Proceedings of the KOSOMBE Conference (대한의용생체공학회:학술대회논문집)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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In Vivo Measurement of Ciliary Beat Frequency in Human Nasal Ciliated Epithelium Cells Using a Laser Light Scattering and AR Power Spectrum

레이저 산란 측정법과 AR 파워 스펙트럼 방법을 이용한 생체 내 섬모운동 주파수 측정 및 분석에 관한 연구

  • Yi, Won-Jin (Interdisciplinary Program in Medical and Biological Engineering Major, Seoul National Univ.) ;
  • Park, Kwang-Suk (Dept. of Biomedical Engineering, College of Medicine, Seoul National Univ.) ;
  • Yun, Ja-Bok (Dept. of Otolaryngology, College of Medicine, Seoul National Univ.) ;
  • Min, Yang-Gi (Dept. of Otolaryngology, College of Medicine, Seoul National Univ.)
  • 이원진 (서울대학교 대학원 협동과정 의용생체공학) ;
  • 박광석 (서울대학교 의과대학 의공학 교실) ;
  • 윤자복 (서울대학교 의과대학 이비인후과학 교실) ;
  • 민양기 (서울대학교 의과대학 이비인후과학 교실)
  • Published : 1998.11.20
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Abstract

The mucociliary system is one of the most important airway defense mechanisms, and knowledge of the ciliary beat frequency(CBF) is important in the understanding of this system. Using a laser light scattering method and fiber optic probe, we developed a simple and practical instrument for real-time in vivo measurements of CBF of cells in human nasal cavity. From the ciliated epithelium cells in an anterior end of middle terminator in nasal cavity, the signals of ciliary movement are transferred into a PC and analyzed by a autoregressive(AR) power spectrum. The mean CBF of 8 normal subjects was $7.1{\pm}1.1$(Hz). This instrument provided a convenient and reliable method of studying the mucociliary activity in the respiratory tract.

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