한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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- Pages.191-191
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- 2002
REGULATION OF BETA-AMYLOID-STIMULATED PRO INFLAMMATORY RESPONSES VIA MITOGEN ACTIVATED PROTEIN KINASES AND REDOX SENSITIVE TRANSCRIPTION FACTORS
- Hee, Jang-Jung (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University) ;
- Joon, Surh-Young (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University)
- 발행 : 2002.11.01
초록
Inflammatory as well as oxidative tissue damage has been associated with pathophysiology of Alzheimer's disease (AD), and nonsteroidal anti-inflammatory drugs have been shown to retard the progress of AD. In this study, we have investigated the molecular mechanisms underlying oxidative and inflammatory cell death induced by beta-amyloid (Abeta), a neurotoxic peptide associated with senile plaques formed in the brains of patients with AD, in cultured PC12 cells.(omitted)