• Title, Summary, Keyword: pressure sensitive adhesive

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Effect of Enhancers and Pressure Sensitive Adhesives on the Transdermal Delivery of Fentanyl

  • Lee, Ji-Young;Jang, Joon-Ho;Choi, Hoo-Kyun
    • Journal of Pharmaceutical Investigation
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    • v.38 no.4
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    • pp.223-228
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    • 2008
  • The purpose of this study was to investigate the feasibility of developing transdermal drug delivery system (TDDS) for fentanyl used for the management of chronic cancer pain. The effect of type of pressure sensitive adhesive on the permeation of fentanyl from polyisobutylene (PIB), silicone and acrylic adhesive was evaluated. Due to the good adhesive force and relatively steady flux for 3 days, both acrylic and PIB adhesives were chosen for further study. The permeation rate of fentanyl was the highest from acrylic adhesive with hydroxyl functional group. Permeation rate increased linearly as the concentration of fentanyl in acrylic adhesive was increased from 2.5% to 10%. In case of PIB adhesive, crystals of fentanyl were developed above 5% drug load. $Crovol^{(R)}$ A40, $Crovol^{(R)}$ PK40 and Plurol $oleique^{(R)}$ provided higher flux of fentanyl.

Transdermal Delivery of Estradiol and Norethindrone Acetate: Effect of Vehicles and Pressure Sensitive Adhesive Matrix

  • Chun, Myung-Kwan;Choi, Hoo-Kyun
    • Journal of Pharmaceutical Investigation
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    • v.35 no.3
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    • pp.173-177
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    • 2005
  • Addition of 30% propylene glycol was required to maintain sink condition in the evaluation of percutaneous absorption of estradiol and norethindrone acetate. The permeability of estradiol was higher in silicone and SIS adhesives. However, estradiol was crystallized in silicone, SIS, and SBS adhesive matrix. The permeability ratio of estradiol or norethindrone acetate from acrylic pressure sensitive adhesives varied widely depending on the functional group of the acrylic adhesives. PEO grafting to acrylic adhesive seemed to change physicochemical property of acrylic adhesive and increased the permeability of estradiol and norethindrone acetate significantly. On the contrary, highly cross-linked enhancer compatible acrylic adhesive decreased the permeability of both estradiol and norethindrone acetate. $Span^{\circledR}$ 20 provided the highest enhancing effect on the permeability of both estradiol and norethindrone acetate followed by oleic acid and $Crovol^{\circledR}$ EP40. The permeability of the drugs from the developed system was comparable to that from commercial $Combitran^{\circledR}$, although significantly lower amount of estradiol and norethindrone acetate were loaded in the developed system.

The Development of UV Blocking Type Pressure-Sensitive Adhesive Sheet for Window (자외선이 차단되는 창문용 점착시트 개발에 관한 연구)

  • Kim, Sung-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.12 no.1
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    • pp.559-564
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    • 2011
  • The UV blocking type pressure-sensitive adhesive sheet was developed by mixing UV blocking reagent with adhesive material, instead of conventional method in which the reagent was mixed with PVC substrate. The blocking performance of the sheet was evaluated by measuring the absorbance in 280-400 nm region. Both organic and inorganic type blocking reagents were examined. The blocking ability of the former is better than that of the later. Only 1% addition of blocking reagents is effective to block UV light without affecting to visibility and tackiness of adhesive tapes.

A Study on Synthesis of Acrylic Pressure Sensitive Adhesive for Polarizer Film by Solution Polymerization (용액중합에 의한 편광필름용 아크릴 점착제의 합성에 관한 연구)

  • Lim, Chang-Hyuk;Jung, Young-Jae;Cho, Ur-Ryong
    • Elastomers and Composites
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    • v.44 no.2
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    • pp.175-181
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    • 2009
  • The solution polymerization was conducted to synthesize pressure sensitive adhesive for polarizer film using acrylic monomers. 2-Ethylhexyl acrylate, butyl acrylate, acrylic acid were used as acrylic monomers, benzoyl peroxide as initiator, ethyl acetate as solvent. The ratio of monomers was 2-ethylhexyl acrylate: butyl acrylate: acrylic acid = 25:50:3.6 reflecting $-40^{\circ}C$ of glass transition temperature in the pressure sensitive adhesive. The amount of initiator was determined as 0.09% to monomer considering wetting power and initial tackiness. The ratio of monomer to solvent was determined as 1:1.7 considering wetting power and transmissivity. The transmissivity of pressure sensitive adhesive increased with decreasing both viscosity and molecular weight due to reducing of refractive index by low entanglement between molecules. In the measurement of pot life, it was found that the storage stability was good at 1:1.7 of monomer: solvent without large change of viscosity during 200 min.

The Effects of Coupling Agent and Crosslinking Agent in the Synthesis of Acrylic Pressure Sensitive Adhesive for Polarizer Film (편광필름용 아크릴 점착제의 합성에서 커플링제와 가교제의 효과)

  • Lim, Chang-Hyuk;Ryu, Hoon;Cho, Ur-Ryong
    • Polymer(Korea)
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    • v.33 no.4
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    • pp.319-325
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    • 2009
  • The solution polymerization was conducted to synthesize pressure sensitive adhesive for polarizer film using acrylic monomers. 2-Ethylhexylacrylate, butylacrylate, acrylic acid were used as acrylic monomers. The ratio was 2-ethylliexylacrylate:butylacrylate:acrylic acid=25:50:3.6 by reflecting $-40^{\circ}C$ of glass transition temperature in the pressure sensitive adhesive. When 1 wt% of coupling agent was added to the polymerized pressure sensitive adhesive, the light transmissivity was significantly increased. This result is due to the enhancement of adhesive power against liquid crystal cell by Si-O bond of coupling agents. Cross-linking agent was added by 0.5, 1.0, and 1.5 wt% with respect to the synthesized polymer. Initial tackiness decreased, while cohesion increased with increasing crosslinking agent. In the analysis of contact angle, the increase of crosslinking agents yielded the enhancement of surface energy, resulting in the decrease of contact angle. From the measurement of heat resistance, the acrylic pressure sensitive adhesive showed excellent heat resistance regardless of change in temperature and contents in crosslinking agent. In the observation of a cutting plane, the increased crosslinking agent represented a smoother and cleaner section. Comprehensively, the optimum additive amount of crosslinking agent was determined to be 1.0 wt% to monomer.

Preparation of Pressure Sensitive Adhesive Using Reactive Polyurethane Resin and the Effect of Interfacial Crosslinking on the Adhesion Property (반응성 폴리우레탄 레진을 이용한 Pressure Sensitive Adhesive 제조 및 계면 가교 반응이 점착 물성에 미치는 영향)

  • Shin, Jin Sup;Kim, Ji Heon;Cheong, In Woo;Kim, Jung Hyun
    • Applied Chemistry for Engineering
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    • v.16 no.1
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    • pp.81-85
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    • 2005
  • Pressure sensitive adhesive (PSA) was prepared by semi-batch emulsion polymerization of acryl monomers in the presence of reactive and non-reactive carboxylated polyurethane resin (PUR). Effects of the PUR type, its content, and crosslinker feeding method on the adhesive properties of the PSA was investigated. In this experiment, the PSA prepared with the reactive PUR showed better adhesive property then the PSA with the non-reactive PUR. Especially, peel strength of the PSA, where acetoacetoxy ethyl methacrylate and 1,6-hexane diamine as crosslinkers were introduced, was dramatically enhanced in severe humidity condition due to the interfacial crosslinking.

A Study on Thermal Conductive Acrylic Pressure Sensitive Adhesive with Alumina and Graphite (알루미나와 흑연을 포함하는 열전도성 아크릴 점착제의 연구)

  • Oh, Ji Hwan;Jang, Sun Ho;Yoo, Seong Sik;Cho, Ryong
    • Journal of the Semiconductor & Display Technology
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    • v.16 no.3
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    • pp.93-98
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    • 2017
  • 2-Ethylhexyl acrylate, butyl acrylate, methyl methacrylate, and 2-hydroxyethyl methacrylate were polymerized to synthesize acrylic pressure sensitive adhesive (PSA). Alumina and graphite as a filler were added to acrylic PSA to give thermal conductivity. In case of addition of both graphite and alumina, the thermal conductivity of PSA was increased compared with alumina alone due to enhancement of contact between two fillers followed by increasing thermal path in PSA matrix.

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