• Title, Summary, Keyword: samhwangsasimtang

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The Antimicrobial Activity of Samhwangsasimtang against pseudomonas aeruginosa 38 isolated from an acne patient (여드름 환자에서 분리된 pseudomonas aeruginosa 38에 대한 삼황사심탕(三黃瀉心湯)의 효과)

  • Kwon, Do-Kyong;Seo, Bu-Il;Park, Ji-Ha;Roh, Seong-Soo;Kim, Seong-Mo;Koo, Jin-Suk;Lee, Eun-Sook
    • The Korea Journal of Herbology
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    • v.25 no.2
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    • pp.11-19
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    • 2010
  • Objective : I want to examine the antimicrobial activity of Samhwangsasimtang against pseudomonas aeruginosa 38 isolated from an acne patient. Method : Antimicrobial activity was assayed through the hot water extract from Samhwangsasimtang against pseudomonas aeruginosa 38 isolated from an acne patient. Result : The size of inhibition zone of Samhwangsasimtang extract was $12.6\;{\pm}\;0.04\;mm$. The optimal pH and temperature for the growth of isolated pseudomonas aeruginosa 38 were 6.0 and $37^{\circ}C$, respectively. The minimum inhibitory concentration of Samhwangsasimtang extract was $10\;{\pm}\;0.06\;{\mu\ell}$ and the antimicrobial activity of Samhwangsasimtang extract was not destroyed by the heat ($121^{\circ}C$ for 15 min) and not affected by pH. Conclusion : Reviewing this experimental result, it appeared that Samhwangsasimtang had efficacy against pseudomonas aeruginosa 38 isolated from an acne patient.

Antihyperlipidemic and antioxidant effects of Samhwangsasimtang aqua-acupuncture (삼황사심탕약침의 지질강하 및 항산화효과)

  • Lee, Eun;Lee, Joon-Moo
    • Journal of Pharmacopuncture
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    • v.8 no.1
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    • pp.51-57
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    • 2005
  • Effects of Samhwangsasimtang aqua-acupuncture at gansoo($B_{18}$) and chungwan($CV_{12}$) on antihyperlipidemic and antioxidant were investigated in rat fed high fat diet. Concentrations of triglyceride, free fatty acids, lipoprotein and glucose in plasma showed a tendency to decrease in the aqua-acupuncture groups. In plasma lipid composition, total cholesterol and LDL- cholesterol showed a tendency to decrease in aqua-acupuncture groups, however the values of HDL-cholesterol showed no significantly different in the treatment groups. Concentration of thiobarbituric acid reactive substances(TBARS) in plasma and liver showed a low in the aqua-acupuncture groups. The values of glutathione peroxidase(GSH-Px) and catalase(CAT) activity showed a tendency to increase in aqua-acupuncture groups. However the values of superoxide dismutase(SOD) activity showed no significantly different in the treatment groups.

Screening of 56 Herbal formulas covered by the National Health Insurance Service on Dementia-related Factors (국민 건강보험 급여 한약 처방 56종의 치매 주요 생리지표 및 신경세포 변화에 대한 효능 비교 연구)

  • Lim, Hye-Sun;Kim, Yu Jin;Kim, Yoon ju;Kim, Bu-Yeo;Jeong, Soo-Jin
    • The Journal of Korean Medicine
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    • v.39 no.3
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    • pp.1-16
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    • 2018
  • Objectives: The purpose of this study was to investigate the effects of 56 herbal formulae covered by the National Health Insurance Corporation (NHIC) on dementia-related biomarkers and neuronal cell changes. Methods: The 56 herbal formulae were extracted with 70% ethanol at $100^{\circ}C$ for 2 h. The antioxidant properties was measured by radical scavenging assay using ABTS+ radical. The acetylcholinesterase (AChE) activity was tested by Ellman's assay and $amyloid-{\beta}$ ($A{\beta}$) aggregation was determined using fluorescence method. To estimate the inhibitory effects of herbal formulae on neuronal cell death and inflammation using HT22 hippocampal cells and BV-2 microglia, respectively. Results: Among the 56 herbal formulae, Dangguiyukhwangtang, Banhasasimtang, Samhwangsasimtang, Cheongwiesan, Hwangryunhaedoktang, Banhabaekchulchunmatang, Jaeumganghwatang, Cheongseoikgitang, and Hoechunyanggyuksan has a significant inhibitory effects on acetylcholinesterase (AChE) activity. Doinseunggitang and Samhwangsasimtang exerted the effect on the inhibition of $amyloid-{\beta}$ ($A{\beta}$) aggregation. Additionally, 10 herbal formulae affected AChE and $A{\beta}$ aggregation revealed antioxidant activity as well as neuroprotective and anti-neuroinflammation effects in neuronal cell lines. Conclusions: 10 herbal formulae that have been shown to be effective against the major dementia markers have been shown to have antioxidant activity, neuronal cell protection and inhibition of brain inflammation. Further investigation of these herbal formulae will need to be validated in dementia animal models.