• Title, Summary, Keyword: pyrantel pamoate

Search Result 16, Processing Time 0.035 seconds

The anti-parasitic efficacy of ivermectin and pyrantel pamoate compound against canine Toxocara canis and Trichuris vulpis

  • Youn, Heejeong;Ra, Jeong Chan;Kim, Byung Ki;Bae, Bokyoung;Lim, Yong Suk;Kim, Kyong Hee;Lee, Kyong-Eun
    • Korean Journal of Veterinary Research
    • /
    • v.51 no.4
    • /
    • pp.289-295
    • /
    • 2011
  • Toxocara (T.) canis and Trichuris (T.) vulpis are very important canine parasitic nematodes. T. canis parasitize in small intestine and T. vulpis parasitize in large intestine. In order to control of these nematodes, ivermectin and pyrantel pamoate compound was applied to the dogs infected with these parasites naturally and artificially. This drug was composed of $68.0{\mu}g$ of ivermectin and 57.0 mg of pyrantel pamoate for small animal, $136.0{\mu}g$ of ivermectin and 114.0 mg of pyrantel pamoate for middle animal, and $272.0{\mu}g$ of ivermectin and 227.0 mg of pyrantel pamoate for large animal. Ivermectin in this drug is activity to nematodes and ectoparisites. Pyrantel pamoate in this drug is also activity to nematodes. In this experiment, this drug had a good efficacy against T. canis and T. vulpis in the infected dogs.

Studies on the anti-parasitic efficacy and safety of ivermectin and pyrantel pamoate compound against Dirofilaria immitis in dogs

  • Youn, Heejeong;Ra, Jeong-Chan;Kim, Byung-Ki;Lim, Yong-Suk;Kim, Kyong-Hee;Lee, Kyong-Eun
    • Korean Journal of Veterinary Research
    • /
    • v.52 no.1
    • /
    • pp.53-56
    • /
    • 2012
  • Dirofilaria (D.) immitis is an important canine parasitic nematode in dogs. D. immitis parasitizes the right ventricle and pulmonary artery of dogs. An ivermectin and pyrantel pamoate compound (IPPC) was administered to dogs naturally infected with this parasite. IPPC is composed of 68.0, 136.0 and $272.0{\mu}g$ of ivermectin and 57.0, 114.0 and 227.0 mg pyrantel pamoate for small, middle, and large animals. Ivermectin has activity against nematodes and ectoparasites in dogs. Pyrantel pamoate is also effective against nematodes in dogs. Our results showed that this drug combination has good efficacy in D. immitis infected dogs.

Anthelminthic efficacy of combined preparation of pyrantel pamoate and oxantel pamoate on human intestinal nematodes (Pyrantel pamoate 및 Oxantel pamoate 합제(合劑)의 장내선충류(腸內線蟲類)에 대(對)한 구충효과(驅蟲效果))

  • Cho, Seung-Yull
    • The Korean Journal of Pharmacology
    • /
    • v.12 no.1
    • /
    • pp.69-73
    • /
    • 1976
  • A combined syrup preparation of pyrantel pamoate and oxantel pamoate containing 50mg/ml of respective anthelminthics was evaluated on the efficacy to treat the human intestinal nematodes. Total 24 cases were treated with oral administration of above preparation 10 mg/kg body weight by single dose. The results were summarized as follows: 1. Out of 21 cases of Ascaris lumbricoides infection, 19 (90.5%) turned to be egg negative on 21 days after treatment and egg-reduction rate was 99.7%. 2. 17 cases out of 19 cases infected with Trichocephalus trichiurus were egg negative after treatment (84.2%) and egg reduction rate was 60.6%. 3. As for Ancylostoma duodenale infection, egg negative conversion rate was 88.9% and egg reduction rate was 98.1% by single oral administration among 9 infected cases. 4. In Enterobius vermicularis infection, all of 17 cases gave negative anal swab on 21th day after the treatment. From the above results, it was assumed that the anthelminthic activities of pyrantel pamoate and oxantel pamoate were not potentiated by the mixture of two kinds of drugs but showed simple additive effect.

  • PDF

Pyometra by Streptococcus sp. infection in a Cat (고양이에서 Streptococcus sp. 감염에 의한 자궁농축증 1례)

  • 이주명;남치주
    • Journal of Veterinary Clinics
    • /
    • v.18 no.4
    • /
    • pp.434-437
    • /
    • 2001
  • A female Russian blue cat has invited Animal Hospital because of diarrhea after the mating. The eggs on internal parasite and Giardia sp. were diagnosed in the feces floating test, and treated with metronidazole, pyrantel pamoate and antibiotics. There were no diarrheal sign in the reevaluation, but anorexia, polydipsia, polyuria, and vaginal discharge was newly induced. Streptococcus sp. was inspected by smearing of vaginal discharge, and enlarge-ment of uterus was evaluated by x-ray examination. This case was confirmed as pyometra and recovered by ovariohysterectomy on the basis of that examination. The rate of incidence in feline pyometra is not so high as in the canine.

  • PDF

Epidemiological Studies on Ascaris lumbricoides Reinfection in Rural Communities in Korea II. Age-specific Reinfection Rates and Familial Aggregation of the Reinfected Cases (한국 농촌지역의 회충재감염에 대한 역학적 조사연구 ll. 연령별 재감염률 및 재감염의 가족집적성)

  • 채종일;서병양이순형조승열
    • The Korean Journal of Parasitology
    • /
    • v.21 no.2
    • /
    • pp.142-149
    • /
    • 1983
  • Epidemiological studies on the reinfetion pattern of Ascaris lumbricoides were undertaken by means of blanket mass chemotherapy and worm collection in a rural village in Korea, during 1977~1980. The study objectives were to determine the age (sex)-specific reinfection rate during 2, 4, 6 and 12 months through repeated mass chemotherapy with pyrantel pamoate, and to observe the familial aggregation tendency of the reinfected cases. The results obtained are as follows: 1. The age (sex)-reinfection curve revealed that the reinfection rate is much higher in younger individuals than in olders in all of 4 kinds of interval chemotherapy groups. The highest reinfection rate and the highest burden of reinfected worms were observed in preschool children, followed by primary school students. Such fluctuation in the age-specific reinfection rates was more pronounced in males than in females. 2. There was noted a significant tendency of familial aggregation among the reinfected cases. It is suggested that reinfection occurs never randomly but preferably to the members of certain household families. From these reinfection analyses, it is inferred that the principal mode of A. lumbricoides transmiSSIOn in the surveyed rural area is likely to be of 'dooryard type', in which case children and certain family members are more preferably reinfected. It is also suggested that the preschool children should be included in the primary targets of mass control programme.

  • PDF

Epidemiological Studies on Ascaris lumbricoides Reinfection in Rural Communities in Korea 1. The Relationship between Prevalence and Monthly Reinfection Rate (한국 농촌지역의 회충재감염에 대한 역학적 조사연구 I. 현재감염률과 월재감염률의 상관관계)

  • 채종일
    • The Korean Journal of Parasitology
    • /
    • v.21 no.2
    • /
    • pp.135-141
    • /
    • 1983
  • The epidemiological relationship between the current prevalence and monthly reinfection rate of Ascaris lumbricoides was observed in rural communities in Korea by means of blanket mass chemotherapy and worm collection for measurement of the prevalence and reinfection rates. During the period from 1975 to 1980, a total of 4,466 inhabitants in 10 different localities were treated with 10 mg/kg of pyrantel pamoate and 2 days' whole stools were collected from 2,547 inhabitants. The stools were examined for the presence of expelled adult and/or young worms, which represent the prevalence and reinfection rates for past 2 months respectively. After then, the obtained rates were correlated each other applying the timeprevalence curve proposed by Hayashi. It was observed that the prevalence (overall worm positive rate) and worm burden per individual ranged by areas from 13. 6 to 72. 3% and 1.4~10. 2 respectively. The calculated monthly reinfection rates (X) (from young worm positive rates) according to areas were in the range, 2.6~16.2%, and clearly correlated with the current prevalence (Y) under the equation, $Y=1-(l-X)^{7.2}$ where 7.2 is time in month. The equation means that after one time mass chemotherapy the period needed to attain equilibrium of prevalence again would be about 7~8 months. And it is inferred that the majority of reinfected worms in human host turn over every 7~8 months.

  • PDF

Prevalence, Worm Burden and Other Epidemiological Parameters of Ascaris lumbricoides Infection in Rural Communities in Korea (한국 농촌지역의 회충 감염율, 감염량 및 역학적 변수)

  • 채종일;금구진
    • The Korean Journal of Parasitology
    • /
    • v.23 no.2
    • /
    • pp.241-246
    • /
    • 1985
  • The epidemiological status of ascariasis was analyzed in 8 rural villages in Korea, through observation of its epidemiological parameters such as prevalence, worm burden and basic reproductive rate. Total 978 inhabitants were subjected to stool examination and recovery of worms after chemotherapy with pyrantel pamoate. The results were as follows: 1. The worm positive rate in each village was 16.5~79.5%, while the egg positive rate was 9~18% lower, 3.3~66.7%. The average worm burden (among all inhabitants) ranged from O. 21 to 8. 44 by villages and the frequency of cases with each worm burden showed negative binomial distributions with 'k' values of O. 38-0. 54. 2. The prevalence rates (worm) in each village was almost identical with the theoretical ones from Anderson and May's equation; $p=1-(1+M^*/k)^{-k}$, where 'p' is worm prevalence and '$M^*$' equilibrium average worm burden. The basic reproductive rate 'R' was calculated from 1.03 to 2.11. lt is suggested that, although 'R' in lower endemic areas is approaching to the breakpoint of reinfection (R=1), control programs of ascariasis in Korea should be continued until it becomes below the level nationwidely.

  • PDF

Prenatal effect of pyrantel pamoate on several hematological parameter of offspring in mice

  • Abdulwahab.A.Noorwall;Ghazi M. Al-Hachim;Award -Omar
    • Archives of Pharmacal Research
    • /
    • v.9 no.2
    • /
    • pp.87-91
    • /
    • 1986
  • In attempt to develop a drug delivery system using serum albumin microspheres, bovine serum albumin microspheres containing antitumar agent. Cytarabine, were prepared. The shape, surface characteristics, size distribution, behavior of in vivo distribution, drug release behavior, and degradation of albumin microsphers in animal liver issue homogenate and proteolytic enzyme were investigated. The shape of albumin microspheres was spherical and the surface was smooth and compact. The size distribution of the albumin microspheres was effected by dispertion forces during emulsification and albumin concentration. Distribution of albumin microspheres after imtravenous administration in rabbit was achieved immediately. In vitro, albumin microsphere matrix was so hard that it retained most of cytarabine except initial burst during the first 10 minutes, and the level of drug release during the initial burst was affected by heating temperature, drug/albumin microsphere matrix was so hard that it retained most of cytarabine except initial burst during the first 10 minutes, and the level of drug release during the initial burst was affected by heating temperature, drug/albumin concentration ratio and size distribution. After drug release test, the morphology of albumin microspheres was not changed. Albumin microsphere matrix was degraded by the animal liver issue homogenate and proteolytic enzyme. The degree of degradation was affected by heating temperature.

  • PDF

Evaluation of Cellotape Anal Swabs in the Diagnosis of enterobiasis (요충층에 있어서 항문주위 도말법의 검토)

  • Kim, Jong-Seong;Choi, Hyang-Hee;Joo, Kyoung-Hwan;Rim, Han-Jong
    • Journal of agricultural medicine and community health
    • /
    • v.12 no.1
    • /
    • pp.94-101
    • /
    • 1987
  • Enterobiasis is common helminthic infections found in man. But control of this disease is still troublesome because of its difficulty in the d diagnosis and prevention of infection. Considering the difficulty of accurate diagnosis of pinworm infection, which is very common and somewhat pathogenic, reevaluation of cellotape anal swab method for the diagnosis of enterobiasis was performed. A total of 147 children ranging the ages of 1-12 years in 3 orphanages in the suburbs of Seoul, Korea was subjected for this study. Repeated cellotape anal swabs were carried out against 70 children, 7 times for 3 days interval, in the morning 6am. Finally 10 mg/kg body weight pyrantel pamoates were given to all children including egg negative cases and whole stools of 3 following successive days were collected for the confirmation of residual worm ourden at the time of treatment. Cellotape anal swabs were also performed to another 77 children at 6am, 3pm, 9pm, twice for 3 days interval. The resultant findings were summarized as follows; 1) While the each time average detection rate of Enterobius egg was 28.8% in this study group, the accumulative detection rate up to 7th examination was 62.8%. The accumulative detection rate rose continuously up to 6th examination. 2) After administration of pyrantel pamoate 10 mg/kg body weight, final infection rate was increased to 72.9% by adding worm positive cases who didn't show any evidence of infection in the cellotape anal swabs. 3) Although pinworms were detected in 35 among 70 children treated, 7 cases (20%) of them were egg negative cases in 7 consecutive cellotape anal swabs. 4) Pinworms were expelleded in 14 (87.5%) among 16 children whose swab result was positive in the last examination which was done concurrently with drug administration. 5) Estimated infection rate calculated by best asymptotically normal estimate of Neuman from Moriya's modification revealed 71.5% similar to 72.9% of present results. 6) The result of anal swab performed at 6am was higher than that of 3pm or 8pm. In conclusion, cellotape anal swab method for Enterobius vermicularis infection was considered as method having relatively high positive accuracy. However to gain the reliable infection rate, at least 6 examination is required in the group with 25-30% infection rate by single swab. Moriya's modification of Neuman could be used efficiently in the mass control of this diease for the estimation of true infection rate of E. vermicularis in the sampled population.

  • PDF

Echinochasmus caninus n. comb. (Trematoda: Echinostomatidae) Infection in Eleven Riparian People in Khammouane Province, Lao PDR

  • Chai, Jong-Yil;Chang, Taehee;Jung, Bong-Kwang;Shin, Hyejoo;Sohn, Woon-Mok;Eom, Keeseon S.;Yong, Tai-Soon;Min, Duk-Young;Phammasack, Bounlay;Insisiengmay, Bounnaloth;Rim, Han-Jong
    • The Korean Journal of Parasitology
    • /
    • v.57 no.4
    • /
    • pp.451-456
    • /
    • 2019
  • Adult specimens of Echinochasmus caninus n. comb. (Verma, 1935) (Trematoda: Echinostomatidae) (syn. Episthmium caninum Yamaguti, 1958) were recovered from 11 riparian people who resided along the Mekong River in Khammouane Province, Lao PDR. In fecal examinations done by the Kato-Katz technique, the cases revealed eggs of Opisthorchis viverrini/minute intestinal flukes, hookworms, and in 2 cases echinostome eggs. To recover the adult helminths, praziquantel 30-40 mg/kg and pyrantel pamoate 10-15 mg/kg in a single dose were given and purged with magnesium salts. Various species of trematodes (including O. viverrini and Haplorchis spp.), cestodes, and nematodes were recovered from their diarrheic stools. Among the trematodes, small echinostome flukes (n=42; av. 3.8 specimens per case) of 0.7-1.2 mm in length are subjected in this study. They are morphologically characterized by having 24 collar spines interrupted dorsally and anterior extension of vitellaria from the cirrus sac or genital pore level to the posterior end of the body. Particularly based on this extensive distribution of vitellaria, the specific diagnosis was made as Echinochasmus caninus. The cases were co-infected with various other helminth parasites; thus, clinical manifestations specific for this echinostome infection were difficult to determine. The present paper describes for the first time human E. caninus infections in Lao PDR. Our cases marked the 4-14th human infections with this echinostome around the world following the 3 previous cases reported from Thailand.