The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Anti-aging Effect on Skin with Jaeum-Dan (JED)

滋陰丹이 皮膚의 老化에 미치는 影響

Park Seong-Kyu;Kim Soo-Nam;Lee, Jong-Chan;Kim Han-Sung;Kim Youn-Joon;Lee, Byeong-Gon;Chang Ih-Seoup
박성규;김수남;이종찬;김한성;김연준;이병곤;장이섭

  • Published : 20040000

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Abstract

Objectives: Jaeum-Dan (JED) I and II are new formulas composed with oriental herbs. We investigated the anti-aging effects on skin with water extracts of JED 1 , JED II, JJZD IIJ and each Bupleuri Radix, Lonicerae Caulis, Coicis Semen, Armeniacae Amarum Semen, Plantaginis Herba. Methods: We measured various effects related to skin such as the proliferation of keratinocytes, the inhibition of reactive oxygen species (ROS) generation, 5a-reductase activity, the gap junctional intercellular communication, the amount of melanin and the synthesis of MMP-1 and type I procollagen. Results: The proliferation of keratinocytes were increased in JED I , 11, ID and water extracts of Bupleun Radix, Plantaginis Herba. The production of ROS were decreased in JED I , II, IJl and water extract of Bupleun Radix. 5$\alpha$-reductase activity were decreased in JED I , II, lII and water extract of Lonicerae Caulis. Gap junctional intercellular communcation were increased to normal level in water extract of Coicis Semen. The amount of melanin were decreased in JED I , II, IU and water extract of Armeniacae Amarum Semen, Plantaginis Herba. The synthesis of MMP-1 and type I procollagen were positive in JED I , II, ID and water extract of Plantaginis Herba. Conclusions: The results of our study indicate that each 5 herbs have anti-aging effects and the complex of JED I with rl were best in anti-aging effects on skin.

Keywords

References

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