A study on the Modeling of Nonlinear Properties of Biological Signal using Genetic Programming

유전자 프로그래밍을 이용한 생체 신호의 비선형 특성 모델링에 관한 연구

Many researchers had considered biological systems as linear systems. In many cases of biological systems, the phenomena that show the regular and periodic dynamics are considered the normal state. However, some clinical experiments reported, in some cases, the periodic signals represented the abnormal state. We assume that signals from human body system are generated from deterministic, intrinsic mechanisms and can be represented a simple equation that show nonlinear dynamics dependent on control parameters. The objective of our study is to model a nonlinear dynamics correctly from the nonlinear time series using the genetic programming method; to find a simple equation of nonlinear dynamics using collected time series and its nonlinear characteristics. We applied genetic programming to model RR interval of ECG that shows chaotic phenomena. We used 4 statistic measures and 2 fractal measures to estimate fitness of each chromosome, and could obtain good solutions of which chaotic features are similar.