한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)

한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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The induction of Micronucleus and Aneuploidy in human lymphocytes by Hydroquinone and its association with Genetic Polymorphisms of CYP1A1, GSTM1, GSTT1, NQO1 gene

  • Chung, Eun-Jung (School of Public Health, Seoul National University) ;
  • Kim, Tae-Yon (School of Public Health, Seoul National University) ;
  • Kim, Jin-Sik (School of Public Health, Seoul National University) ;
  • Kim, Yang-Ji (School of Public Health, Seoul National University) ;
  • Cho, Yoon-Hee (School of Public Health, Seoul National University) ;
  • Chung, Hai-Won (School of Public Health, Seoul National University)
  • 발행 : 2002.11.01
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초록

In order to investigate whether the induction of micronucleus and aneuploidy in human lymphocytes by Hydroquinone (HQ) is associated with genetic polymorphisms of CYP1A1, GSTM1, GSTT1, NQO1 gene, the cytokinesis-block micronucleus (CBMN) assay in combination with fluorescence in situ hybridization (FISH) technique using specific centromeric probes for chromosome 7 and 8 and PCR-RFLP based genotyping for 30 healthy people were performed.(omitted)

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