The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Neuroprotective Effect of Rhodiola sachalinensis Extracts on Transient Focal Cerebral Ischemia in Rats

紅景天의 흰쥐 일시적 국소뇌허혈에 대한 신경방어효과

Bu Yungmin;Baek Sunkyung;Jin Zhen Hua;Kang Tongho;Rho Seungju;Kim Hocheol
부영민;백선경;김진화;강동호;노승주;김호철

  • Published : 20040000

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Abstract

Objectives: The root of Rhodiola sachalinensis A. bar (RS), which has been used to strengthen qi (補氣), reduce heat of lung (淸肺), nourish heart (養心), stop bleeding (止血), reduce edema (消腫) for the treatment of fatigue, amnesia, bleeding and edema. It's flavour and channel tropism is sweet (甘), acting on the lung (肺). The purpose of the study we report here was to determine the neuroprotective effect of the roots of RS on transient focal cerebral ischemia in SD rats. Methods: The root of RS was lyophilized after extraction with $85\%$ methanol. We occluded middle cerebral artery for 90 minutes and reperfused for 24 hours. The brain slices were stained by $2\%$ 2, 3, 5-triphenyltetrazolium chloride and the infarct volume was measured by graphic analyzer. Results: The noot extracts of RS showed significant neuroprotective effects (100 mg/kg, p<0.05) compared with control group. The neuroprotective efficacy was about $35\%$. Immunohistochemical data explained the protective effects of RS via attenuation of COX-2 induction in neocortex and inhibition of microglia activation in the penumbral region. Conclusions: The root of RS has neuroprotective effects on transient focal cerebral ischemia in Spargue-Dawley rats and the mechanism might be the attenuation of COX-2 induction and microglial acti vation.

Keywords

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