ROLES OF MAPK PATHWAYS IN GDNF-INDUCED GLIOMA CELL MIGRATION

  • Published : 2002.11.01

Abstract

Glial cell-derived neurotrophic factor (GDNF) is a potent neurotrophic factor that enhances survival of midbrain doparminergic neuron and is a member of the transforming growth factor-b superfamily. GDNF and its receptors are widely distributed in brain and are believed to be involved in the control of neuron survival, proliferation and differentiation.(omitted)

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