THE ESSENTIAL ROLE OF PHOSPHATIDYLINOSITOL 3-KINASE IN THE INDUCTION OF MICROSOMAL EPOXIDE HYDROLASE

  • Kang, Keon-Wook (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Ryu, Ji-Hwa (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Kim, Sang-Geon (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
  • Published : 2001.05.01

Abstract

We have shown that PI3-kinase played an essential role in the ARE-mediated rGSTA2 induction by oxidative stress following sulfur amino acid deprivation (SAAD) (Kang et al., Mol. Pharmacol., 2000). Microsomal epoxide hydrolase (mEH), which detoxifies a variety of epoxide intermediates produced from various xenobiotics, is inducible by oxidative stress.(omitted)

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