• Title, Summary, Keyword: respiratory disease

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A Case of Solitary Fibrous Pleura Tumor Associated with Severe Hypoglycemia: Doege-Potter Syndrome

  • Jang, Jong Geol;Chung, Jin Hong;Hong, Kyung Soo;Ahn, June Hong;Lee, Jae Young;Jo, Jae Ho;Lee, Dong Won;Shin, Kyeong Cheol;Lee, Kwan Ho;Kim, Mi Jin;Lee, Jung Cheul;Lee, Jang Hoon;Lee, Jae Kyo
    • Tuberculosis and Respiratory Diseases
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    • v.78 no.2
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    • pp.120-124
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    • 2015
  • Solitary fibrous tumor of the pleura (SFTP) is a rare primary intrathoracic tumor that arises from mesenchymal tissue underlying the mesothelial layer of the pleura. It usually has an indolent clinical course. The hypoglycemia that accompanies SFTP was first described by Doege and Potter independently in 1930, hence the eponym Doege-Potter syndrome (DPS). The incidence of DPS is reported to be ~4%. In this report, we present a typical case of DPS that was cured through complete surgical resection.

Role of folP1 and folP2 Genes in the Action of Sulfamethoxazole and Trimethoprim Against Mycobacteria

  • Liu, Tianzhou;Wang, Bangxing;Guo, Jintao;Zhou, Yang;Julius, Mugweru;Njire, Moses;Cao, Yuanyuan;Wu, Tian;Liu, Zhiyong;Wang, Changwei;Xu, Yong;Zhang, Tianyu
    • Journal of Microbiology and Biotechnology
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    • v.25 no.9
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    • pp.1559-1567
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    • 2015
  • The combination of trimethoprim (TMP) and sulfamethoxazole (SMX) has been shown to be active against Mycobacterium tuberculosis (Mtb) in clinical tuberculosis (TB) treatment. However, the mechanism of action of TMP-SMX against Mtb is still unknown. To unravel this, we have studied the effect of TMP and SMX by deleting the folP2 gene in Mycobacterium smegmatis (Msm), and overexpressing the Mtb and Msm folP1/2 genes in Msm. Knocking out of the folP2 gene in Msm reduced the minimum inhibitory concentration of SMX 8-fold compared with wild type. Overexpression of the folP1 genes from Mtb and Msm increased the MICs by 4- and 2-fold in Msm for SMX and TMP, respectively. We show a strong correlation between the expression of folP1 and folP2 genes and TMP-SMX resistance in mycobacteria. This suggests that a combination of FolP2 inhibitor and SMX could be used for TB treatment with a better outcome.

The Relationship between Oral Disease and Respiratory Disease in the Elderly (임상가를 위한 특집 1 - 노년의 구강 질환과 호흡기 질환의 관계)

  • Jeong, Jin-Seok;Heo, Seok-Mo
    • The journal of the Korean dental association
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    • v.51 no.9
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    • pp.494-500
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    • 2013
  • Recently, several researches indicated the relationship between oral condition and respiratory disease such as pneumonia and chronic obstructive pulmonary disease (COPD). Respiratory disease is known as common chronic disease in the elderly increasing mortality and morbidity. In this study, we have reviewed the association between oral disease and respiratory disease in the elderly. The related data were searched and collected from abroad and domestic studies. The studies included the randomized controlled clinical trials (RCTs), longitudinal, cohort, case-control, and systematic review studies. With the data from the studies, we concluded that poor oral hygiene or periodontal disease can influence the pneumonia in the elderly. Further studies will be needed to investigate the association between oral disease and COPD.

A Case of IgG4-Related Disease Presenting as Massive Pleural Effusion and Thrombophlebitis

  • Choi, Jong Hyun;Sim, Jae Kyeom;Oh, Jee Youn;Lee, Eun Joo;Hur, Gyu Young;Lee, Seung Heon;Lee, Sung Yong;Kim, Je Hyeong;Lee, Sang Yeub;Shin, Chol;Shim, Jae Jeong;In, Kwang Ho;Kang, Kyung Ho;Min, Kyung Hoon
    • Tuberculosis and Respiratory Diseases
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    • v.76 no.4
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    • pp.179-183
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    • 2014
  • Immunoglobulin (Ig) G4-related disease is a recently recognized systemic fibroinflammatory condition characterized by a lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells with elevated circulating levels of IgG4. The disease can either be localized to one or two organs, or present as diffuse multi-organ disease. Furthermore, lesions in different organs can present simultaneously or metachronously. In the pulmonary manefestations, lesions associated with IgG4-related disease have been described in the lung parenchyma, airways and pleura, as well as the mediastinum. We report a case of IgG4-related disease presenting as massive pleural effusion and thrombophlebitis.

One-Step Engineering of a Stable, Selectable Marker-Free Autoluminescent Acinetobacter baumannii for Rapid Continuous Assessment of Drug Activity

  • Jiang, Huofeng;Gao, Yamin;Zeng, Sheng;Wang, Shuai;Cao, Zhizhong;Tan, Yaoju;Yin, Huancai;Liu, Jianxiong;Zhang, Tianyu
    • Journal of Microbiology and Biotechnology
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    • v.29 no.9
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    • pp.1488-1493
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    • 2019
  • The rising cases of multidrug-resistant Acinetobacter baumannii (Ab) and the lack of effective drugs call for quick attention. Here, based on a Tn7 transposon and Xer/dif system, we constructed a stable, selectable marker-free autoluminescent Ab capable of producing visible light without extra substrates. Utilization of this autoluminescent reporter strain has the potential to reduce the time, effort and costs required for the evaluation of activities of anti-Ab drug candidates in vitro.

Disease Prevalence, Parent's Educational Needs, and Disease Management according to Severity of Respiratory Infections in Early Childhood (영유아 호흡기 감염 중증도에 따른 이환실태, 부모의 교육요구 및 관리수행정도)

  • Han, Hye-Yul;Park, Sun-Jung;Lee, Myung Nam;Kang, Kyung-Ah
    • Child Health Nursing Research
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    • v.21 no.3
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    • pp.227-235
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    • 2015
  • Purpose: The purpose of this study was to investigate disease prevalence, parent's educational needs, and disease management according to severity of respiratory infections in early childhood. Methods: Participants for this study were 173 mothers whose child was admitted to I university hospital in Seoul and whose child was an infant or toddler. Data were collected from December, 17, 2014 to February, 15, 2015 using self-report structured questionnaires. Data were analyzed using IBM/SPSS 21.0 program. Results: There were significant differences in the severity of respiratory infection according to neonatal admission due to dyspnea, feeding type, atopic dermatitis in the infant or allergic disease in father and siblings. Parent's educational needs for the severe respiratory infection group were higher than for the non-severe group. Parent's disease management for the severe respiratory infection group was lower than the non-severe group. Conclusion: As important care factors in neonatal admissions include dyspnea, cow milk feeding, eczema, family history of allergies, parent's educational needs and disease management, they should be considered when caring for young children with respiratory infections and their parents.

THE MANAGEMENT OF RESPIRATORY DISEASES IN DOGS & CATS;FOCUSED ON FLUID AND OXYGEN THERAPY

  • Hyun, Chang-Baig
    • Proceedings of the Korean Society of Veterinary Clinics Conference
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    • pp.166-197
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    • 2006
  • Respiratory diseases in dogs and cats can be classified into respiratory problems brought about as a result of a specific abnormality of the respiratory system; so called primary respiratory disease, and bronchopulmonary problems which occur as a consequence of heart failure; so called secondary respiratory disease. This section will concentrate predominantly on considerations regarding the treatment of primary respiratory diseases. This includes agents used to facilitate bronchodilation, to reduce coughing and various expectorants and mucolytics. In addition, the optimal fluid therapy and various ways of oxygen delivery with complication will be discussed with emphasis In order to understand the indications for, and action of, various drugs used in the treatment of respiratory disease an understanding of normal respiratory physiology is important and these considerations is described in this section for helping to understand further for readers.

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