한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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- Pages.152-152
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- 2002
COX-INHIBITORS DOWN-REGULATE TCDD-INDUCED cyp1a1 ACTIVITY IN C57BL/6 MOUSE AND Hepa- I CELLS
- Syrie Bang (College of Pharmacy, Ewha Womans University) ;
- Cho, Min-Jung (College of Pharmacy, Ewha Womans University) ;
- Sheen, Yhun-Yhong (College of Pharmacy, Ewha Womans University)
- 발행 : 2002.11.01
초록
In order to understand the mechanism of action of TCDD, we have examined the effect of COX-inhibitors on cyplal activity. We observed the effect of COX-inhibitor on EROD activity in C57BL/6 mouse in vivo. And we also evaluated the effect of COX-inhibitors on cyplal mRNA, mouse cyp1a1 promoter activity and EROD activity in Hepa cell.(omitted)