• Title, Summary, Keyword: multicentric lymphoma

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A T-cell type multicentric Lymphoma affecting central nervous system in a Cocker Spaniel dog

  • Kim, Ju-Won;Jung, Dong-In;Kang, Byeong-Teck;Yoo, Jong-Hyun;Park, Chul;Kim, Dae-Young;Park, Hee-Myung
    • Korean Journal of Veterinary Research
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    • v.48 no.3
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    • pp.363-367
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    • 2008
  • A 4-year-old female Cocker spaniel was presented with respiratory distress and abdominal distension. Pleural effusion, ascites, hepatosplenomegaly, and superficial lymphadenopathy were observed and multicentric lymphoma was diagnosed by cytological examination. Immunophenotyping of lymph node and bone marrow using polymerase chain reaction for antigen receptor rearrangement identified a stage V lymphoma originating from T-cell. Despite of systemic chemotherapy using L-asparagenase, vincristine, cyclophoaphamide and prednisolone, neurologic deficits came out and progressed. Cerebrospinal fluid analysis revealed neoplastic lymphocytic pleocytosis indicating central nervous system involvement of lymphoma. The postmortem diagnosis was confirmed based on the histology and imunohistochemistry.

Intraocular Lymphoma in a Dog (개의 Intraocular Lymphoma)

  • 우흥명
    • Journal of Veterinary Clinics
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    • v.18 no.4
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    • pp.429-433
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    • 2001
  • Lymphoma is one of the most common malignant neoplasms of the dog. Little has been published on intraocular lymphoma in dogs. This report presents a 8-year-old neutered male mixed dog with a previous history on inflammatory debris on the anterior and posterior lens capsules, vitreal hemorrhage, generalized peri-pheral lymphadenopathy and a palpable mid-abodominal mass. History, clinical signs, radiography, cytology, histopathology and chemotherapeutic response confirmed multicentric lymphoma with secondary ocular infla-mmation. Intraocular lymphoma, the most common secondary neoplasm of the canine eye, may be the present-ing evidence of systemic disease. This report describes a dog that presented with ocular manifestations of multicentric lymphoma.

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Multicentric T cell lymphoma in a Maltese dog

  • Jung, Ji-Youl;Kang, Sang-Chul;Roh, In-Soon;Sohn, Hyun-Joo;Yun, Young-Min;Kim, Jung-Hun;Lee, Kyoung-Kap;An, Min-Chan;Bae, Jong-Hee;Kim, Jae-Hoon
    • Korean Journal of Veterinary Research
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    • v.47 no.1
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    • pp.85-89
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    • 2007
  • A case of multicentric high grade T cell lymphoma is reported in a 5-year-old male Maltese dog with generalized lymphadenopathy. The dog showed depression, anorexia, blindness, jaundice, arrhythmia, and hematuria for 8 months. Complete blood count and chemistry profile revealed anemia and increased alanine transferase, alkaline phosphatase, total bilirubin, and total cholesterol. Grossly, most of lymph nodes, spleen, and liver were enlarged and neoplastic masses were occupied in these tissues. Histologically, massive accumulation of small noncleaved neoplastic lymphocytes with high mitotic figures was observed in all lymph nodes and spleen. Infiltration of neoplastic lymphocytes was also noted in the lung, liver, kidney, eye, skin, muscle, and bone marrow of femur. Immunohistochemistry revealed that tumor cells were CD3-positive and but CD79a-negative, consistent with T-cell lineage. In our best knowledge, this is the first report of multicentric lymphoma clarified the origin of tumor cells in Korea.

Successful Management of a Life Threatening Canine Multicentric Lymphoma with Pulmonary Thromboembolism

  • Moon, Min-Young;Suh, Guk-Hyun;Choi, Hyeong-Il;Kim, Joonyoung;Kim, Ha-Jung
    • Journal of Veterinary Clinics
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    • v.35 no.5
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    • pp.218-221
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    • 2018
  • A 12-year-old, intact female Jindo was referred to our clinic due to the enlargement of all lymph nodes, as well as severe dyspnea. All palpatible lymph nodes were highly swelling and enlargement. The dog was diagnosed as end stage of multicentric lymphoma with multi-organ metastasis. In addition, the dog was diagnosed as having a pulmonary thromboembolism via computed tomography (CT) and D-dimer concentrations and prothrombin time (PT) results. This case report describes that lymphoma can be associated with pulmonary thromboembolism which is life threatening complication in dogs. The present case was managed successfully with chemotherapy and antithrombotic treatment.

A Case of Cervical Malignant Lymphoma Coexisted with Multicentric Castleman's Disease (다발성 캐슬만병과 공존한 경부 악성 림프종 1례)

  • Jang, Gyu Ho;Jung, Young Do;Seo, Youn Tae;Kim, Jeong Kyu
    • Korean Journal of Head & Neck Oncology
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    • v.32 no.2
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    • pp.35-39
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    • 2016
  • Castleman's disease (CD) is an uncommon lymphoproliferative disorder. The disease entity is classified into 2 clinical subtypes, unicentric and multicentric type. Prevalence of lymphoid malignancy in multicentric CD (MCD) is very low. In this case, we report a case of 77 years old woman who developed high fever and swelling in both side of her neck. Neck lymph node biopsy revealed plasma cell hyperplasia. Patient's symptom was subsided after treatment with Dexamethasone. Three months later, multiple lymph node enlargement was developed in abdomen and neck area again. Repeated neck lymph node biopsy confirmed diffuse large B cell lymphoma. The patient started chemotherapy.

Radiographic and Ultrasonographic Images in Canine Lymphoma (개에서 림프종의 방사선학적 및 초음파학적 진단)

  • 이기창;윤정회;최민철
    • Journal of Veterinary Clinics
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    • v.19 no.3
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    • pp.337-341
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    • 2002
  • In 2001, eight small-sized dogs and three medium-sized dogs with or without clinical signs such as vomiting, dyspnea and enlargement of superficial lymph nodes were diagnosed as lymphoma by radiography, ultrasonography and cytology. Among them, six were female mainly over 7 years old and others were male around 4 years old. There were six cases of multicentric form lymphoma, three cases of mediastinal form, an alimentary and an extranodal form, respectively. Radiographic findings were enlarged cranial mediastinal lymph node, sternal lymph node, and tracheobronchial lymph nodes on thorax and hepatomegaly, splenomegaly, and enlarged sublumbar lymph nodes on abdomen. Ultrasonographic findings revealed enlarged abdominal lymph nodes and multifocal hypoechoic lesions on the liver. Especially, severe wall thickness of small bowel was observed in a dog with alimentary lymphoma. Three dogs were dead during chemotherapy, and three dogs were dead without any treatment. Three dogs did not return and two treated dog showed normal status. Radiography and ultrasonography, although not giving an final diagnosis for lymphoma, are useful for assessment and diagnosis of lymphoma.

Application of Low-Budget Protocol with Lomustine and Prednisolone for Multicentric Lymphoma in a Dog (개 다발성 림프종에 대한 Lomustine 및 Prednisolone을 이용한 Low-budget protocol 적용 증례)

  • Lee, Do-Hyung;Lim, Soo-Jung;Son, Sun-Ho;Lee, Sun-Hee;Jun, Hyung-Kyou;Choi, Ho-Jung;Lee, Young-Won;Cho, Sung-Whan;Song, Kun-Ho
    • Journal of Veterinary Clinics
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    • v.26 no.3
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    • pp.263-267
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    • 2009
  • A 9-year-old, female, Maltese Dog(2.15 kg of body weight) was referred to the Veterinary Medical Teaching Hospital, Chungnam National University with cervical masses, abdominal masses and petechia. Physical examination showed masses in mandibular, prescapular, inguinal, popliteal lymph node and abdominal subcutaneous hemorrhage. This case was diagnosed as the multicentric lymphoma by physical examination, laboratory examination, radiography, ultrasonography, CT, fine needle aspiration and histopathologic examination. This dog was treated by low-budget protocol with lomustine and prednisolone. The dog show that response duration and survival time is 143days and 263 days, respectively.