• Title, Summary, Keyword: validation

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Validation of Sterilization Process (멸균제제공정의 Validation)

  • 김길수
    • YAKHAK HOEJI
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    • v.29 no.5
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    • pp.305-315
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    • 1985
  • Validation이란 용어는 1970년대에 우리나라에 GMP개념이 도입되면서 처음 사용되기 시작하여 지금은 흔히들 사용하면서도 그 개념은 아직도 정확히 이해되고 있지 않은것 같다. 제약공업에서의 validation의 적용범위는 아주 광범위하며 제조기기, 제조공정, 조직, 인원 등에 그 개념을 도입하여 관리하고 있다. 따라서 본 란에서는 validation의 일반적인 개념을 서술한 후 액상제제 특히 무균제제에 대한 calidation중 멸균공정에 대하여 상술하고자 한다.

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Candidate Points and Representative Cross-Validation Approach for Sequential Sampling (후보점과 대표점 교차검증에 의한 순차적 실험계획)

  • Kim, Seung-Won;Jung, Jae-Jun;Lee, Tae-Hee
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.31 no.1
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    • pp.55-61
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    • 2007
  • Recently simulation model becomes an essential tool for analysis and design of a system but it is often expensive and time consuming as it becomes complicate to achieve reliable results. Therefore, high-fidelity simulation model needs to be replaced by an approximate model, the so-called metamodel. Metamodeling techniques include 3 components of sampling, metamodel and validation. Cross-validation approach has been proposed to provide sequnatially new sample point based on cross-validation error but it is very expensive because cross-validation must be evaluated at each stage. To enhance the cross-validation of metamodel, sequential sampling method using candidate points and representative cross-validation is proposed in this paper. The candidate and representative cross-validation approach of sequential sampling is illustrated for two-dimensional domain. To verify the performance of the suggested sampling technique, we compare the accuracy of the metamodels for various mathematical functions with that obtained by conventional sequential sampling strategies such as maximum distance, mean squared error, and maximum entropy sequential samplings. Through this research we team that the proposed approach is computationally inexpensive and provides good prediction performance.

Improvement of Performance for Online Certificate Status Validation (실시간 인증서 상태검증의 성능개선)

  • Jung, Jai-Dong;Oh, Hae-Seok
    • The KIPS Transactions:PartC
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    • v.10C no.4
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    • pp.433-440
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    • 2003
  • According as the real economic activities are carried out in the cyber world and the identity problem of a trade counterpart emerges, digital signature has been diffused. Due to the weakness for real-time validation using the validation method of digital signature, Certificate Revocation List, On-line Certificate Status Protocol was introduced. In this case, every transaction workload requested to verify digital signature is concentrated of a validation server node. Currently this method has been utilized on domestic financial transactions, but sooner or later the limitation will be revealed. In this paper, the validation method will be introduced which not only it can guarantee real-time validation but also the requesting node of certificate validation can maintain real-time certificate status information. This method makes the revocation management node update the certificate status information in real-time to the validation node while revoking certificate. The characteristic of this method is that the revocation management node should memorize the validation nodes which a certificate holder uses. If a certificate holder connects a validation node for the first time, the validation node should request its certificate status information to the above revocation management node and the revocation management node memorizes the validation node at the time. After that, the revocation management node inform the revocation information in real-time to all the validation node registered when a request of revocation happens. The benefits of this method are the fact that we can reduce the validation time because the certificate validation can be completed at the validation node and that we can avoid the concentration of requesting certificate status information to a revocation node.

Delegated Attribute Certificate Validation And Protocol (PMI 인증서 검증 위임 및 검증 프로토콜)

  • 이승훈;송주석
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.13 no.1
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    • pp.59-67
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    • 2003
  • PMI(Privilege Management Infrastructure) certificates as well as Public-Key certificates must be validated before being used. Validation for a PMI certificate requires PMI certificate path validation, and PKC(Public-Key Certificate) path validations for each entity in the PMI certificate path. This validation work is quite complex and burdened to PMI certificate verifiers. Therefore, this paper suggests a delegated PMI certificate validation that uses specialized validation server, and defines a validation protocol which is used between validation server and client.

Bandwidth selections based on cross-validation for estimation of a discontinuity point in density (교차타당성을 이용한 확률밀도함수의 불연속점 추정의 띠폭 선택)

  • Huh, Jib
    • Journal of the Korean Data and Information Science Society
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    • v.23 no.4
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    • pp.765-775
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    • 2012
  • The cross-validation is a popular method to select bandwidth in all types of kernel estimation. The maximum likelihood cross-validation, the least squares cross-validation and biased cross-validation have been proposed for bandwidth selection in kernel density estimation. In the case that the probability density function has a discontinuity point, Huh (2012) proposed a method of bandwidth selection using the maximum likelihood cross-validation. In this paper, two forms of cross-validation with the one-sided kernel function are proposed for bandwidth selection to estimate the location and jump size of the discontinuity point of density. These methods are motivated by the least squares cross-validation and the biased cross-validation. By simulated examples, the finite sample performances of two proposed methods with the one of Huh (2012) are compared.

Basic Principles of the Validation for Good Laboratory Practice Institutes

  • Cho, Kyu-Hyuk;Kim, Jin-Sung;Jeon, Man-Soo;Lee, Kyu-Hong;Chung, Moon-Koo;Song, Chang-Woo
    • Toxicological Research
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    • v.25 no.1
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    • pp.1-8
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    • 2009
  • Validation specifies and coordinates all relevant activities to ensure compliance with good laboratory practices (GLP) according to suitable international standards. This includes validation activities of past, present and future for the best possible actions to ensure the integrity of non-clinical laboratory data. Recently, validation has become increasingly important, not only in good manufacturing practice (GMP) institutions but also in GLP facilities. In accordance with the guideline for GLP regulations, all equipments used to generate, measure, or assess data should undergo validation to ensure that this equipment is of appropriate design and capacity and that it will consistently function as intended. Therefore, the implantation of validation processes is considered to be an essential step in a global institution. This review describes the procedures and documentations required for validation of GLP. It introduces basic elements such as the validation master plan, risk assessment, gap analysis, design qualification, installation qualification, operational qualification, performance qualification, calibration, traceability, and revalidation.

A New Certificate Validation Scheme for Delegating the Digital Signature Verification (디지틀 서명 검증을 위임하기 위한 새로운 인증서 검증 기법)

  • Choi Yeon-Hee;Park Mi-Og;Jun Moon-Seog
    • Journal of Internet Computing and Services
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    • v.4 no.4
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    • pp.53-64
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    • 2003
  • To perform the certificate validation on the user-side application induces the very considerable overhead on the user-side system because of the complex and time-consuming characteristic of the validation processing. Most of the time spend for performing the validation processing is required for the digital signature verification, since the verification accompanies with the cryptographic calculation over each certificate on the certificate path. In this paper, we propose a new certificate validation scheme using DSVP(Delegated Signature Validation Protocol) which can reduce the overhead for the user-side certificate validation processing. It is achieved by delegating the digital signature verification to CAs of the PKI domain. As the proposed DSVP is the protocol performed between a user and CAs, it is applied to the hierarchical PKI efficiently and used for delegating the digital signature verification reliably and safely, our proposed scheme can not only reduces the overhead for the validation processing by decreasing the cryptographic calculation but also improves the utilization of CAs by employing them to the validation processing.

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Mean-Variance-Validation Technique for Sequential Kriging Metamodels (순차적 크리깅모델의 평균-분산 정확도 검증기법)

  • Lee, Tae-Hee;Kim, Ho-Sung
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.34 no.5
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    • pp.541-547
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    • 2010
  • The rigorous validation of the accuracy of metamodels is an important topic in research on metamodel techniques. Although a leave-k-out cross-validation technique involves a considerably high computational cost, it cannot be used to measure the fidelity of metamodels. Recently, the mean$_0$ validation technique has been proposed to quantitatively determine the accuracy of metamodels. However, the use of mean$_0$ validation criterion may lead to premature termination of a sampling process even if the kriging model is inaccurate. In this study, we propose a new validation technique based on the mean and variance of the response evaluated when sequential sampling method, such as maximum entropy sampling, is used. The proposed validation technique is more efficient and accurate than the leave-k-out cross-validation technique, because instead of performing numerical integration, the kriging model is explicitly integrated to accurately evaluate the mean and variance of the response evaluated. The error in the proposed validation technique resembles a root mean squared error, thus it can be used to determine a stop criterion for sequential sampling of metamodels.

Validation Technique using variance and confidence interval of metamodel (근사모델의 분산과 신뢰구간을 이용한 모델의 정확도 평가법)

  • Han, In-Sik;Lee, Yong-Bin;Choi, Dong-Hoon
    • Proceedings of the KSME Conference
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    • pp.1169-1175
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    • 2008
  • The validation technique is classified with two methods whether to demand of additional experimental points. The method which requires additional experimental points such as RSME is actually impossible in engineering field. Therefore, the method which only use experimented points such as the cross validation technique is only available. But the cross validation not only requires considerable computational costs for generating metamodel each iterations, but also cannot measure quantitatively the fidelity of metamodel. In this research we propose a new validation technique for representative metamodels using an variance of metamodel and confidence interval information. The proposed validation technique computes confidence intervals using a variance information from the metamodel. This technique will have influence on choosing the accurate metamodel, constructing ensemble of each metamodels and advancing effectively sequential sampling technique.

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A Case Study on the Validation of the Rolling Stock Requirement Statement (철도차량 요구사항서 논증 활동 사례 연구)

  • Kim Jin-Ill;Kim Jin-Hoon
    • Journal of the Korea Institute of Military Science and Technology
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    • v.7 no.2
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    • pp.57-64
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    • 2004
  • A Requirement statement validation process is suggested which was established and applied to the rolling stock development project of the Korean Railway Research Institute. The validation process includes team organization, selection of validation criteria, development of validation template, education of team members, validation, construction of database and management of requirement change. Many defects in the specification of requirement were found to be associated with the problem of non-uniqueness, describing solution instead of problem, ambiguity and redundancy. This paper described detailed activities at each step of the validation process and lessons learned from these activities.