Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.05a
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- Pages.140-140
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- 2001
THE ESSENTIAL ROLE OF PHOSPHATIDYLINOSITOL 3-KINASE IN THE INDUCTION OF MICROSOMAL EPOXIDE HYDROLASE
- Kang, Keon-Wook (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
- Ryu, Ji-Hwa (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
- Kim, Sang-Geon (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
- Published : 2001.05.01
Abstract
We have shown that PI3-kinase played an essential role in the ARE-mediated rGSTA2 induction by oxidative stress following sulfur amino acid deprivation (SAAD) (Kang et al., Mol. Pharmacol., 2000). Microsomal epoxide hydrolase (mEH), which detoxifies a variety of epoxide intermediates produced from various xenobiotics, is inducible by oxidative stress.(omitted)
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