• Title, Summary, Keyword: thymus

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In vitro Screening of Seaweed Extract on the Proliferation of Mouse Spleen and Thymus Cell

  • Seo, Young-Wan;Kang, Sung-Ho;Lee, Hee-Jung;Kim, You-Ah;Youn, Hyun-Joo;Lee, Burm-Jong;Chung, Ho-Sung
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.11 no.2
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    • pp.160-163
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    • 2006
  • A total number of 31 types of seaweed were assessed with regard to their effects on the proliferation of mouse spleen and thymus cells in a culture, using an MTT reduction assay. Acetone:dichloromethane (1:1) extracts of three seaweed plants: Derbesia marina, Sargassum sp., and Hisikia fuziformis, exhibited significantly positive effects on the survival of mouse spleen and thymus cells in vitro. The acetone:dichloromethane (1:1) extracts of Sargassum sp., in particular, much more potent effects on thymus cell activation than did any of the other types of seaweed. However, the methanol extracts of Sargassum ringgoldianium and Chondrus crispus exerted a stimulatory influence only on the proliferation of mouse spleen cells, whereas the methanol extracts of Grateloupia lanceolata exhibited significant cell proliferation properties in both spleen and thymus cells.

Effect of thymus extract on the activation of cytotoxic and accessory functions of tumor-associated macrophages

  • Shrivastava, Pratima;Singh, Sukh Mahendra;Singh, Nisha
    • Advances in Traditional Medicine
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    • v.4 no.1
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    • pp.9-17
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    • 2004
  • The present investigation was under taken to study whether the tumor-associated macrophages (TAM) of Daltons lymphoma (DL), a spontaneous transplantable murine T cell lymphoma can be activated to tumoricidal state by crude thymus extract. Intraperitoneal administration of thymus extract to DL-bearing mice resulted in activation of TAM with an enhanced IL-1, TNF and antigen presenting ability. It was found that treatment with thymus extract could also enhance the phagocytic and cytotoxic activity of TAM. However, only a marginal increase in arginase activity was observed. Till date to the best of our knowledge the effect of crude thymus extract on the activation of tumor associated macrophages has not been investigated, this study provides a new piece of information in the area of thymus therapy.

Identification of Differentially Expressed Genes between Neonatal and Peripubertal Rat Thymi Using $GeneFishing^{TM}$ Polymerase Chain Reaction

  • Kang, Da-Won;Kim, Gyu-Tae;Han, Jae-Hee
    • Reproductive and Developmental Biology
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    • v.31 no.1
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    • pp.55-60
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    • 2007
  • Aging causes thymus involution, and genes in thymus play an important role in the development of the immune system. In this study, we compared genes expressed in thymus of neonatal and peripubertal rats using annealing control primers (ACPs)-based GeneFishing polymerase chain reaction (PCR) and semiquantitative reverse transcription (RT)-PCR. We identified 10 differentially expressed genes (DEGs) with 20 ACPs. Of 10 DEGs, bystin-like, collagen type V alpha 1 (COL5A1), and T-cell receptor beta-chain segment 2 (TCRB2) that are related to immune-function were detected in rat thymus. Bystin-like and TCRB2 were up-regulated, while COL5A1 was down-regulated in peripubertal thymus. Semiquantitative RT-PCR confirmed postnatal changes in expression of bystin-like, COL5A1, and TCRB2. These results suggest that bystin-like, COL5A1, and TCRB2 could regulate immune function controlled in thymus as age increases.

마우스의 흉선에 미치는 7,12-Dimethylbenz[a]anthrancene의 영향

  • 이덕윤
    • Toxicological Research
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    • v.9 no.1
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    • pp.1-11
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    • 1993
  • This study was carried out to investigate the immunopathological effects of 7, 12-Dimethylbenz[a]anthracene(DMBA) on mouse thymus. DMBA was administered subcutaneously to BALB/C mice by interscapular single injection of 50 or 100 ng/g of body weight. Each DMBA treatment group and additional corn oil control group of mice were studied on day 1, 3, 7, 14 and 21 following the injection of DMBA. DMBA treatment resulted in marked decreases in weights and cellularity of thymus. Thymus weights were decreased by 50.6 and 66.0% at 21 days, respectively, after treatment of 50ng/g and 100 ng/g DMBA.

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A case of true thymic hyperplasia in the mediastinum with ectopic thymus in the neck (종격동 진성 흉선 증식증에 동반된 경부 이소 흉선 1례)

  • Kim, Hyun-Jung;Jang, Sun-Hwa;Park, Ji-Sook;Park, Eun-Sil;Seo, Ji-Hyun;Lim, Jae-Young;Park, Chan-Hoo;Woo, Hyang-Ok;Youn, Hee-Shang
    • Clinical and Experimental Pediatrics
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    • v.49 no.9
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    • pp.996-999
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    • 2006
  • True thymic hyperplasia and ectopic thymus are very rare in children. In embryologic aspect, thymus is distributed around cervical area and ends up in mediastinum. This case is simultaneous thymic hyperplasia of neck and mediastinum. Ectopic thymus in the neck and thymic hyperplasia in the mediastinum in children were reported 2 and 7 cases respectively in Korea. In Clinical aspects, these thymic hyperplasia were presented by mass. So we should suspect these benign condition to avoid unnecessary operation or biopsy. We report a case of true thymic hyperplasia in the mediastinum with ectopic thymus in the neck in a 4-month-old male infant and review the relevant literature. We believe this is the first reported case in the world of true thymus hyperplasia in the mediastinum with cervical ectopic thymus in the neck.

Influence of Host Age on Development and Morphological Parameters of the Parasitoid Nesolynx thymus Girault (Hymenoptera: Eulophidae), An Ecto-Pupal Parasitoid of the Uzi Fly, Exorista bombycis (Louis) (Diptera: Tachinidae)

  • Aruna A.S.;Manjunath D.
    • International Journal of Industrial Entomology
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    • v.12 no.1
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    • pp.45-49
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    • 2006
  • The present investigation was conducted to know the effects of host age on development and morphological characteristics of Nesolynx thymus, a gregarious ectopupal parasitoid of the uzi fly, Exorista bombycis, a serious en do-larval parasitoid of the silkworm, Bombyx mori L. For experimentation, 3 - 11 day-old pupae of E. bombycis were exposed to 2 day-old adults of N. thymus at $25{\pm}2^{\circ}C\;and\;60{\pm}10%$ RH. A highly significant negative correlation between host age and the following development and morphological characteristics of the parasitoid was observed: number of pupae parasitised, total adult recovery, sex ratio and recovery, longevity, body length, wing span, abdomen length, and abdomen width of females. The findings of the present study clearly demonstrate that various development and morphological parameters of N. thymus are influenced by the age of E. bombycis pupae.

Large Cell Neuroendocrine Carcinoma of the Thymus: A Two-Case Report

  • Yoon, Yong-Han;Kim, Jae-Ho;Kim, Kwang-Ho;Baek, Wan-Ki;Lee, Hyun-Kyu;Lee, Moon-Hee;Lee, Kyung-Hee;Kim, Lucia
    • Journal of Chest Surgery
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    • v.45 no.1
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    • pp.60-64
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    • 2012
  • A large cell neuroendocrine carcinoma (LCNEC) of the thymus is a very rare malignant tumor that has a very poor prognosis. The detailed clinical features of LCNEC are still unknown, including the long term prognoses and the definitive modalities of the treatment for LCNEC of the thymus. We are reporting 2 cases of an enlarged LCNEC of the thymus, both of which were diagnosed and treated by surgical resection followed by postoperative adjuvant chemoradiation therapy. Although recurrences and metastases of the LCNEC were noticed 1 and 4 years postoperatively for each case, aggressive surgical resection and adjuvant chemoradiation therapy may be helpful for a patient's long term survival.

A Case of Recurrent Spindle Cell Epithelial Tumor of Thymus-Like Differentiation (SETTLE) in the Glottis (성문에서 발생한 재발성 흉선상 방추상 상피세포 종양(Spindle Epithelial Tumor with Thymus-Like Differentiation, SETTLE) 1예)

  • Park, Woori;Choi, Nayeon;Chung, Man Ki
    • Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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    • v.26 no.2
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    • pp.133-136
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    • 2015
  • Spindle epithelial tumor with thymus-like differentiation (SETTLE) is an extremely rare type of thyroid tumor, with spares reports on its clinical course. SETTLE is derived from branchial pouch or thymic remnants, and classified as a low grade, malignant neoplasm due to its indolent growth and tendency to develop delayed metastasis. Therefore, stringent initial workups and long-term follow-up are required to prevent misdiagnosis. We present a case of recurrent spindle epithelial tumor with thymus-like differentiation (SETTLE) in the glottis of 57 year-old male patient, who had a history of surgical excision for the SETTLE from the thyroid gland 5 years ago. Transoral CO2 laser surgery was performed to remove the glottic tumor and there was no evidence of local recurrence at 11 months postoperatively.

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Effect of saltss on the entrapment of calf thymus DNA into liposomes

  • Kim, Chong-Kook;Lee, Beom-Jin
    • Archives of Pharmacal Research
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    • v.10 no.2
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    • pp.110-114
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    • 1987
  • To correlate the conformational changes of DNA (Calf Thymus) with entrapment of DNA into liposomes, the effect of ions ($Na^+$, $Mg^{++}$on the entrapment of calf thymus DNA into liposomes was investigated. The effect of divalent ion ($Mg^{++}$ on the structural changes of DNA indicated by decrease of observed ellipticity at 274 nm and nonspecific binding of DNA to lipid bilayers was greater than monovalent ion ($\Na^+$). But the efficiency of DNA encapsulated was not altered. These results show that entrapment of DNA into liposomes is not due to nonspecific binding and structural changes because of electrostatic forces but to mechanical capture of DNA by the internal aqueous space of liposomes although divalent ion contributes large structural changes and more nonspecific association of DNA with liposomes due to strong charges.

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Thymic Radioiodine Uptake Mimicking Metastatic Papillary Carcinoma in the Anterior Mediastinum (갑상선암 환자에서 전종격동의 전이성 암처럼 보이는 흉선의 방사성옥소 섭취)

  • Park, Chan-H.;Lee, Myoung-Hoon
    • The Korean Journal of Nuclear Medicine
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    • v.36 no.1
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    • pp.87-89
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    • 2002
  • A 30 year-old female patient with papillary thyroid carcinoma received her fifth radioiodine ablation therapy after the subtotal thyroidectomy. The scan, which was peformed one week after the last therapy, revealed residual uptake in the thyroid bed and uptake in the anterior mediastinum suggesting metastasis. However, further evaluation of the thorax with chest CT and camera-based FDG PET confirmed normal thymus without metastatic focus. Occasionally thymus remains intact in adult and has avidity for I-131 and FDG. Therefore, normal thymus (instead of metastasis) should be considered in patients with well differentiated thyroid carcinoma and anterior mediastinal radioiodine uptake.