• Title, Summary, Keyword: natural antimicrobial

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Study of Effectiveness of Antimicrobial on Restraining Formation of Biofilms on the Surface of Aluminum (항균제를 이용한 알루미늄 표면에 생물막 형성 억제효과 분석)

  • Park, SangJun;Oh, YoungHwan;Jo, BoYeon;Choi, MiYeon;Hyun, MinWoo;Jeong, JaeHyun;Kim, EuiYong
    • KSBB Journal
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    • v.30 no.2
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    • pp.69-76
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    • 2015
  • The antibacterial activity of a antimicrobial (organic synthetic or organic natural material) on the bacteria (Bacillus megaterium, Arthrobacter oxydans, Micrococcus luteus, Methylobacterium aquaticum) detected in the automobiles showed 99.9% bacteria decrease rate within 30 min of being in contact with the tested bacteria culture. The MIC of the organic synthetic material based antimicrobials and the organic natural material based antimicrobial on the bacteria were 31~500 mg/mL and 8~250 mg/mL, respectively. The bacteria and biofilms were formed on the surface of aluminum after 5 ~8 days in the case of addition of the organic synthetic material based antimicrobial to the MIC values for the tested bacteria culture. On the other hand, there was no proliferation of bacteria and formation of biofilms on the surface of aluminum even after 30 days in the case of addition of the organic natural material based antimicrobial to the MIC values for the tested bacteria culture. As a result, the organic natural material based antimicrobial was confirmed to be more excellent effect of inhibition of bacterial proliferation and restraint of biofilms formation than the organic synthetic material based antimicrobial.

Biological Evaluation of Korean Medicinal Plants (III)

  • Woo, Won-Sick;Lee, Eun-Bang;Han, Byung-Hoon
    • Archives of Pharmacal Research
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    • v.2 no.2
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    • pp.127-131
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    • 1979
  • The extracts of sixty Korean plants were evaluated for their biological activities such as antitumor activities against Sarcoma 180, Leukemia SN-36 and Ehrlich ascites carcinoma, antimicrobial activities and behavioral observation in mice. The results are tabulate.

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Antimicrobial Activity of Antimicrobial Peptide LPcin-YK3 Derived from Bovine Lactophoricin

  • Kim, Ji-Sun;Jeong, Ji-Ho;Cho, Jang-Hee;Lee, Dong-Hee;Kim, Yongae
    • Journal of Microbiology and Biotechnology
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    • v.28 no.8
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    • pp.1299-1309
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    • 2018
  • We previously reported on lactophoricin (LPcin), a cationic ${\alpha}-helical$ antimicrobial peptide derived from bovine milk, which has antimicrobial effects on Candida albicans as well as Gram-positive and Gram-negative bacteria. In this study, we designed the LPcin-YK3 peptide, a shorter analog of LPcin, and investigated its antimicrobial activity. This peptide, consisting of 15 amino acids with + 3 net charges, was an effective antimicrobial agent against the on the Gram-positive strain, Staphylococcus aureus (MIC: $0.62{\mu}g/ml$). In addition, the hemolytic activity assay revealed that the peptide was not toxic to mouse and human erythrocytes up to $40{\mu}g/ml$. We also used circular dichroism spectroscopy to confirm that peptide in the presence of lipid has ${\alpha}-helical$ structures and later provide an overview of the relationship between each structure and antimicrobial activity. This peptide is a member of a new class of antimicrobial agents that could potentially overcome the problem of bacterial resistance caused by overuse of conventional antibiotics. Therefore, it could be used as a therapeutic or natural additive, particularly in the cosmetics industry.

Antimicrobial activity of Mongolian medicinal plants

  • Gonchig, Enkhmaa;Erdenebat, Sarnaizul;Togtoo, Ouyntsetseg;Bataa, Sukhkhuu;Gendaram, Odontuya;Kim, Young-Sup;Ryu, Shi-Yong
    • Natural Product Sciences
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    • v.14 no.1
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    • pp.32-36
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    • 2008
  • The antimicrobial activity of seventy five ethanol extracts obtained from 67 different kinds of plant species of the Mongolian flora were evaluated by means of the disc diffusion method against five species of microorganisms, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, Micrococcus luteus and Pseudomonas aeruginosa. Among the plant extracts examined, 34 kinds of extracts demonstrated significant antibacterial activity against one or more species of microorganisms, respectively. Especially, the root extract of Paeonia anomala, the whole herb extract of Myricaria alopecuroides, the whole herb extract of comarum zalesovianum, the whole herb extract of Agrimonia pilosa and some other plant extracts demonstrated a particularly potent antimicrobial activity. The ethylacetate fractions obtained from the whole herb extract of Myricaria alopecuroides and from those of Sedum aizoon, Paeonia anomala, Sedum hybridum and Dasiphora fruticosa exhibited a particularly potent antibacterial activity especially against Staphylococcus aureus and Micrococcus luteus.

A Study on the Antimicrobial Effect of Natural Artemisia Extract using Super Critical Carbon Dioxide (초임계 이산화탄소를 이용한 쑥 추출물의 항균효과에 관한 연구)

  • Sung, Ki-Chun
    • Journal of the Korean Applied Science and Technology
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    • v.20 no.4
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    • pp.309-315
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    • 2003
  • Extraction of Natural Artemisia by using super critical carbon dioxide is operated under $40-50^{\circ}C$ and 200-250 atm, thus, conversion rate is very low as 7wt% while high energy is being wasted. When Natural Artemisia Extract is applied in the control of microbe, concentration and reaction time greatly affected to the growth of microbe. Especially, when refined oil concentration from Natural Artemisia added more than 1,000ppm, staphylococcus aureus and fungi are terminated completely. Thus, it is proven that Natural Artemisia Extract has antimicrobial effect.

Antimicrobial and Antioxidative Activities of Cornis fructus Extracts

  • Chun, Hyun-Ja;Choi, Won-Hyung;Lee, Jeong-Ho;Lee, In-A;Lee, Ji-Su;Baek, Seung-Hwa
    • Proceedings of the PSK Conference
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    • pp.139.2-140
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    • 2003
  • Tannin-rich fruit of Cornus officinalis Sieb. et Zucc has been used as an ingredient in several prescriptions of Oriental medicine. Cornis fructus was extracted by successive extraction. Cornis fructus extracts were investigated for antimicrobial and antioxidative activities. Antimicrobial effects used disk diffusion method. All extracts were examined against Streptococcus mutans. (omitted)

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Effect of caffeine on the antibacterial activity of Lactobacillus casei: caffeine and antibacterial activity of L. casei

  • Jang, Eunjeong;Park, Jin A;Kim, Young Ha;Kim, Ho
    • Korean Journal of Agricultural Science
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    • v.46 no.4
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    • pp.981-989
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    • 2019
  • Coffee is a popular beverage worldwide, and the scale of consumption is growing rapidly. Many studies have shown that increased coffee consumption has various effects on human health, including beneficial effects on liver diseases, clinical type 2 diabetes, and Parkinson's disease. However, the influences of coffee or caffeine (a component of coffee) on the gut microbiota have not been examined in detail. Here, we tested whether caffeine could alter the antimicrobial activity of L. casei against E. coli. Interestingly, we found that treatment with 0.3 mg/mL caffeine increased the antimicrobial activity of L. casei against E. coli. This activity was not associated with the release of lactic acid but did appear to be related to a heat-labile factor present in the L. casei culture supernatant. Our analyses suggest that the putative antimicrobial factor found in the culture supernatant of L. casei treated with caffeine may be bacteriocin. Taken together, our results suggest that caffeine, which is an ingredient of coffee, increases the antimicrobial activity of L. casei against E. coli through the enhanced production of bacteriocin. These findings also suggest that coffee consumption affects the ability of beneficial bacteria to decrease pathogenic bacteria and/or prevent the progression of bacterial infection-associated diseases in the gut.

Antimicrobial Effect of Puerariae thunbergiana Extracts against Oral Microorganism (칡 추출물의 구강미생물에 대한 항균효과)

  • Lee, Hyun-Ok;Kim, Chang-Hee;Lim, Jin-A;Lee, Mi-Hee;Baek, Seung-Hwa
    • Journal of dental hygiene science
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    • v.4 no.1
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    • pp.45-48
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    • 2004
  • In the current research for natural products with antimicrobial effects, various extracts of Puerariae thunbergiana and isoflavones against microorganisms were evaluated in terms of the minimum inhibitory concentrations (MIC). In general, Candida albicans was stronger antimicrobial activity than the other microorganisms such as Streptococcus mutans, Staphylococcus epidermidis, and Staphylococcus aureus. The maximum activity was exhibited by methanol extract of the leaves of Puerariae thunbergiana Beth. against Candida albicans(MIC, $400{\mu}g/mL$). These results suggest that methanol extract of Puerariae thunbergiana has a potential antimicrobial activity.

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Antimicrobial activities in the Korean Traditional Leaf Mustard, Brassica juncea Coss.

  • Kang Seong-Koo
    • Plant Resources
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    • v.8 no.2
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    • pp.96-102
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    • 2005
  • As part of developing natural food preservatives, the antimicrobial effect of ethanol and water extracts from the Cruciferous vegetable was examined Korean traditional Brassica juncea Coss. was used widely as an ingredient of Kimchi, a natural flavoring and spice for a long time. Antimicrobial activities were examined against 15 microorganisms which were food-born pathogens and/or food poisioning microorganisms and food-related bacteria and yeasts. Ethanol extract from leaf mustard showed an antimicrobial effect in most of the strains used in the present study. The lowest minimum inhibitory concentration (MIC) were seen in Bacillus subtilis and Bacillus natto at 10 mg/ml. MIC of water extract was 40-60 mg/ml for bacteria and yeast. Antimicrobial activity of the ethanol extract was not disappeared by the heating at $121^{\circ}C$ for 15 min and not affected by pH.

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Antimicrobial Peptides (AMPs) with Dual Mechanisms: Membrane Disruption and Apoptosis

  • Lee, Juneyoung;Lee, Dong Gun
    • Journal of Microbiology and Biotechnology
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    • v.25 no.6
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    • pp.759-764
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    • 2015
  • Antimicrobial peptides (AMPs) are one of the critical components in host innate immune responses to imbalanced and invading microbial pathogens. Although the antimicrobial activity and mechanism of action have been thoroughly investigated for decades, the exact biological properties of AMPs are still elusive. Most AMPs generally exert the antimicrobial effect by targeting the microbial membrane, such as barrel stave, toroidal, and carpet mechanisms. Thus, the mode of action in model membranes and the discrimination of AMPs to discrepant lipid compositions between mammalian cells and microbial pathogens (cell selectivity) have been studied intensively. However, the latest reports suggest that not only AMPs recently isolated but also well-known membrane-disruptive AMPs play a role in intracellular killing, such as apoptosis induction. In this mini-review, we will review some representative AMPs and their antimicrobial mechanisms and provide new insights into the dual mechanism of AMPs.