• Title, Summary, Keyword: supramolecular

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Supramolecular assembly of peptide molecules for applications in biological multivalent interactions

  • Lim, Yong-Beom;Park, So-Mi;Lee, Eun-Ji;Jeong, Hae-Mi;Ryu, Ja-Hyoung;Yang, Won-Young;Lee, Myong-Soo
    • Proceedings of the Polymer Society of Korea Conference
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    • pp.265-265
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    • 2006
  • Multivalent interactions, which are characterized by the simultaneous binding of multiple ligands on multiple receptors, are prevalent in biological system. We have shown that it is able to make a supramolecular aggregate coated with multiple functional molecules fairly easily by simply mixing one building block. In this particular example, a mannose-coated object was able to agglutinate bacterial cells with cognate binding partners through multivalent interactions. This kind of strategy can be applied in developing materials that can selectively remove pathogens. Supramolecular assembly of this type should be very useful in exploring multivalent biological interactions.

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Supramolecular Assembly toward Organic Nanostructures

  • Lee, Myong-Soo
    • Proceedings of the Polymer Society of Korea Conference
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    • pp.173-173
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    • 2006
  • We have explored a strategy to control the supramolecular nano-structures self-assembled from rigid segments through attachment of flexible chains through microphase separation and anisotropic arrangement. Supramolecular structures formed by self-assembly of rigid building blocks can be precisely controlled from 1-D layered, 3-D bicontinuous cubic to 2-D cylindrical structures by systematic variation of the type and relative length of the respective blocks. Furthermore, depending on the individual molecular architectures, rigid building blocks self-assemble into a wide range of supramolecular structures such as honeycomb, disk, cylinder, helix, tube, barrel stave, and nano-cage.

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Lanthanide-Cored Supramolecular Systems with Highly Efficient Light-Harvesting Dendritic Arrays towards Tomorrow′s Information Technology

  • Kim, Hwan-Kyu;Roh, Soo-Gyun;Hong, Kyong-Soo;Ka, Jae-Won;Baek, Nam-Seob;Oh, Jae-Buem;Nah, Min-Kook;Cha, Yun-Hui;Jin Ko
    • Macromolecular Research
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    • v.11 no.3
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    • pp.133-145
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    • 2003
  • We have developed novel lanthanide-cored supramolecular systems with highly efficient light-harvesting dendritic arrays for integrated planar waveguide-typed amplifiers. Er$^{3+}$ ions were encapsulated by the supramolecular ligands, such as porphyrins and macrobicyclics. The supramolecular ligands have been designed and synthesized to provide enough coordination sites for the formation of stable Er(III)-chelated complexes. For getting a higher optical amplification gain, also, the energy levels of the supramolecular ligands were tailored to maintain the effective energy transfer process from supramolecular ligands to erbium(III) ions. Furthermore, to maximize the light-harvesting effect, new aryl ether-functionalized dendrons as photon antennas have been incorporated into lanthanide-cored supramolecular systems. In this paper, molecular design, synthesis and luminescent properties of novel lanthanide-cored integrated supramolecular systems with highly efficient light-harvesting dendritic arrays will be discussed.d.

Design of Supramolecular Electrolytes for Solid State Dye-sensitized Solar Cells (고체형 염료감응 태양전지용 초분자 전해질 개발)

  • Koh, Jong-Kwan;Koh, Joo-Hwan;Seo, Jin-Ah;Kim, Jong-Hak
    • 한국신재생에너지학회:학술대회논문집
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    • pp.24-27
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    • 2009
  • Solid-state dye-sensitized solar cells (DSSCs) have been constructed employing supramolecular electrolytes with multiple hydrogen bonding. A supramolecule was facilely synthesized by one-pot reaction between the amines of methyl isocytosine (MIC) and the epoxy groups of poly(ethylene glycol diglycidyl ether) (PEGDGE) to produce quadruple hydrogen bonding units. Hydrogen bonding interactions and dissolution behavior of salt in supramolecular electrolytes are investigated. The ionic conductivity of the supramolecular electrolytes with ionic liquid, i.e. 1-methyl-3-propylimidazolium iodide (MPII) reaches $8.5{\times}10^{-5}$ S/cm at room temperature, which is higher than that with metal salt (KI). A worm-like morphology is observed in the FE-SEM micrographs of $TiO_2$ nanoporous layer, due to the connection of $TiO_2$ nanoparticles resulting from adequate coating by electrolytes. DSSCs employing the supramolecular electrolytes with MPII and KI exhibit an energy conversion efficiency of 2.5 % and 0.5 %, respectively, at 100 $mW/cm^2$, indicating the importance of the cation of salt. Solar cell performances were further improved up to 3.7 % upon introduction of poly(ethylene glycol dimethyl ether) (PEGDME) with 500 g/mol.

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Controlled enzymatic stability and release characteristics of supramolecular chiral peptide amphiphile nanofiber gels

  • Zengin, Aygul;Cinar, Goksu;Guler, Mustafa O.
    • Current Applied Physics
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    • v.17 no.5
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    • pp.785-792
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    • 2017
  • Supramolecular bioarchitectures formed by assembly of achiral or chiral building blocks play important roles in various biochemical processes. Stereochemistry of amino acids is important for structural organization of peptide and protein assemblies and structure-microenvironment interactions. In this study, oppositely charged peptide amphiphile (PA) molecules with L-, D- and mixture of ${\text\tiny{L}}$- and ${\text\tiny{D}}$-amino acid conformations are coassembled into supramolecular nanofibers and formed self-supporting gels at pH 7.4 in water. The enzymatic stability of the PA nanofiber gels was studied in the presence of proteinase K enzyme, which digest a broad spectrum of proteins and peptides. The structural changes on the chiral PA nanofibers were also analyzed at different time periods in the presence of enzymatic activity. Controlled release of a model cargo molecule through the chiral PA nanofiber gels was monitored. The diffusivity parameters were measured for all gel systems. Release characteristics and the enzymatic stability of the peptide nanofiber gels were modulated depending on organization of the chiral PA molecules within the supramolecular assemblies.

Supramolecular Hydrogels Instantaneously Formed by Inclusion Complexation between Amphiphilic Oligomers and $\alpha$-Cyclodextrins

  • Zhao, Sanping;Lee, Jong-Hwi
    • Macromolecular Research
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    • v.17 no.3
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    • pp.156-162
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    • 2009
  • Supramolecular hydrogels were instantaneously fabricated by mixing aqueous solutions of $\alpha$-cyclodextrins ($\alpha$-CDs) and amphiphilic methoxy (polyethylene glycol) (MPEG)-$\varepsilon$-caprolactone (CL) oligomer, which was synthesized via the ring-opening polymerization of the CL monomer using low-molecular-weight MPEG ($M_n$ of MPEG=2,000 g/mol) as an initiator. The supramolecular structure of the hydrogels was revealed by X-ray diffraction (XRD) analyses. Rheological studies of the hydrogels revealed an elastic character when the number of CL units in the oligomer was more than 2, and the obtained hydrogels showed high storage modulus but relatively low shearing viscosity due to the low-molecular-weight character of the oligomer, which was more preferable for use as an injectable delivery system. The physical properties of the hydrogels could be modulated by controlling the chain morphology and concentration of the oligomers, as well as the feed molar ratio of the oligomer to $\alpha$-CD. The components of the supramolecular hydrogels are biocompatible and can readily be eliminated from the body. These features render the supramolecular hydro gels suitable as drug delivery systems and tissue engineering scaffolds.

Supramolecular Nanomaterials Derived from Self-Assembly of Dendritic Building Blocks

  • Park, Chi-Young;Lee, Sang-Wha;Lim, Ji-No;Lim, Moon-Seob;Kim, Chul-Hee
    • Proceedings of the Polymer Society of Korea Conference
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    • pp.91-92
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    • 2006
  • The fine-tuned dendrons provide unique supramolecular self-assemblies in various environments such as in water, organic media, and solid-liquid interfaces. They form nanotubes, vesicles, thin films, columns, lamellar nanoribbons depending on the condition of self-assembly process. Unique characteristics of self-assembly of the amide dendrons are described. In addition, elucidation of the structural correlation between the building blocks and the assemblies, stabilization of assembled structure, and transformation of supramolecular assemblies by using external stimuli. Particular emphasis is placed on the formation of cyclodextrin-covered organic nanotubes derived from self-assembly of amide dendrons and their supramolecular transformation. Finally, unique biosensory characteristics of the self-assembled nanotubes will be discussed.

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Complex Ordering of Supramolecular Dendrimers in Confined Geometries.

  • Yoon, Dong-Ki;Choi, Myung-Chul;Kim, Yun-Ho;Kim, Mahn-Won;Jung, Hee-Tae
    • Proceedings of the Polymer Society of Korea Conference
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    • pp.189-189
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    • 2006
  • The self-assembly of supramolecular dendrimers allows the rapid construction of nanosized structures with regularly ordered features that depend on the shape of the molecules and the relative strength of the intra-and intermolecular interactions. Here we report on a dramatic improvement in the degree of control and selectivity in the orientation of fan-shaped supramolecular molecules over a large area, which has been achieved by confined geometries and applied fields. The order and orientation of supramolecular dendrimers can be controlled by surface anchoring in confined geometries. POM, SEM, TEM, AFM and XRD results show that the molecules form the complicated defect-ordering in the microchannels with different feature sizes. We show that these defect domains are strongly influenced by the boundary and feature size of the surfaces. This technique can be used to create a grain size in the plane of the film that is much larger than that which can be achieved using previously reported soft-material based pattering.

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Revesible Switching between Nematic Gel and Isotriopic Fluid Triggered by External Stimuli in Aqueous Self-Assembly of Supramolecular Nanocylinders

  • Ryu, Ja-Hyoung;Lee, Myong-Soo
    • Proceedings of the Polymer Society of Korea Conference
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    • pp.308-308
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    • 2006
  • We have demonstrated that the cylindrical micelles self-assembled from coil-rod-coil molecules can be interconnected by addition of a small amount of rod-coil-rod molecule as a bridging agent. Subsequently, these dynamic interconnections lead to stiff bundles composed of cylindrical micelles that are responsible for the formation of a reversible nematic gel. The results described here represent a significant example that dynamic bridging of supramolecular cylinders in aqueous solution can provide a useful strategy to construct one-dimensional nematic structure with three dimensional elastic properties.

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