• Title, Summary, Keyword: pustular

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A Case of Subcorneal Pustular Dermatitis treated with Oriental Medicine (각질하 농포성 피부병 한방 치험 1례)

  • Kim, Min-Hee;Yun, Young-Hee;Yu, Seung-Min;Choi, In-Hwa
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.24 no.2
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    • pp.87-95
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    • 2011
  • Objective : Subcorneal pustular dermatosis is a rare, chronic neutrophilic dermatoses that was first described in 1956. The eruption is characterized by flaccid pustules grouped in a circinate pattern on normal or erythematous skin. We treated a case of subcorneal pustular dermatosis in one patient; there have been no former reports of this disease treated by oriental medicine. We present this case because we considered it to be useful as a possible Oriental medicine treatment for subcorneal pustular dermatosis, and something that canbe used for further study of neutrophilic dermatoses. Method : We used herbal medication, acupuncture, herbal wet dressing, herbal ointment, cupping therapy and phototherapy during treatment. We assessed symptoms during treatment and also carried out blood tests through out. Result : We observed and treated a case of subcorneal pustular dermatosis patient and after treatment the patient's objective and subjective symptoms showed noticeable improvement. Conclusion : We suggest that subcorneal pustualr dermatosis can be treated by Oriental medicine therapy effectively. We expect these study results will help provide useful evidence of Oriental medicine as an effective treatment for subcorneal pustualr dermatosis.

Subcorneal pustular dermatosis in a dog (개에서 발생한 각질하 농포성 피부병 1례)

  • Park, Seong-Jun
    • Korean Journal of Veterinary Research
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    • v.53 no.2
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    • pp.125-127
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    • 2013
  • Canine Subcorneal pustular dermatosis (CSPD) represents a sterile, superficial, pustular skin disease of unknown cause but may be a variant of pemphigus foliaceus. A 7-year-old, intact female, mixed dog presented with 3-month history of pruritic multiple pustules and crusts. Direct smears from intact pustules revealed numerous nondegenerate neutrophils, some acantholytic cells, and bacterial culture was negative. Histologic examination of lesional skin showed subcorneal pustules filled with neutrophils and acantholytic cells. The direct immunofluorescence tests stained with IgG, IgA, IgM, C3 were negative. Oral administration of dapsone (1 mg/kg/q8h) was initiated and it was reduced to 1 mg/kg/q12h with good control of the lesions.

Subcorneal Pustular Dermatosis Successfully Treated with Acitretin in a Dog

  • Cho, Daehee;Cho, Nayoung;Park, Jungho;Lee, Wanghui;Park, Seongjun
    • Journal of Veterinary Clinics
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    • v.37 no.6
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    • pp.339-341
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    • 2020
  • Subcorneal pustular dermatosis (SPD) is a rare pustular skin disorder of dogs. Dapsone is treatment of choice, but ineffective in some cases. Therapeutic alternatives are limited and less effective. In humans, successful results with oral retinoid have been reported. To describe successful treatment of a dog that developed SPD with acitretin as an alternative drug of dapsone. A 7-year-old male neutered miniature schnauzer was presented with generalized pustules and crusts. SPD was diagnosed based on physical, cytological, and histopathological examination with direct immunofluorescence test. In this report, we describe a case of canine SPD treated initially by dapsone with poor response that improved with acitretin. Acitretin could be considered as an alternative drug in canine SPD.

A Case of Paradoxical Flare of Pustular Psoriasis after Ustekinumab Therapy (Ustekinumab 치료 후 발생한 고름물집건선의 Paradoxical Flare 1예)

  • Kang, In-Hye;Shin, Min Kyung;Lee, Mu-Hyoung;Jeong, Ki-Heon
    • Korean journal of dermatology
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    • v.56 no.9
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    • pp.548-551
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    • 2018
  • Biologics are the most advanced treatment for psoriasis. Ustekinumab, one of the biologics for psoriasis, is a human monoclonal antibody that binds to the p40 subunit of interleukin-12 and interleukin-23. A 41-year-old woman with a 17-year history of plaque psoriasis and psoriatic arthritis presented with worsening lesions. The patient had previously been treated with a number of topical and systemic medications and narrow band ultraviolet B. However, none of the treatments consistently controlled her disease. Thus, treatment with ustekinumab 45 mg via subcutaneous injection was initiated. Approximately 7 days after the first treatment, she experienced a flare with generalized pustules in her whole body. The condition was controlled with systemic steroid treatment. The patient was subsequently treated with adalimumab, and improvement in her plaque and pustular lesions was noted. Herein, we report a case of psoriasis that flared up after ustekinumab therapy, which was accompanied by a morphological change from plaque to pustular lesions.

A Case of Localized Pustular Psoriasis (국소성 농포성 건선 치험 1례)

  • Choi, Joon-Gi;Choi, Eun-Hee;Kim, Kung-Joon;Park, Min-Cheul
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.19 no.2
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    • pp.313-319
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    • 2006
  • Background and Objective : Localized Pustular Psoriasis(LPP) is a rare form of psoriasis characterized by erythematous papules, plaques studded with pustules(usually on palms or soles) However, the pathophysiology of the LPP remains obscure. Treatment at present is symptomatic and supportive. There is no report on LPP treated with oriental medical treatment. Methods : We conducted one patient with LPP seen at Won-Kwang University Ik-San Oriental Medical Hospital in 2003. We treated LPP in a forty-nine years old man by a herbal medicine, acupuncture, moxa, etc Conclusions : We had a significant results. So we report this case to estimate the efficiency of oriental medic at treatment and management on LPP

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Porcine juvenile pustular psoriasiform dermatitis in Korea (자돈 농포성 건선양 피부염 증례 보고)

  • Yoon, Soon-Seek;Lee, Kyeong-Hyun;Bae, You-Chan;Moon, Oun-Kyong;Kwon, Yong-Kuk;Han, Hong-Ryul
    • Korean Journal of Veterinary Research
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    • v.45 no.3
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    • pp.375-379
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    • 2005
  • Porcine juvenile pustular psoriasiform dermatitis (PJPPD) is a disease of young pigs and characterized by nonpruritic round eruption of skin. The cause of this disease is yet undetermined but is presumed to be genetic predisposition. There may be few opportunities for veterinarian to detect this disease compared with actual situation in field because these lesions resolve spontaneously in two months. The authors detected spontaneous PJPPD case and performed clinical and pathological studies on three pigs from one farm. The specific skin lesions were observed in the forty-day old pigs of mixed breed, which were produced by the sows received semen from the same boar, restrictively. However, there was no skin lesion of pigs in suckling or fattening periods. Grossly, lesions were commonly found on the ventral abdominal part as a papule and were spreaded to the skin of whole body. With the spreading of lesions centrifugally, skin was showed as a umbilicated plaques or mosaic pattern with a few pustules or crusts. Microscopically, the most prominent lesion was the psoriasiform hyperplasia with acanthosis, down growth of rete ridges, exocytosis of eosinophils and neutrophils, ballooning degeneration of superficial epidermis, and koilocytic degeneration of keratinocytes. Additionally, there were moderate dermal edema and severe mixed cellular infiltration, especially eosinophils. No infectious agent which can cause the skin lesion, was detected or cultured, and no lesion caused by infectious agents was also observed, pathologically. With pathological results of this study, it is supposed that pathogenesis or severity of PJPPD may be related to the infiltration of eosinophil or hypersensitivity.

Clinical investigations of canine superficial pyoderma (개에서 표재성 세균성 피부염에 관한 임상적 고찰)

  • Oh, Tae-ho
    • Korean Journal of Veterinary Research
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    • v.39 no.5
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    • pp.1017-1020
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    • 1999
  • Fifteen dogs with superficial pyoderma were investigated clinically. Dermatological signs were mainly consisted of papule (66.6%), pustule (86.6%), epidermal collrarette and patchy (40%), and hyperpigmentation (53.3%). Distribution of skin lesion were consisted of back (35.5%), abdomen (29.0%), axillary (6.4%), leg (3.2%), neck (3.6%) and foot (16.1%), respectively. In pustular cytology PMN cells and cocci were examined. Cephalexin was very effective antibiotics on superficial pyoderma at administration of 30mg/kg bid P.O. for 3 weeks. Hyperadrenocorticism and atopy were diagnosed as a primary cause on pyoderma in 2 dogs.

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Neonatal skin diseases (신생아 피부질환)

  • Kim, Kyu Han
    • Clinical and Experimental Pediatrics
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    • v.49 no.1
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    • pp.1-5
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    • 2006
  • Several physiological skin changes such as vernix caseosa, cutis marmorata, physiologic desquamation, and sebaceous hyperplasia have been described in the neonatal period. There are also clinical characteristics of skin peculiar to neonate and infancy. Skin disorders observed during neonatal and infancy period can be divided into transient skin lesions, birth marks, and other diseases. Transient skin lesions include milia, sebaceous gland hyperplasia, erythema neonatorum, transient neonatal pustular melanosis, and acne neonatorum. Nevocellular nevus, mongolian spot, vascular malformation, hemangioma, epidermal nevus, and sebaceous nevus belong to birth marks. There are several common skin diseases such as miliaria, diaper dermatitis, atopic dermatitis, seborrheic dermatitis, and cutaneous candidiasis.