Response surface method is applied to evaluate the reliability of laminated composite panels. Since the linear and nonlinear first-ply failure load are computed using deterministic finite element analysis, new probabilistic finite element analysis is not necessary. Tsai-Wu criterion is used to construct the limit state suface. Material properties, layer thickness and lamina strengths of laminated composite panel are treated as random design variables. feasibility and accuracy of current method is validated using Monte-Carlo method Which perform thousand times of finite element analysis directly.