• Title, Summary, Keyword: productivity of IL-2

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The Study on Acute and Subacute Toxicity and Sarcoma-180 Anti-cancer Effects of Vermilionum (영사(靈砂)의 급성(急性).아급성(亞急性) 독성(毒性) 및 Sarcoma-180 항암효과(抗癌效果)에 관(關)한 문헌적(文獻的) 연구(硏究))

  • Kwon, Ki-Rok
    • Journal of Pharmacopuncture
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    • v.6 no.3
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    • pp.39-47
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    • 2003
  • Background & Methods : In order to measure the acute and subacute toxicity of Vermilionum and it's anti-cancer effects, Sarcoma-180 abdominal cancer cells were injected intravenously. The following results were obtained after measuring the survival rate, toxicity of the NK cells, and IL- 2 productivity. Results : 1. It was impossible to measure $LD_{50}$ value in the acute toxicity test and no toxic effects were witnessed in the clinical observation. 2. No significant differences were shown in the weight changes between the experiment groups and the control group in the acute toxicity test. 3. No peculiar toxic effects were shown in the subacute toxicity test and the weight changes were insignificant between the experiment groups and the control group. 4. In measuring the survival rate after inducing abdominal cancer by Sarcoma-180, the experiment groups showed increased of 9.52% compared to the control group. 5. In measuring the activity of NK cells, no significant changes were shown between the experiment groups and the control group. 6. In measuring the productivity of IL-2, significant reduction was shown in the experiment groups compared to the normal group, but no significance was witnessed compared to the control group.

Anticancer and Immune Effects of Chungpae-tang on the Metastasis of Lung Cancer Cell (청폐탕(淸肺湯)의 실험적 폐전이암에 대한 항암 및 면역효과에 관한 연구)

  • Lee Dong-Ju;Kim Myung-Dong;Kim Young-Sam;Yoo Yeong-Min;Lee Seon-Goo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.19 no.5
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    • pp.1281-1291
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    • 2005
  • Chungpae-tang is suggested to have the antitumor activity on lung cancer. This study was peformed to investigate apoptotic effect in vitro and antitumor effect and immune response after injection of B16-F10 melanoma cells and Chungpae-tang into a tail vein of C57BL/6 mice and administratition of Chungpae-tang in A549 human lung cancer cell line in vivo, respectively. Experimental studies were obtained by measuring the median survival time and cytokine expression through RT-PCR, and ELISA assay. The results were summarized as follows: 5 mg/ml of Chungpae-tang causing DNA fragmentation, caspase-3 enzyme activation, PARP fragmentation, and cytochrome c release, suggested that Chungpae-tang has in vitro apoptotic effect in A549 human lung cancer cell line in the apoptosis-induced experiment. The median survival time of the Chungpae-tang treated group was 21 days and that of control group was 22 days, suggesting that the median survival time between the Chungpae-tang treated group and the control group was not significant. Cytokine expression between the Chungpae-fang treated group and the control group was noticeable, but was not significant in the RT-PCR. In the ELISA assay, IL-2 productivity in the Chungpae-tang treated group was to increase more than that in the normal group (p<0.05) and was no significant between the Chungpae-tang treated group and the control group. $INF-\gamma$ productivity of the control group decreased more than that of the normal group (p<0.05) and that of the Chungpae-tang-treated group increased more than that of the control group (p<0.05). IL-12 productivity of the control group increased more than that of the normal group (p<0.05) and that of the Chungpae-tang-treated group decreased more than that of the control group (p<0.05) and the normal group. IL-4 productivity of the Chungpae-tang-treated group increased more than that of the normal group and the control group (p<0.05). IL-10 productivity of the Chungpae-tang-treated group increased more than that of the normal group and the control group (p<0.05). Accordingly the results show Chungpae-tang could induce apoptosis in A549 human lung cancer cell line and bring to antitumor effect and immune response against injection of B16-F10 melanoma cells into a tail vein of C57BL/6 mice but it needs more research on the precise mechanism of such effects.

An Experimental Study on Effects of Distilled Red-ginseng Herbal Acupuncture on A549 human ephithelial lung cancer cell in vitro and implanted Sarcoma-180 (A549 폐암세포와 Sarcoma-180 복강암에 대한 홍삼(紅蔘) 증류약침(蒸溜藥鍼)의 영향에 관(關)한 실험적(寶驗的) 연구(硏究))

  • Won, Seung-Hwan;Kwon, Ki-Rok;Lee, Sun-Gu
    • Journal of Pharmacopuncture
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    • v.7 no.2
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    • pp.43-56
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    • 2004
  • Objectives : In order to investigate effects and immune improvement of distilled red-ginseng herbal Acupuncture, expression of Cox-1, Cox-2, and mRNA of Bcl-2 and Bax were analyzed in A549 cell in vivo. Survival time and expression of cytokine mRNA were measured for the mice with Sarcoma-180 induced abdominal cancer. Methods : Balb/c mouse was treated with distilled red-ginseng Herbal Acupuncture at Wisu($BL_{21}$) and Chung- wan($CV_{12}$) to investigate anti-cancer effects and immune response. Results : 1. For expression of mRNA of Cox-1 using RT-PCR, the control group and the experiment groups didn't show significant differences. For Cox-2, both experiment groups and the normal group showed significant differences. 2. For expression of mRNA of Bcl-2 using RT-PCR, experiment groups showed slight decrease compared to the control group. For Bax, no significant changes were shown between the control group and experiment groups. 3. For survival time, all of experiment groups showed 11.1% increase compared to the control group. 4. For IL-2 and IL-4 productivity using Flow cytometry, all of experiment groups didn't show any significance. 5. For IL-2 productivity using ELISA, all of experiment groups didn't show any significance. 6. For expression of cytokine mRNA using RT-PCR, significant increase of IL.-2 and IL-4 were witnessed in the experiment group II compared to the control group. Significant increase of IL-10 was shown in all off experiment groups compared to the control group. Conclusion : According to the results, we can expect that distilled red-ginseng Herbal Acupuncture may be further effccts in anti-cancer and immune improvement if increasing concentration.

A Case Study of SW Development Productivity Improvement by MDD/MDA Technology Application in CBD Project (CBD 프로젝트에서의 MDD/MDA 기술 적용을 통한 개발생산성 향상 사례)

  • Choi, Jeong-Il
    • Journal of Information Technology Services
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    • v.5 no.2
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    • pp.179-188
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    • 2006
  • MDD/MDA which recently raising its head is technology that increase software development productivity through automatic transformation form higer abstract model into lower abstract model, or from model to code. This paper analyzes the effect on productivity by measuring Function Point per MM(man-month) in a software development project which performed in CBD methodology, and introduce the method of applying MDD/MDA technology in the project.

The ecosystem modelling for enhancement of primary productivity in Kamak Bay (가모만에서의 기초생산력 향상방안에 관한 생태계모델링)

  • Lee, Dae-In;Jo, Eun-Il;Park, Cheong-Gil
    • Journal of Environmental Science International
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    • v.8 no.5
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    • pp.575-586
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    • 1999
  • From the environmental aspects, primary productivity of phytoplankton plays the most improtant role in enhancement of marine culture oyster production. This study may be divided into two branches; one is estimation of maximum oyster meat production per unit facility(Carrying Capacity) under the present enviromental conditions in Kamak Bay, the other is improvement of carrying from increase of primary productivity by changing the environmental conditions that cause not ot form an unfavorable environment such as the formation of oxygen deficient water mass using the eco-hydrodynamic model. By simulation of three-dimensional hydrdynamic model and ecosystem model, the comparison between observed and computed data showed good agreement. The results of sensitivity analysis showed that phytoplankton maximum growth rate was the most important parameter for phytoplankton and dissolved oxygen. The estimation of mean primary productivity of Wonpo, Kamak, Pyongsa, and Kunnae culture grounds in Kamak Bay during culturing period were 3.73gC/$m^2$/d, 2.12gC/$m^2$/d, 1.98gC/$m^2$/d, and 1.26gC/$m^2$/d, respectively. Under condition not ot form the oxygen deficient water mass, four times increasing of pollutants loading as much as the present loading from river increased mean primary productivity of whole culture grounds to 4.02gC/$m^2$/d. Sediment N, P fluxes that allowed for 35% increasing from the present conditions increased mean primary productivity of whole culture grounds to 3.65gC/$m^2$/d. Finally, ten times increasing of boundary loadings from the present conditions increased mean primary productivity of whole culture grounds to 3.95gC/$m^2$/d. The maximum oyster meat production per year and that of unit facility in actual oyster culture grounds under the present conditions were 6,929ton and 0.93ton, respectively. This 0.93ton/unit facility is considered to be the carrying capacity in study area, and if the primary productivity is increased by changing the environmental conditions, oyster production can be increased.

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Numerical Simulation of water quality by ${\Delta}COD$ method for Inner Productivity Estimation of Yeong-Il Bay (간이변환 수질예측모델에 의한 영일만 내부생산성 평가)

  • Yoon, Han-Sam;Ryu, Cheong-Ro;Lee, In-Cheol;Kim, Heon-Tae
    • Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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    • pp.99-104
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    • 2003
  • This study investigated the yearly variation of pollutant loads outflowing from six watershed of Yeong-il Bay and compared the relationship of pollutant load and water quality, and estimated the Inner productivity of Yeong-Il Bay by using ${\Delta}COD$ method which analysis nonlinear process of water quality. As the estimated results for the pollutant loads of Yeong-Il Bay, total COD load outflowing from Hyeong-san river in flood season(summer) of 2001 year was 2275.0 kg/hr and in dry(low water) season(winter) 852.8 kg/hr, respectively. Load quantity in flood season was about 2.67 times than that in dry season. And as the calculated results of the net-flux of water for seven divisions, it showed that the net-flux of water increased for the divisions of the north coast and inner sea of Yeong-Il Bay but decreased for the south coast. On the contrary, for the cases which water quantity increase from land, the net-flux of water in estuary front of Hyeong-san river decreased but outflowing quantity of that though division of the south coast of Homi-got increased. Finally, this study compared the Inner productions for flood and dry season of Yeong-il Bay by using ${\Delta}COD$ method.

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Vertical Distribution of Biogenic Elements and its Implication on Holocene Paleoclimatic Records in the Maxwell Bay of the South Shetland Islands, West Antarctica

  • Kim, Dong-Seon;Park, Byong-Kwon;Yoon, Ho-Il
    • Journal of the korean society of oceanography
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    • v.32 no.2
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    • pp.69-74
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    • 1997
  • Depth profiles of organic carbon (C), biogenic silica (Si), and inorganic phosphorus (P) in Maxwell bay sediments were determined to investigate paleoclimatic changes during Holocene. Organic C and biogenic Si contents generally show a down-core decrease trend, which appears to be mostly controlled by their vertical fluxes through productivity in the surface waters, but it is uncertain that inorganic P contents are directly influenced by productivity changes with time. Before 4000 yr B.p. marine productivity seemed to be almost zero because ice permanently covered the surface waters of the study area. As the climate started to become relatively warm at 4000 yr B.p., ice was sporadically melted in the surface waters and thereby marine productivity gradually increased until 1500 yr B.p. For the last 1500 year, marine productivity must be high enough to overcome the dilution by high terrigenous sedimentation, thus that period was the warmest during the last 6000 year.

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A study on the Productivity Management System of small and medium sized companies (중소기업의 생산성 경영시스템에 관한 연구)

  • Kim, Sok-Eun;Oh, Seon-Il;Kang, Kyung-Sik
    • Journal of the Korea Safety Management and Science
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    • v.10 no.3
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    • pp.155-166
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    • 2008
  • Advanced countries worldwide lead government leading management innovation by suggesting unique managing system which can be survived in global economy war including JQA of Japan and EFQM of Europe based basically on MBNQA of U.S.A. and by rewarding to suitable companies. Mckinsey, global management and consulting company points out that Korea has no management because Korean productivity level which dependence to small and medium sized companies is high by the limitation of elemental invests leading type growth strategy including labor and capital is only 1/2 of U.S.A. and 2/3 of Japan. In particular, the competitive power of Korean small and medium sized companies goes into a recession by productivity lowering according to the chinese follow-up, laboring time shortening, variety and aging, and fundamental management innovation activities for reinforcing survival and competitive power are needed. Therefore, in this study, we try to construct the model of productivity managing system of innovation type small and medium sized companies which make excellent results.

A Study on the relations between change of productivity and conversion factor of the Accredited Hospitals based on Malmquist index (Malmquist 지수에 기초한 의료기관평가 대상 병원의 생산성 변동과 환산지수 변동에 관한 연구)

  • O, Dong-Il
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.12 no.1
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    • pp.125-137
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    • 2011
  • This study aims to know whether the Accreditation of Hospitals can help to improve productivity of hospital and affect the conversion factor. Based on the Malmquist productivity Index, the productivity of accredited hospital improves. There exists an tendency that as the scores of Accreditation rises, productivity increases. Also the higher the productivity, the lower the conversion factors in the rigid statistical evidence. This evidence is independent of hospital classification, geographical distribution, grouping. This evidence supports the productivity index can be included in the fee negotiations. It also means that rather than static efficiency, the multi-year change of productivity information can be usefully combined to set a conversion factor in Korean National Insurance Contract especially in the discussion of the structural change of payment system.