Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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8-Hydroxyguanine in DNA Mediates Cell Death of KG-1, a Human Leukemia Cell Line by Inducing Cell Cycle Arrest and Apoptosis

  • Hyun, Jin-Won (Department of Pharmacology, Seoul National University College of Medicine)
  • Published : 2001.05.01
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Abstract

All that is presently known about the actions of 8-hydroxyguanine (8-oxoguanine; oh$^{8}$ Gua) in DNA is that it harms genetic integrity. This is even speculation based upon scattered in vitro experimental data such as the mismatch of oh$^{8}$ Gua with A in stead of C and the GC longrightarrow TA transversion observed in the DNA polymerase reaction using an oh$^{8}$ Gua containing oligonucleotide.(omitted)

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