• Title, Summary, Keyword: risk assessment

Search Result 4,341, Processing Time 0.051 seconds

Regulatory Aspect of Risk Assessment and Management

  • Lee, Hyomin;EunkyungYoon;Jeeyeun Han
    • Toxicological Research
    • /
    • v.17
    • /
    • pp.17-24
    • /
    • 2001
  • Risk assessment is useful tool making good decisions on the risks of certain hazardous com-pound and suggests safe margin through scientific process using toxicological data, statistical tool, exposure value and relevant variants. The goal of risk management is to protect the public health from hazardous compound based on result of risk assessment having reality. For the suggestion of exact man-aging information, risk assessment must be designed to represent a "plausible estimate" of the exposure to the individuals and to minimize uncertainty. Risk assessment methodology and knowledge are expected to change more rapidly than before and up-to-date methodology should be applied in regulatory aspects through the Agency. For the useful application of risk assessment, the communication between the risk assessor and the risk manager is needed before the initiation of the risk assessment and upon its completion. Generally, the risk assessment itself as a practical tool in the regulatory decision making process would be regarded with social economic impact.ic impact.

  • PDF

Application of Toxicogenomic Technology for the Improvement of Risk Assessment

  • Hwang, Myung-Sil;Yoon, Eun-Kyung;Kim, Ja-Young;Son, Bo-Kyung;Jang, Dong-Deuk;Yoo, Tae-Moo
    • Molecular & Cellular Toxicology
    • /
    • v.4 no.3
    • /
    • pp.260-266
    • /
    • 2008
  • Recently, there has been scientific discussion on the utility of -omics techniques such as genomics, proteomics, and metabolomics within toxicological research and mechanism-based risk assessment. Toxicogenomics is a novel approach integrating the expression analysis of genes (genomic) or proteins (proteomic) with traditional toxicological methods. Since 1999, the toxicogenomic approach has been extensively applied for regulatory purposes in order to understand the potential toxic mechanisms that result from chemical compound exposures. Therefore, this article's purpose was to consider the utility of toxicogenomic profiles for improved risk assessment, explore the current limitations in applying toxicogenomics to regulation, and finally, to rationalize possible avenues to resolve some of the major challenges. Based on many recent works, the significant impact toxicogenomic techniques would have on human health risk assessment is better identification of toxicity pathways or mode-of-actions (MOAs). In addition, the application of toxicogenomics in risk assessment and regulation has proven to be cost effective in terms of screening unknown toxicants prior to more extensive and costly experimental evaluation. However, to maximize the utility of these techniques in regulation, researchers and regulators must resolve many parallel challenges with regard to data collection, integration, and interpretation. Furthermore, standard guidance has to be prepared for researchers and assessors on the scientifically appropriate use of toxicogenomic profiles in risk assessment. The National Institute of Toxicological Research (NITR) looks forward to an ongoing role as leader in addressing the challenges associated with the scientifically sound use of toxicogenomics data in risk assessment.

Human Health Risk Assessment of Benzene from Industrial Complexes of Chungcheong and Jeonla Province (충청·전라지역 산업단지 주변지역에서의 벤젠 인체 위해성 평가)

  • Jang, Yong-Chul;Lee, Sungwoo;Shin, YongSeung;Kim, Heekap;Lee, Jonghyun
    • Journal of Environmental Impact Assessment
    • /
    • v.20 no.4
    • /
    • pp.497-507
    • /
    • 2011
  • This research studied human health risk assessment of benzene from industrial complexes of Chungcheong Province (Seosan industrial complex) and Jeonla Province (Iksan industrial complex and Yeosoo industrial complex). The residents near the industrial complexes areas can be often exposed to volatile organic compounds (e.g., benzene, toluene, xylenes) through a number of exposure pathways, including inhalation of the organic pollutant via various environmental matrices (air, water and soil), contaminated water, and soil intake. Benzene is well known to be a common carcinogenic and toxic compound that is produced from industrial and oil refinery complexes. In this study, a number of samples from water, air, and soil were taken from the residential settings and public school zones located near the industrial complex sites. Based on the carcinogenic risk assessment, the risk estimates were slightly above $10{\times}10^{-6}$ at all three industrial sites. According to deterministic risk assessment, inhalation was the most important route. The distribution of benzene in the environment would be dependent on vapor pressure, and the physical property influencing the extent of the potential risks. Non-carcinogenic risk assessment of benzene shows that the values of Hazard Index(HI) were much lower than 1.0 at all industrial complexes. Therefore, benzene was not a cause of concern in terms of non-carcinogenic risk posed to the residents near the sites. When compared to probabilistic risk assessment, the CTE(central tendency exposure) cancer risk values of deterministic risk assessment were close to the mean values predicted by the probabilistic risk assessment. The RME(reasonable maximum exposure) values fell within the range of 95% to 99.9% estimated by the probabilistic risk assessment. Since the values of carcinogenic risk assessment were higher than $10{\times}10^{-6}$, further detailed monitoring and refined risk assessment for benzene may be warranted to estimate more reliable and potential inhalation risks to receptors near the industrial complexes.

A Study on the Implementation of Risk Assessment System at Workplace in Korea (우리나라의 사업장 위험성평가 제도 실시에 관한 연구)

  • Jung, Jin Woo
    • Journal of the Korean Society of Safety
    • /
    • v.29 no.3
    • /
    • pp.121-128
    • /
    • 2014
  • Risk assessment system which is the point of occupational safety and health management system is recognized to be effective to prevent industrial accident and occupational disease internationally. Ministry of Employment and Labor developed guidance on risk assessment at workplace recently. This guidance presents standard model on risk assessment at workplace. However, enterprises may be confronted with many questions in the process of introducing and operating risk assessment. For risk assessment to be implemented properly and effectively at workplace, there are various questions that need to be considered in advance, including giving shape to standard on risk evaluation and clarifying the implementation system at workplace in advance. Also for risk assessment to be revitalized at workplace, several policy matters need to be settled. First, an administrative agency should present the implementation method of risk assessment more concretely. Secondly, it is necessary for an administrative agency to develop and spread various detailed manual, models and good practices related to risk assessment. Thirdly, a government agency need to apply an incentive & disadvantage policy actively to risk assessment.

The Risk Assessment Effects of SCM and the Strategy of Risk Management on Supply Chain Performance (공급사슬 위험평가 및 위험관리전략이 공급사슬 운영성과에 미치는 영향)

  • Kim, Dong Jeong;Lee, Young Jai
    • Journal of Information Technology Applications and Management
    • /
    • v.21 no.4
    • /
    • pp.173-186
    • /
    • 2014
  • This study outlines possible risk factors in the SCM of a company and correlates risk assessment, the strategy of risk management, and the supply chain performance. The data is surveyed from an international Korean company and is analyzed by the structure equation model of actual proof. The research model verifies the correlation between the risk assessment, the strategy of risk management, and the supply chain performance as dependent variables after the risk factors of the SCM are defined as independent variables. The research shows that there are consecutive links among the risk factors of the SCM, the risk assessment, and the strategy of risk management. The strategy of risk management was conclusively determined to have an effect on supply chain performance. Therefore, improving the supply chain performance of a company requires the constructive process for risk management based on a correlation between risk assessment and the strategy of risk management.

The Nature of Risk Assessment

  • The Korean Society for Preventive Medicine The Korean Society for Preventive Medicine
    • 대한예방의학회:학술대회논문집
    • /
    • /
    • pp.23-56
    • /
    • 1994
  • Recent criticisms of the conduct and use of risk assessment by regulatory agencies have led to a wide range of proposed remedies, including changes in regulatory statutes and the development of new methods for assessing risk. The mandate to this Committee was more limited. Our objective was to examine whether alterations in institutional arrangements or procedures, particularly the organizational separation of risk assessment from regulatory decision-making and the use of uniform guidelines for inferring risk from available scientific information, can improve federal risk assessment activities. Before undertaking to determine whether organizational and procedural reforms could improve the performance and use of risk assessment in the federal government, the Committee examined the state of risk assessment and the regulatory environment in which it is performed. In this chapter, we define risk assessment and differentiate it from other elements in the regulatory process, analyze the types of judgments made in risk assessment, and examine its current government context. Because one chronic health hazard, cancer, was highlighted in the Committee's congressional mandate and has dominated public concern about public health risks in recent years, most of our report focuses on it. Furthermore, because activities in four agencies--the Environmental Protection Agency (EPA), the Food and Drug Administration (FDA), the Occupational Safety and Health Administration (OSHA), and the Consumer Product Safety Commission (CPSC)--have given rise to many of the proposals for changes in risk assessment practices, our review focuses on these four agencies. The conclusions of this report, although directed primarily at risk assessment of potential carcinogens as performed by these four agencies, may be applicable to other federal programs to reduce health risks.

  • PDF