Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Antioxidant and Anti-wrinkle Effects of Steamed Three Ginseng Extracts

숙성된 3종 인삼추출물의 항산화 및 주름개선 효과

  • Kim, Min-Jeong (Department of biotechnology, College of Medical Life Science, Silla University) ;
  • Kwon, Ryun-Hee (Department of biotechnology, College of Medical Life Science, Silla University) ;
  • Jang, Min-Woo (Department of biotechnology, College of Medical Life Science, Silla University) ;
  • Ha, Bae-Jin (Department of biotechnology, College of Medical Life Science, Silla University)
  • 김민정 (신라대학교 일반대학원 생명공학과) ;
  • 권륜희 (신라대학교 일반대학원 생명공학과) ;
  • 장민우 (신라대학교 일반대학원 생명공학과) ;
  • 하배진 (신라대학교 일반대학원 생명공학과)
  • Received : 2012.03.23
  • Accepted : 2012.06.20
  • Published : 2012.06.30
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Abstract

Steamed ginseng is well known as a tonic medicine for restoring and enhancing human health. Steamed ginseng had more pharmacologically activity than white ginseng. The effects of steamed ginseng on transplantable tumors, proliferation of lymphocyte and rat liver lipid peroxidation were studied. This study was performed to evaluate the antioxidation and antiwrinkle effects of three ginseng extracts. Raw ginseng (RGS) and dried ginseng (DGS) mature like red ginseng in addition to the ready-made red ginseng (GS) purchased in the market, were steamed and extracted by red ginseng extractor. Three extracts of steamed ginseng were investigated to determine effects of superoxide radical scavenging activity, hydroxyl radical scavenging activity, autooxidation inhibition of linoleic acid, collagenase inhibition and collagen synthesis in normal fibroblast. RGS showed not only the highest superoxide radical scavenging activity at a concentration of 100 ug/mL but also the hydroxyl radical scavenging activity higher than vitamin C. Also RGS showed the highest activity in inhibition of autooxidation of linolic acid, collagen synthesis, and collagenase inhibition.

숙성된 인삼은 인간의 건강을 회복시키고 향상시키는 강장제로서 알려져 있으며, 백삼보다 더 많은 약리적인 활성을 가진다고 알려져 왔다. 전이 가능한 종양, 림프구 증식과 쥐간의 지질과산화에 대한 숙성된 인삼의 효과도 연구되었다. 본 연구는 3가지 인삼 추출물의 항산화와 항노화 효과를 평가하기 위해서 실험하게 되었다. 시장에서 이미 만들어진 홍삼엑기스를 사용하였고, 그 외 수삼, 건삼을 구매하여 홍삼제조기로 만들어진 추출물로 실험에 사용하였다. 숙성된 인삼의 3가지 추출물들은 superoxide radical 소거 활성, hydroxyl radical 소거 활성, 리놀산 자동산화 억제, 섬유아세포에서 collagenase 억제와 collagen 합성의 효과를 연구했다. 숙성시켜 만든 수삼은 100 ug/mL의 농도에서 가장 높은 superoxide radical 소거 활성뿐만 아니라 vitamin C보다 더 높은 hydroxyl radical 소거 활성을 나타냈다. 또한 리놀산 자동산화 억제, collagen 합성과 collagenase 억제에서 가장 높은 활성을 보였다.

Keywords

References

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