• Title, Summary, Keyword: plasma renin activity

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Factors Affecting the Relationship Between Renal Renin Activity and Plasma Renin Activity -I. Experiments in the Two Kidney one Clip Goldblatt Hypertensive Rats- (신장내(腎臟內) Renin Activity와 Plasma Renin Activity에 영향(影響)을 미치는 요인(要因) -I. 실험적(實驗的)인 신성고혈압(腎性高血壓)에 있어서의 영향-)

  • Cho, Kyung-W.;Kim, Sun-H.
    • The Korean journal of physiology & pharmacology
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    • v.16 no.1
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    • pp.63-68
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    • 1982
  • The change of plasma renin activity is one of the most important parameters explaining the pathological physiology of the hypertension. The relation between renal renin activity and plasma renin activity has not well been documented since last decades. In an attempt to clarify the relationship a series of experiments have been done in rats. The following results were observed. 1) Renal renin activity of clamped kidney increased after silver clipping and the increments were maintained until four to five weeks of operation. 2) Renal renin activity of the untouched contralateral kidney was vulnerable to be suppressed just after clamping, and the activity disappered almost below the limitation of the radioimmunoassay sensitivity up to four weeks. 3) Plasma lenin activity was changed by the renal renin activity, but the regression coefficient from the two kidney one clip Goldblatt hypertensive rats was different from the sham-operated, or age-matched control rats. 4) Plasma renin activity of all the groups tested has the exponential curve in terms of renal renin activity. These data suggest that the renal renin activity is important to control the plasma renin activity in certain experimental condition, especially in chronic status.

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Effect of Diuresis on Plasma Renin Activity and Aldosterone Concentration in Normal and Toxemic Pregnancy (정상임부와 임신중독환자의 혈장 Renin활성도 및 Aldosterone 농도에 미치는 이뇨의 효과)

  • Sung, H.K.;Lee, H.S.;Cho, S.S.;Koh, J.H.;Lee, J.K.;Kim, H.S.
    • The Korean Journal of Nuclear Medicine
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    • v.7 no.1
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    • pp.45-50
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    • 1973
  • The changes of plasma renin activity, aldosterone concentration, serum sodium-, and potassium levels were studied before and after the water loading followed by diuretics injection. The materials were: 13 non-, 11 normal-, and 11 toxemic pregnancy cases. The plasma renin activity and aldosterone concentration of the cord and postpartum blood were also measured. Following were the results: 1. The plasma renin activity was elevated significantly in normal pregnancy, and slightly in toxemic pregnancy. The serum sodium levels were decreased in pregnancy. 2. The plasma aldosterone concentration was slightly decreased in normal pregnancy, and slightly increased in toxemic pregnancy, however, statistically insignificant. 3. The plasma renin activity of the cord and postpartum blood were lower than those of pregnancy cases. 4. The changes of plasma renin activity after the diuretic administration showed an initial increase, which recovered within 2 hours. These changes were the least in normal pregnancy, and the most in toxemic pregnancy. 5. The changes of plasma aldosterone concentration after the diuretic administration were similar to those of plasma renin activity, although the variations were not so wide.

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Influence of Aging on Plasma Renin Activity (연령변동(年齡變動)에 따른 혈장(血漿) renin 활성(活性)의 변화(變化))

  • Cho, K.W.;Kim, S.H.;Kang, S.K.;Choi, H.Y.
    • The Korean Journal of Nuclear Medicine
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    • v.16 no.2
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    • pp.91-96
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    • 1982
  • Influence of aging on plasma renin activity was evaluated in healthy normotensive subjects (age range $21\sim63$ years, 413 males) devoid of cardiorenal or endocrinological problems. The age-related decrease of plasma renin activity in the subjects between $21\sim28$ years group and $36\sim42$ years group was slight, but over the 43 years groups was significantly different. The age-related suppression of plasma renin activity was much more smooth and continuous all over the age ranges evaluated. The sexual difference in plasma renin activity was noticed between the subjects of 22 years old group(34 males) and 19 years grop(34 females) (p<0.003). The data suggest that the age-related suppression of plasma renin activity appeared in healthy normotensive subjects should be considered in the case of evaluation of low renin essential hypertension.

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Characteristics of Control Mechanism of Renin-Angiotensin System in Two Kidney One Clip Goldblatt Hypertension (신성 고혈압 백서의 Renin Secretion 조절의 특성)

  • Jegal, Young-J.;Cho, Kyung-W.
    • The Korean journal of physiology & pharmacology
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    • v.20 no.1
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    • pp.89-102
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    • 1986
  • It has long been suggested that the change of renin-angiotensin system is responsible for the increased arterial blood pressure in the experimental hypertension. But the exact nature of the cause and maintenance of early and late Phase of renal hypertension is still controversial. Increased renin-angiotensin system has been suggested. To clarify the altered renin-angiotensin system in the early phase of two kidney one clip Goldblatt hypertension(2K1C GH), experiments were carried out in the rats of 3,7, and 14 days of 2K1C GH rats, sham-operated, and control rats. Responses of the plasma renin activity to the intravenous infusion of L-isoproterenol were dose-dependent. Responses of the plasma renin activity to the intravenous L-isoproterenol in 2K1C GH rats were not different from sham-operated control rats. Hypotensive responses of the 2K1C GH rats were not different from sham-operated rats. Suppression by intravenous infusion of angiotensin II of plasma renin activity showed a dose-dependent manner. Suppression by angiotensin ll of plasma renin activity was attenuated or abolished in the early phase of 2K1C GH rats. Intravenous infusion of arginine vasopressin(AVP) showed a dose-dependent suppression of plasma renin activity, Attenuated responses by AVP of plasma renin activity were noticed in the early phase of 2K1C GH rats. These results suggest that the altered renin-angiotensin system in the early phase of the two kidney one clip Goldblatt hypertension may be caused by failure of the short loop negative feedback control mechanism.

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Effects of Yukmijihwangtang Water Extracts on the Plasma Renin Activity, Plasma Levels of Aldosterone and Artrial Natriuretic Peptide in Rats (육미지황탕(六味地黃湯) 전탕액(煎湯液) 투여(投與)가 백서(白鼠)의 혈장(血漿) Renin 활성도(活性度), 혈장(血漿) Aldosterone 및 Atrial Natriuretic Peptide 농도(濃度)에 미치는 영향(影響))

  • Jeong, Weun-Kyung;Ryu, Do-Gon;Lee, Ho-Sub
    • The Journal of Korean Medicine
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    • v.18 no.2
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    • pp.267-272
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    • 1997
  • The aim of the present experiments was to investigate the effect of Yukmijihwangtang water extracts on the plasma renin activity and plasma levels of atrial natriuretic peptide and aldosterone in rats. The results of this study were as follows: 1. Plasma renin activity decreased significantly after the administration of Yukmijihwangtang water extracts 1.5ml/kg. 2. Plasma levels of atrial natriuretic peptide (ANP) decreased significantly after the administration of Yukmijihwangtang water extracts. 3. Plasma levels of aldosterone increased significantly after the administration of Yukmijihwangtang water extract.

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Effects of Yukmijihwangtang Water Extracts on the Plasma Renin Activity, Plasma Levels of Aldosterone and Artrial Natriuretic Peptide in Rats (육미지황탕(六味地黃湯) 전탕액(煎湯液) 투여(投與)가 백서(白鼠)의 혈장(血漿) Renin 활성도(活性度), 혈장(血漿) Aldosterone 및 Atrial Natriuretic Peptide 농도(濃度)에 미치는 영향(影響))

  • Jeong, Weun-Kyung;Ryu, Do-Gon;Lee, Ho-Sub
    • The Journal of Korean Medicine
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    • v.18 no.1
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    • pp.449-455
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    • 1997
  • The aim of the present experiments was to investigate the effect of Yukmijihwangtang water extracts on the plasma renin activity and plasma levels of atrial natriuretic peptide and aldosterone in rats. The results of this study were as follows: 1. Plasma renin activity decreased significantly after the administration of Yukmijihwangtang water extracts 1.5 ml/kg. 2. Plasma levels of atrial natriuretic peptide (ANP) decreased significantly after the administration of Yukmijihwangtang water extracts. 3. Plasma levels of aldosterone increased significantly after the administration of Yukmijihwangtang water extract.

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Some Aberrations of the Renin-Angiotensin System in Spontaneously Hypertensive Rat (Spontaneously Hypertensive Rat에 있어서 Renin-Angiotensin계의 변조에 관하여)

  • Chung, Sung K.;Cho, Kyung W.
    • The Korean journal of physiology & pharmacology
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    • v.19 no.2
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    • pp.189-202
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    • 1985
  • Enhanced activity of renin-angiotensin-aldosterone system has been suggested as a cause of the high blood pressure in certain forms of experimental hypertension. In spontaneously hypertensive rats, however, increased activity of the system has not been found, and even suppressed renin angiotensin system has been reported in the spontaneously hypertensive rat. In the present experiments it was attempted to explore the possible alteration of the short loop negative feedback control in the hypertensive rat. Experiments have been done in the anesthetized spontaneously hypertensive rats(SHR) as well as in normotensive Wistar and Sprague Dawley rats as control. Responses of the plasma renin activity to the intravenous L-isoproterenol were dose dependent, in both SHR and normotensive control rats. Hypotensive responses to smaller do sea of L-isoproterenol were more accentuated in SHR than in the normotensive control rats. Angiotensin If given intravenously suppressed plasma renin activity in a dose dependent fashion in both groups. However, these suppressive responses were significantly attenuated in SHR as compared with the normotensive control rats. Treatment with angiotensin I-converting enzyme inhibitor did not correct the attenuated responses of the plasma renin activity to angiotensin II in SHR. Intravenous infusion of arginine vasopressin also produced a dose-dependent suppression of plasma renin activity in both groups. The responses to arginine vasopressin were also significantly attenuated to the normotensive control rats. In the sodium-depleted SHR, arginine vasopressin did not suppress plasma renin activity, whereas the suppressive responses to arginine vasopressin in the normotensive control rats were not different from the untreated control rats. These data suggest that there may be a derangement in the short loop negative feedback control of the renin-angiotensin system in spontaneously hypertensive rat.

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Effects of Lycii Fructus Water Extracts on the Blood Pressure, Plasma Renin Activity and Plasma Levels of Atrial Natriuretic Peptide in Two-Kidney One Clip Goldblatt Hypertensive Rats (구기자(枸杞子) 전탕액(煎湯液)이 실험적(實驗的) 신성(腎性) 고혈압(高血壓) 백서(白鼠)의 혈압(血壓)과 혈장(血漿) Renin 활성도(活性度) 및 ANP 농도(濃度)에 미치는 영향(影響))

  • Lee, Ho-Su;Ryu, Do-Gon;Yun, Yong-Gap;Yu, Yun-Cho
    • The Journal of Korean Medicine
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    • v.17 no.1
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    • pp.37-46
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    • 1996
  • The aim of this experiments was to investigate the effect of Lycii Fructus water extracts on the blood pressure, plasma renin activity and plasma levels of atrial natriuretic peptide in two-kidney one clip Goldblatt hypertensive rats. Systolic blood pressure was decreased significantly after administration of Lycii Fructus water extracts. Plasma levels of atrial natriuretic peptide was increased significantly after adminstration of Lycii Fructus water extracts. Plasma renin activity was not changed after adminstration of Lycii Fructus water extracts. Thease results suggested that the depressor response after adminstration of Lycii Fructus water extracts were related with the changes of the plasma levels of atrial natriuretic peptide.

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Effects of Radix Aconiti Water Extract on the Plasma Renal Activity and Plasma Levels of Aldosterone and Atrial Natriuretic Peptide in the Rats (부자(附子) 전탕액(煎湯液) 투여(投與)가 백서(白鼠)의 혈장(血漿) Renin 활성도(活性度), 혈장(血漿) Aldosterone 및 Atrial Natriuretic Peptide 농도(濃度)에 미치는 영향(影響))

  • Lee, Ho-Sub;Yu, Yun-Cho
    • The Journal of Korean Medicine
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    • v.17 no.2
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    • pp.291-295
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    • 1996
  • The aim of this experiments was to investigate the effecd of Radix Aconiti water extrac on the plasma renin activity and plasma levels of aldosterone and atrial natriuretic peptide in rats. The results of study were as follows; Plasma renin activity was decreased significantly after administration of Radix Aconiti water extract. Plasma levels of aldosterone was decreased significantly after administration of Radix Aconiti water extract. Plasma levels of atrial natriuretic peptide was not changed after administration of Radix Aconiti water extract.

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ARC availability experiment by comparing plasma renin activity (PRA) and active renin concentration (ARC) (Plasma renin activity(PRA) and Active renin concentration(ARC)비교를 통한 ARC 유용성 실험)

  • Park, Jun Mo;Kim, Han Chul;Choi, Seung Won
    • The Korean Journal of Nuclear Medicine Technology
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    • v.22 no.1
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    • pp.84-89
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    • 2018
  • Purpose Renin is a proteolytic enzyme synthesized and secreted from epidermal(juxtaglomerular) cells in kidney. Renin acts on the renin substrate angiotensinogen to produce angiotensin I, and then angiotensin II is produced by the action of angiotensin converting enzyme. This causes the adrenal glands to boost blood pressure (vasoconstriction) and promote aldosterone secretion. While Plasma renin activity (PRA) is to test angiotensin I, the active renin concentration (ARC) is a renin test directly. They have different test methods and their own substrates. However, these two methods are sometimes interpreted as the same as a result. The purpose of this study was to evaluate the usefulness of the ARC test by comparing the results between PRA and ARC. Materials and Methods For the diversity of the experiment, 26 samples were requested to test with PRA(TFB company) and ARC(Cisbio company) to other institution. We compared and analyzed PRA(Immunotech company) and ARC(Cisbio company) tests using 28 samples from September $15^{th}$ to October $13^{th}$ in 2017. The statistical analysis method for PRA/ARC evaluated the usefulness using Microsoft Excel program by verifying a correlation analysis of Aldosterone/PRA ratio and a correlation analysis of Aldosterone/ARC ratio and conducting T-test. Results The regression equation of the PRA(Immunotech company)/ARC(Cisbio company), which was tested in the department, was y = 0.0619x + 0.4615 and the correlation coefficient was 0.73. The regression equation of the PRA(TFB company)/ARC(Cisbio company), which was tested in the other institution, was y = 0.0888x + 0.3316 and the correlation coefficient was 0.91. In addition, The regression equation of Aldosterone / PRA ratio and Aldosterone / ARC ratio was y = 0.875x - 11.688 and the correlation coefficient was 0.87. Plus T - test showed no significant difference (P>0.05). Conclusion Both tests showed a strong positive correlation, but this only represents the strength and direction of the relationship between the two tests. Furthermore, the actual results showed somewhat differences. It is presumed that the measured value was influenced by the endogenous renin group mass in the plasma, the condition of the enzyme reaction and the kind of the inhibitor. When the active renin concentration (ARC) test is performed, it is useful to distinguish between the two tests as they are complementary.