Proceedings of the KOSOMBE Conference (대한의용생체공학회:학술대회논문집)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Distribution Mapping and Local Analysis of Ciliary Beat Frequencies

세포의 섬모 운동 변화 분석을 위한 CBF 분포도 구성 및 국소적 분포 분석에 관한 연구

  • Yi, W.J. (Interdisciplinary Program in Medical and Biological Engineering Major, Seoul Nat'l Univ.) ;
  • Park, K.S. (Dept. of Biomedical Engineering, College of Medicine, Seoul Nat'l Univ.) ;
  • Min, Y.G. (Dept. of Rhino-Laryngology, College of Medicine, Seoul Nat'l Univ.) ;
  • Sung, M.W. (Dept. of Rhino-Laryngology, College of Medicine, Seoul Nat'l Univ.) ;
  • Lee, K.S. (Dept. of Rhino-Laryngology, College of Medicine, Seoul Nat'l Univ.)
  • 이원진 (서울대학교 대학원 협동과정 의용생체공학) ;
  • 박광석 (서울대학교 의과대학 의공학 교실) ;
  • 민양기 (서울대학교 의과대학 이비인후과학 교실) ;
  • 성명훈 (서울대학교 의과대학 이비인후과학 교실) ;
  • 이강수 (서울대학교 의과대학 이비인후과학 교실)
  • Published : 1997.11.28
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Abstract

By their rapid and periodic actions, the cilia of the human respiratory tract play an important role in clearing inhaled noxious particles. Based on the automated image-processing technique, we studied ciliary beat frequency (CBF) objectively and quantitatively. Microscopic ciliary images were transformed into digitized gray ones through an image-grabber, and from these we extracted signals or CBF. By means of a FFT, maximum peak frequencies were detected as CBFs in each partitioned block or the entire digitized field. With these CBFs, we composed distribution maps visualiy showing the spatial distribution of CBFs. Through distribution maps of CBF, the whole aspects of CBF changes or cells and the difference of CBF of neighboring cells can be easily measured and detected. Histogram statistics calculated from the user-defined polygonal window can show the local dominant frequency presumed to be the CBF of a cell or a crust the region includes.

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