Proceedings of the KOSOMBE Conference (대한의용생체공학회:학술대회논문집)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Study of the capability of metallic coils immersed with protein solution as embolic masterials

색전용 금속 코일 개발과 단백질 처리 후 혈전성에 대한 연구

  • Lee, Y.S. (Institute of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Kim, T.S. (Dept. of Radiology, College of Medicine, Seoul National University) ;
  • Kim, H.C. (Dept. of Radiology, College of Medicine, Seoul National University) ;
  • Shin, K.M. (Dept. of Radiology, College of Medicine, Seoul National University) ;
  • Park, J.H. (Dept. of Radiology, College of Medicine, Seoul National University)
  • 이윤신 (서울대학교 의과대학 의공학연구소) ;
  • 김태성 (서울대학교 의과대학 진단방사선과) ;
  • 신경민 (서울대학교 의과대학 진단방사선과) ;
  • 김호철 (서울대학교 의과대학 진단방사선과) ;
  • 박재형 (서울대학교 의과대학 진단방사선과)
  • Published : 1997.11.28
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Abstract

In this study, we designed a vascular occlusion device based on the principle that slowing blood flow would induce thrombosis. Tungsten, stainless steel and platinum were tested for finding a good embolic metallic coil. The primary coil and the second coil were done with heat treatment or different time. The pitch distance and the shape retention capability of second coil were characterized by SEM. To increase thrombogenicity, we tried to treat different proteins on steel coils: thrombin, gelatin and both gelatin and thrombin. To verify protein materials treated on coils, the surface of coil treated with different proteins were characterized using Laser Raman Spectrophotometer. After observation of embolic coils, the peptides bonds on theirs' surface were found. In order to compare the thrombogenicity of different embolic agents, we measured whole blood clotting time.

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