Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.05a
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- Pages.141-141
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- 2001
THE EFFECT OF COPROPHAGY ON THE EXPRESSION OF HEPATIC CYP2E1 DURING STARVATION
- Chung, Hye-Chin (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
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Sung, Sang-Hyun
(College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
;
- Kim, Jin-Soo (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
- Kim, Young-Choong (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
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Kim, Sang-Geon
(College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
- Published : 2001.05.01
Abstract
Starvation stimulates multiple signaling pathways, which lead to extensive metabolic alterations Starvation potentiates the hepatotoxicity of a variety of small molecules including chlorinated hydrocarbons and nitrosamines through the induction of CYP2E1. A change in CYF2E1 expression during starvation may also alter the pharmacokinetic profiles of xenobiotics.(omitted)
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