Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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DOWN-REGULATION OF RAF-1 KINASE IS ASSOCIATED WITH PACLITAXEL RESISTANCE IN HUMAN BREAST CANCER MCF-7/ADR CELLS

  • Lee, Michael (Korea Institute of Toxicology, KRICT) ;
  • Jung Kwon (Korea Institute of Toxicology, KRICT) ;
  • Wayne B. Anderson (Laboratory of Cellular Oncology, NCI, NIH, Bethesda) ;
  • Chung, Moon-Koo (Korea Institute of Toxicology, KRICT)
  • Published : 2002.11.01
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Abstract

Experiments were carried out to determine the role of Raf-1 kinase in the development of drug resistance and apoptosis induced by paclitaxel. In the present study, paclitaxel sensitivity, Raf-1 activity and MAPKs activation were compared in 2 cell lines: parental human breast cancer cells and its drug resistant variant (MCF-7/Adr) cells.(omitted)

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