• Title, Summary, Keyword: thrombocyte

Search Result 23, Processing Time 0.037 seconds

Effect of splenectomy on the blood and marrow megakaryocyte picture in dogs (견(犬)에 있어서 비장적출(脾臟摘出)이 혈액(血液) 및 골수거대핵세포상(骨髓巨大核細胞像)에 미치는 영향(影響))

  • Hong, Kyung-tae;Lee, Hyun-beom;Lee, Keun-woo
    • Korean Journal of Veterinary Research
    • /
    • v.33 no.2
    • /
    • pp.327-336
    • /
    • 1993
  • Present experiments were undertaken in order to clarify the effect of splenectomy on the hematology and marrow megakaryocyte picture and to know the genesis of postsplenectomy thrombocytosis in dogs. Six mongrel dogs weighing 8.5~18㎏ were used, of which three were splenectomized and the other three were laparotomized for comparison. Erythrocyte count, total and differential leukocyte counts, thrombocyte count and packed cell volume measurement were made using the blood samples. In addition, bone marrow samples obtained from the femur at 7th and 23rd day of the operation were examined for the number per low-power field, the diameter, and the distribution frequency of the megakaryocyte. From these experiments, following results were obtained : Erythrocyte count and packed cell volume showed significant decrease beginning on the 15th day of splenectomy. Total and differential leukocyte counts showed marked increase for the first 2 days of postsplenectomy. The thrombocyte count of splenectomized dogs increased from the 2nd day of the operation, reached to the peak count on the 15th day, and returned to the preoperation count by the 28th day. The megakaryocyte count per low-power field of the biopsied preparation increased in according to the increase in thrombocyte count. The megakaryocyte diameter of splenectomized dog showed no increase on the 7th or 23rd day of the operation. However, the distribution frequency of the larger megakaryocyte was higher in the splenectomized dogs than in the laparotomized dogs. The total plasma protein concentration showed no significant change after splenectomy or laparotomy. From these results, it may be concluded that the postsplenectomy thrombocytosis results from the increased megakaryocytopoesis or the activated thrombocytopoesis of the marrow megakaryocytes.

  • PDF

Live Blood Analysis on Interior Vascular Laser Irradiation Therapy and Exterior Vascular Laser Irradiation Therapy (혈관레이저 치료와 관련한 생혈액 검사의 진단 의미 고찰)

  • Kwon, Mi-Jung;Kim, Min-Kyu;Shin, Won-Tak;Heo, Jeung-Eun;Youn, Hyoun-Min;Kim, Su-Min;Kim, Won-Il
    • Korean Journal of Acupuncture
    • /
    • v.24 no.3
    • /
    • pp.91-103
    • /
    • 2007
  • Objectives : The purpose of this study was to investigate the usability of live blood analysis on interior and exterior vascular laser irradiation therapy. Methods : We had analyzed the changing forms of the live blood sample with microscope before and after vascular laser irradiation therapy of blood. The live blood analysis was operated on Rouleau of red cell, erythrocyte aggregation, thrombocyte aggregation, uric acid crystals, red crystals, protoplasts. First, we analyzed all patients on each item, then did same thing classified two groups, Interior and exterior. Results : Rouleau of red cell, erythrocyte aggregation, thrombocyte aggregation, uric acid crystals, red crystals, protoplasts were decreased significantly, after interior and exterior aggregation, uric acid crystals. Interior vascular laser irradiation therapy was more effective than interior on Rouleau of red cell, erythrocyte aggregation, thrombocyte aggregation, uric acid crystals. Interior vascular laser irradiation therapy was more effective than exterior on red crystals, protoplasts. Conclusions : This study suggests that live blood analysis has the usability on vascular laser irradiation therapy. Then according to interior and exterior vascular laser irradiation therapy, the result has some different on each item. So it is better that choose the method, interior or exterior, for more effective therapy.

  • PDF

Prognostic Significance of Basic Laboratory Methods in Non-Small-Cell-Lung Cancer

  • Kaya, Vildan;Yildirim, Mustafa;Demirpence, Ozlem;Yildiz, Mustafa;Yalcin, Aysen Yesim
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.14 no.9
    • /
    • pp.5473-5476
    • /
    • 2013
  • Background: In our study, the LDH, albumin, hemoglobin, neutrophile, thrombocyte, lymphocyte counts and prognostic significance of neutrophile-lymphocyte and thrombocyte-lymphocyte ratios in NSCLC derived from these counts obtained during regular examinations of patients were examined. Materials and Methods: Histopathologically diagnosed non-small-cell-lung cancer patients between 2008 and 2010 were included in the study. Before the treatment, full blood count including routine lymphocyte count, blood biochemistry examinations including liver (AST, ALT, total protein, Albumin), LDH and kidney (BUN, Cre) function tests were performed. Results: A total of 156 patients, 76 of whom (48.7%) were female and 80 of whom (51.3%) were male were included. Mean hemoglobin level was determined as 12. Overall survival was found to be significantly dependent on whether patients were anemic or not (p: 0.005). Mean LDH level was determined as 233.4. There was nosurvival difference between patients with and without high LDH (p: 0.532). In patients where NLR showed systemic inflammatory response, overall survival was 10.8 months whereas this duration was 19.6 months in patients where the systemic inflammatory response was negative (p: 0.012). In patients where TLR showed systemic inflammatory response, overall survival was 13.6 months whereas this duration was 21.9 months in patients where the systemic inflammatory response was negative (p: 0.04). Conclusions: Molecular methods have been changing rapidly in today's world and they manage the treatment besides defining the prognosis of patients. However, easily accessible and cheap laboratory parameters should be considered in the prognosis of patients besides these new methods.

Study on the Anti-oxidative Effects of Adenophorae Radix, Codonopsis lanceolatae Radix and Glehniae Radix Cum Rhizoma on Liver Cells Isolated from Oxidatively Stressed Rat (산화동물 모델 흰쥐 간세포에 대한 사삼(沙參), 양유근(羊乳根) 및 해방풍(海防風)의 항산화 효과 연구)

  • Min, Sang-Hong;Han, Hyo-Sang;Lee, Young-Jong
    • The Korea Journal of Herbology
    • /
    • v.24 no.3
    • /
    • pp.109-119
    • /
    • 2009
  • Objectives : The present study was purposed to compare Adenophorae Radix (henceforth AR), Codonopsis lanceolatae Radix (henceforth ClR) and Glehniae Radix cum Rhizoma (henceforth GRcR) concerning their anti-oxidant effect. Methods : We measured eythrocyte, leukocyte, thrombocyte, serum albumin, total bilirubin, LDL cholesterol, and glucose as well as SOD, GSH, catalase, NO, and MDA in the rat liver oxidatively stressed by AAPH. Results : 1. The oxidative stress-induced thrombocyte levels were significantly decreased in CIR-treated and GRcR-treated groups. 2. The oxidative stress-impaired SOD acitivities were significantly recovered in AR-treated and GRcR-treated groups. 3. The oxidative stress-reduced GSH contents were significantly increased in ClR-treated and GRcR-treated groups. 4. The oxidative stress-reduced catalase contents were significantly increased in all of the three groups. 5. The oxidative stress-induced NO productions were significantly decreased in all of the three groups. Conclusions : AR, ClR, and GRcR altogether showed the anti-oxidant effect in the rat liver oxidatively stressed by AAPH. The anti-oxidant properties of tAR, ClR, and GRcR seem to be similar even if those have different botanical properties and different medical efficacies in oriental medicine.

  • PDF

Clinical Study on the Effect of Exterior Vascular Laser Irradiation Therapy by Live Blood Analysis

  • Lee, Eun-Hyoung;Jeong, Jae-Ook;Min, Sung-Soon;Song, Su-Jin;Kim, Won-Ill
    • The Journal of Korean Medicine
    • /
    • v.26 no.4
    • /
    • pp.143-151
    • /
    • 2005
  • Objectives: The purpose of this study was to investigate the effect of exterior vascular laser irradiation therapy by live blood analysis. Methods: We analysed the changing forms of the live blood sample with a microscope before and after exterior vascular laser irradiation therapy of the blood. Results: Rouleau of red cells, erythrocyte aggregation of red cells, thrombocyte aggregation, uric acid crystals, red crystals, and protoplasts in blood were decreased significantly after exterior vascular laser irradiation therapy. Conclusions: This study suggests that exterior vascular laser irradiation will have positive effects in eliminating various effete matters in blood and will have efficacy in the treatment and prevention of cardiovascular system disorders and hyperlipidemia, caused by effete matters, or numbness and arthralgia caused by blood stagnancy and blood circulation disorder.

  • PDF

ALTERATION OF RADIATION-INDUCED HEMATOTOXICITY BY BU-ZHONG-YI-QI-TANG IN MOUSE

  • Jang, Jong-Sik;Kim, Sung-Ho
    • Journal of Radiation Protection and Research
    • /
    • v.33 no.3
    • /
    • pp.93-97
    • /
    • 2008
  • The purpose of this study reported here was to investigate the ability of Bu-Zhong-Yi-Qi-Tang (BZYQT), known to elevate hematopoietic functions, to protect mice undergoing treatment with whole body single gamma-irradiation. BZYQT was given (25 mg/kg B.W.) intraperitoneally at 36 and 12 hours before irradiation and 30 minute and 24 hours after irradiation. Recovery of neutrophil and lymphocyte counts was significantly stimulated by extract of BZYQT. Stimulated recovery by the extract from the BZYQT was also observed in thrombocyte. However, the anti-radiation effect of erythrocyte, hemoglobin and hematocrit was not as significant as that of leukocyte. Further studies are needed to better characterize the protective nature of BZYQT extract and its ingredients.

Late Biological Effect of Gamma Radiation and the Effect of Bu-Zhong-Yi-Qi-Tang on Radiation-Induced Late Biological Effect in Mice (감마선 조사 마우스의 만성장해와 보중익기탕 투여 효과)

  • Kim, Se-ra;Jo, Sung-kee;Kim, Sung-ho
    • Korean Journal of Veterinary Research
    • /
    • v.43 no.3
    • /
    • pp.323-331
    • /
    • 2003
  • We performed this study to determine the late biological effect of gamma radiation and effect of Bu-Zhong-Yi-Qi-Tang (BZYQT), a prescription of traditional Oriental medicine, on radiation-induced late biological effect (survival, hematological change, carcinogenesis) of mice irradiated with 3 Gy of gamma-radiation. There were little difference in body weights between normal and irradiated mice. Survival rate were decreased in irradiated mice and the survival rate and mean survival time of the groups treated with BZYQT were far better than the irradiation control group. A significant elevation of total leukocyte or lymphocyte counts was seen at week 4 and 12 of the group treated with BZYQT. Stimulated recovery by the extract from BZYQT was also observed in thrombocyte. Main gross findings of irradiated mice were appeared as enlargement of spleen, thymus and liver, tumorous nodules of lung and cyst or mass of ovary. Microscopically, there were various findings including hematopoietic and lymphoid tumor, lung cancer, ovarian cancer and cancer of other lesions. BZYQT reduced the incidence of tumor development. Further studies are needed to characterize better the protective nature of ingredients and active compounds.

The Effect Of Music Rope-skipping On Body Composition and Health Related Blood Components Of Middle School Students (음악줄넘기 운동이 남녀중학생의 신체조성과 건강관련 혈액성분에 미치는 영향)

  • Shin, Koon-Soo;Kim, Yong-Jae
    • Journal of Fisheries and Marine Sciences Education
    • /
    • v.23 no.4
    • /
    • pp.734-744
    • /
    • 2011
  • This study has examined the effect of music Rope-skipping on body composition and health related blood components of middle school students. The experiment has been performed for 12 weeks, varying the exercise intense depending on preliminary stage, elementary and intermediate stage and conclusion is as follows based on the change in body composition, blood components related to health before and after the experiment. All males and females showed decreased, but there were no statistically different in body fat mass and body fat percentage. Fat-free mass of males showed decreased and females had an increased, but there were no statistically different. Regarding body-mass index of males and females were on the decreased, but there were no statistically different. As for hematocrit of males and females statistically grew by about 4.53%(p<.05). The number of erythrocyte and leukocyte in males and females showed increased, but there were no statistically difference. Concerning hemoglobin of males and females showed a increased(p<.01). The number of thrombocyte of males and females were on the increased, but there were no statistically different. Cholesterol in males and females were on the decreased, but it was not statistically different. Blood glucose of males and females were on the decreased(p<.05).

Radioprotective Effect of Propolis on the Blood Corpuscle of a Mouse by SEM after X-irradiation on the Whole Body (전신 X-선 조사 후 마우스의 대동맥 혈구에서 SEM을 이용한 프로폴리스의 방사선방어효과 연구)

  • Ji, Tae-Jeong
    • Journal of radiological science and technology
    • /
    • v.31 no.1
    • /
    • pp.49-54
    • /
    • 2008
  • After x-ray 5Gy radiation on the whole body of a mouse using a linear accelerator, its leucocyte, erythrocyte, and platelet were observed by SEM. Also, after injecting propolis into the abdominal cavity, the radio-protective effect of blood corpuscles was studied. The observation of micromorphology in blood corpuscles revealed that the number of leukocyte, erythrocyte, and thrombocyte decreased in the experimental group and the lump got together in blood corpuscles after 10 and 20 days. In RBC, crack or break on the surface and poikilosperocytes were observed. In the irradiation group, the size of leucocytes was smaller than that in control group and the number of villus at the verge substantially decreased. The blood corpuscles in the propolis group, however, had the similar results to control group.

  • PDF

The Effect of Green Tea on Radion-induced Late Biological Effect in Mice (감마선을 조사 한 마우스에서 녹차 장기투여의 효과)

  • Kim, Se-Ra;Lee, Hae-Jun;Kim, Hyu-Kyung;Lee, Jin-Hee;Oh, Ki-Seok;Park, In-Chul;Oh, Heon;Cho, Sung-Ki;Kim, Sung-Ho
    • Journal of Veterinary Clinics
    • /
    • v.20 no.2
    • /
    • pp.159-165
    • /
    • 2003
  • This study was performed to determine the effect of green tea on the late biological effect (survival, hematological change, carcinogenesis) of mice irradiated with 3 Gy of gamma-radiation. There was little difference in body weights between normal and irradiated mice. Survival rate were decreased in irradiated mice and the survival rate and mean survival time of the groups treated with green tea were far better than the irradiation control group. An elevation of mean number of total leukocyte or lymphocyte counts was seen at week 12 of the group treated with green tea. Stimulated recovery by the extract from green tea was also observed in thrombocyte. Main gross findings of irradiated mice were appeared as enlargement of spleen, thymus and liver, tumorous nodules in lung and cyst or mass in ovary. Microscopically, there were various findings including hematopoietic and lymphoid tumor, lung cancer, ovarian cancer and cancer of other lesions. Green tea reduced the incidence of tumor development. Further studies are needed to characterize better the protective nature of active compounds.