Proceedings of the KOSOMBE Conference (대한의용생체공학회:학술대회논문집)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Pulsatile Interpenetrating Polymer Networks Hydrogels Composed of Poly(vinyl alcohol) and Poly(acrylic acid) ; Synthesis, Characterization, and its Application to Drug Delivery Systems

  • Shin, Heung-Soo (Department of Industrial Chemistry, College of Engineering, Hanyang University) ;
  • Kim, So-Yeon (Department of Industrial Chemistry, College of Engineering, Hanyang University) ;
  • Lee, Young-Moo (Department of Industrial Chemistry, College of Engineering, Hanyang University)
  • Published : 1996.11.15
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Abstract

Pulsatile swelling behaviors and their application to drug delivery system were studied by using interpenetrating polymer networks(IPN) hydrogels constructed with poly(vinyl alcohol) and poly(acrylic acid). The PVA/PAAc IPNs hydrogels were symthesized by UV irradiation tallowed by repetitive freezing and thawing method. These hydrogels showed pH and temperature sensitive swelling behaviors. From the release experiment, the release amount of model drug incorporated into these hydrogels showed pulsatile patterns. Permeability coefficients obtained by various solutes differed in response to changes of permeation conditions.

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