Historical Controls, Data Banks, and Randomized Trials in Clinical Research: A Review

  • Fleming Thomas R. (Department of Medical Statistics and Epidemiology, Mayo Clinic and Mayo Foundation)
  • Published : 1994.02.01

Abstract

A brief review is presented of the strengths and weaknesses of historical controls, data banks, and randomized trials in the evaluation of clinical treatment. Use of pre randomized versus postrandomized informed consent is discussed. Recommendations are made for the development of an appropriate clinical research strategy.

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