• Title, Summary, Keyword: xylene-induced ear edema

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Anti-inflammatory Effects of Turmeric (Curcuma longa L.) Extract on Acute and Chronic Inflammation Models (만성 및 급성 염증 모델에서 강황추출물의 효과)

  • Anandakumar, Senthilkumar;Joseph, Joshua Allan;Bethapudi, Bharathi;Agarwal, Amit;Jung, Eun-Bong
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.43 no.4
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    • pp.612-617
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    • 2014
  • Anti-inflammatory effects of turmeric (Curcuma longa L.) rich in polysaccharides, as well as free of curcuminoids and turmerones were investigated in acute and chronic inflammatory models. Activity against the acute phase of inflammation was evaluated in carrageenan-induced paw edema and xylene-induced ear edema models. The results showed that turmeric extract significantly decreased paw edema volume in the first and third hours after carrageenan injection ($P{\leq}0.05$). Turmeric extract at all dose levels also significantly inhibited xylene-induced ear edema formation ($P{\leq}0.05$). Activity against chronic inflammation was also evaluated in cotton pellet-induced granuloma model. Turmeric extract significantly ($P{\leq}0.05$) decreased the weight of granuloma tissue on cotton pellets in a dose-dependent manner when compared to the vehicle control. Thus, the findings of the study suggest that turmeric extract in effective against both acute and chronic inflammation.

Anti-nociceptive and anti-inflammatory effects of Geranii Herba (현지초(玄之草)의 진통(鎭痛) 및 항염증(抗炎症) 효과)

  • Ju, Mi-Sun;Jeong, Hyun-Uk;Kim, Hyo-Geun;Park, Gun-Hyuk;Youn, You-Suk;Kim, Young-Ock;Kim, Sun-Yeou;Oh, Myung-Sook
    • The Korea Journal of Herbology
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    • v.25 no.3
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    • pp.97-101
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    • 2010
  • Objectives : The present study investigated the anti-nociceptive and anti-inflammatory properties of the water extract of Geranii Herba (The stem and leaves of Geranium thunbergii Sieb. et Zucc.) in the animal models of pain and inflammation. Methods : We evaluated the anti-nociceptive and anti-inflammatory activities of Geranii Herba extract (GHE) using the writhing test, tail-flick test, carrageenan-induced paw edema and xylene-induced ear edema models. Two dose of GHE (100 and 1000 mg/kg) was administrated orally to the mice. Control group received normal saline and ibuprofen (50 mg/kg) was used as a positive control drug. Results : GHE 1000 mg/kg treated group showed an increased tail-flick response time in the tail-flick test and inhibitory effect on writhing syndrome induced by acetic acid. Treatment with GHE at the same dose inhibited ear edema induced by xylene and foot edema induced by carrageenan toxicity. Conclusion : The results demonstrate that GHE has anti-nociceptive and anti-inflammatory effects in the various models of nociception and inflammation.

Anti-Inflammatory Effect of 'Jungcheonhwadamgangki-tang'in Xylene-Application Mouse Ear Acute Inflammation Model (정서화담강기탕(定瑞化痰降氣湯)이 Xylene으로 유발된 마우스의 급성 염증에 미치는 영향)

  • Song, Muh-Sik;Jeon, Kwi-Ok;Park, Mee-Yeon;Choi, Hae-Yun;Kim, Jong-Dae;Cho, Dong-Hee
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.20 no.4
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    • pp.875-881
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    • 2006
  • In the present study, the anti-inflammatory effect of 'Jungcheonhwadamgangki -tang' water extract was tested in Xylene-Application mouse ear acute inflammation model. The test articles were once dosed before Xylene-Application, and the changes on body weight and ear weights and histopathological observation of induced ear were conducted with ear histomorphometry. The increases of absolute and relative ear weight detected in vehicle control compared to that of sham , were significantly and dose-dependently inhibited by Jungcheonhwadarn -gangki-tang in the present study. A classic acute inflammatory histological changes such as subcutaneous edema, hypertrophy and infiltration of inflammatory cells, was detected in vehicle control. However, these histological changes were significantly and dose-dependently inhibited by Jungcheonhwadam-gangki-tang. In addition, the increases of ear thickness half and thickness full detected in the vehicle control, were also dose-dependently decreased in the all Jungcheonhwadamgangki-tang-dosing groups. Base on these results, it is concluded that Jungcheonhwadamgangki-tang water extracts have clear anti-inflammatory effect on the acute inflammation, and about 500 mg/kg of Jungcheonhwadamgangki-tang water extracts have similar effect compared to that of Dicrofenac 15 mg/kg.

Anti-Inflammatory Effect of Jungcheonhwadamgangki-tang ga Antler in Xylene-Application Mouse Ear Acute Inflammation Model (정천화담강기탕가녹용(定喘化痰降氣湯加鹿茸)이 Xylene으로 유발된 마우스의 급성 염증에 미치는 영향)

  • Cho, Dong-Hee;Son, Ji-Young;Lee, Yeon-Kyeong;Choi, Kyu-Ho;Park, Mee-Yeon;Choi, Hae-Yun;Kim, Jong-Dae
    • Herbal Formula Science
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    • v.15 no.2
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    • pp.99-111
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    • 2007
  • In the present study, the anti-inflammatory effect of "Jungcheonhwadamgangki-tang ga Antler" water extract was tested in Xylene-Application mouse ear acute inflammation model. The test articles were once dosed before Xylene-Application, and the changes on body weight and ear weights and histopathological observation of induced ear were conducted with ear histomorphometry. The obtained results were as follows. The increases of absolute and relative ear weight detected in vehicle control compared to that of sham, were significantly and dose-dependently inhibited by Jungcheonhwadamgangki-tang ga Antler in the present study. A classic acute inflammatory histological changes such as subcutaneous edema, thickness and infiltration of inflammatory cells, was detected in vehicle control. However, these histological changes were significantly and dose-dependently inhibited by Jungcheonhwadamgangki-tang ga Antler. In addition, the increases of ear thickness half and thickness full detected in the vehicle control were also dose-dependently decreased in the all Jungcheonhwadamgangki-tang ga Antler-dosing groups. Base on these results, it is concluded that Jungcheonhwadamgangki-tang ga Antler extracts has clear anti-inflammatory effect on the acute inflammation such as bronchial asthma.

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Anti-Inflammatory Effect of Haepyoejin-tang plus Antler water extract in Xylene-Application Mouse Ear Acute Inflammation Model (해표이진탕가녹용(解表二陳湯加鹿茸)이 Xylene으로 유발된 마우스의 급성 염증에 미치는 영향)

  • Jung, Bong-Gyun;Jeon, Kwi-Ok;Park, Mee-Yeon;Choi, Hae-Yun;Kim, Jong-Dae;Cho, Dong-Hee
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.20 no.4
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    • pp.985-991
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    • 2006
  • In the present study, the anti-inflammatory effect of Haepyoeiin-tang plus Antler water extract water extract was tested in Xylene-Application mouse ear acute inflammation model. The test articles were once dosed before Xylene-Application, and the changes on Dody weight and weights and histopathological observation of induced ear were conducted with ear histomorphometry, The increases of absolute and relative ear weight detected in vehicle control compared to that of sham, were significantly and dose-dependently inhibited by Haepyoejin-tang plus Antler in the present study, A classic acute inflammatory histological changes such as subcutaneous edema, hypertrophy and infiltration of inflammatory cells, was detected in vehicle control. However, these histological changes were significantly and dose-dependently inhibited by Haepyoeiin-tang plus Antler. In addition, the increases of ear thickness half and thickness full detected in the vehicle control, were also dose-dependently decreased in the all Haepyoeiin-tang plus Antler-dosing groups. Base on these results, it is concluded that Haepyoeiin-tang plus Antler water extracts have a clear anti-inflammatory effect on the acute inflammation. However, somewhat lower anti-inflammatory effects were detected in Haepyoeiin-tang plus Antler water extracts compare to that of Dethamethason and Dicrofenac. About 500 mg/kg of Haepyoeiin-tang plus Antler water extracts have similar effect compared to that of Dicrofenac 15 mg/kg.

Antioxidant and Anti-inflammatory Effects of Ethanol Extracts from Perilla frutescens (들깨(Perilla frutescens) 새싹 추출물의 항산화 및 항염 효과)

  • Jeong, Seung-Il;Kim, Hyeon Soo;Jeon, In Hwa;Kang, Hyun Ju;Mok, Ji Ye;Cheon, Chun Jin;Yu, Hyeon Hee;Jang, Seon Il
    • Korean Journal of Food Science and Technology
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    • v.46 no.1
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    • pp.87-93
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    • 2014
  • We investigated the effects of an ethanol extract from Perilla frutescens sprouts (PFSE) as an antioxidant, and its effects on edema and inflammation in RAW 264.7 cells and HMC-1 cells. The antioxidant activities (DPPH and ABTS radical scavenging) of PFSE were similar to those of butylated hydroxytoluene (BHT) and (${\pm}$)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox). We also investigated the anti-inflammatory effects of PFSE on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and HMC-1 cells stimulated with phorbol 12-myristate 13-acetate (PMA) with the calcium ionophore A23187. TNF-${\alpha}$ and IL-$1{\beta}$ production, which had been increased by treatment with LPS or PMA plus A23187, were significantly inhibited by PFSE in a dose-dependent manner. Furthermore, PFSE significantly reduced the xylene-induced ear edema and the carrageenan-induced paw edema of ICR mice in a dose-dependent manner. The effects of PFSE (200 mg/kg) in reducing ear and paw edema were similar to those of aspirin (50 mg/kg). These results suggest that PFSE can be potentially used as a medicine for treating oxidative stress, an edematous and inflammatory disease.

Effect of Mulberry Extract Complex on Degenerative Arthritis In Vivo Models (In Vivo 실험모델에서 오디추출복합물의 퇴행성관절염 개선 효능 연구)

  • Li, Hua;Yun, Sat-Byul;Shin, So Hee;Jeong, Jong-Moon
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.45 no.5
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    • pp.634-641
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    • 2016
  • The objective of this research was to investigate the in vivo effects of treatment with mulberry extract complex (MEC) on cartilage degeneration and pain severity in an experimental model of rat degenerative arthritis. Monosodium iodoacetate ($2mg/50{\mu}L$) was injected into right knee joints of rats, followed by administration of MEC for 8 weeks at 400 mg/kg or 800 mg/kg of body weight. The experimental data show that treatment with MEC inhibited degradation of glycosaminoglycan and collagen in cartilage. On the other hand, concentrations of cartilage oligomeric matrix protein, C-terminal telopeptide-2, matrix metalloproteinase (MMP)-2, MMP-9, and MMP-13 in serum decreased in comparison with the control. The MEC at all dose levels could inhibit formation of xylene-induced ear edema. In this study, MEC demonstrated significant anti-arthritis activity, which is required for improvement of degenerative arthritis. Based on these results, MEC may be employed for the development of new health foods to ease symptoms of degenerative arthritis.