diseases. One of the key determinants of parasite infectivity and survival is the surface glycoconjugate lipophosphoglycan (LPG). In addition, LPG is shown to be useful as a transmission blocking vaccine. Since culture supernatant of parasite promastigotes is a good source of LPG, we made attempts to characterize functions of the culture supernatant, and membrane LPG isolated from metacyclic promastigotes of Leishmania major. The purification scheme included anion-exchange chromatography, hydrophobic interaction chromatography and cold methanol precipitation. The purity of supernatant LPG (sLPG) and membrane LPG (mLPG) was determined by SOS-PAGE and thin layer chromatography. The effect of mLPG and sLPG on nitric oxide (NO) production by murine macrophages cell line (J77 4.1 A) was studied. Both sLPG and mLPG induced NO production in a dose dependent manner but sLPG induced significantly higher amount of NO than mLPG. Our results show that sLPG is able to promote NO production by murine macrophages.