Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Effect of capsaicin on melanoma growth and metastasis

  • Kim, Ok-Hee (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Jun, Hye-Seung (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Han, Beom-Seok (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Song, Chi-Won (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Lee, Chang ki (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Park, Mi-Sun (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Eom, Mi-Ok (Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Jee, Seung-Wan (Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Ryeom, Tai-Kyung (Institute of Toxicological Research, Korea Food and Drug Administration)
  • Published : 2002.11.01
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Abstract

Capsaicin (8-methyl-N-vanillyl-6-nonenamide), a pungent ingredient of hot chili peppers, has been reported to possess substantial anticarcinogenic and antimutagenic activities. In our previous study, we found that capsaicin (100 ${\mu}$M) induced significant inhibition of matrix metalloproteinase-2 activity by gelatin zymography, and that capsaicin (i.p., 2.5mg/kg) inhibited development of lung colonization (58%) in experimental lung metastasis assay.(omitted)

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