Proceedings of the SCSK Conference (대한화장품학회:학술대회논문집)
- 2003.09b
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- Pages.174-183
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- 2003
New candidate for skin depigmentation: The inhibitory effect and cytotoxicity of small molecule compounds at in vitro cell culture
- Rho, H.S (R&D center, AmorePacific Corporation) ;
- Kim, K.J. (R&D center, AmorePacific Corporatio) ;
- Hwang, J.S. (R&D center, AmorePacific Corporatio) ;
- H.J., Shin (R&D center, AmorePacific Corporatio) ;
- Chang, H.K. (R&D center, AmorePacific Corporatio) ;
- Chang, I.S. (R&D center, AmorePacific Corporatio) ;
- Lee, O.S. (R&D center, AmorePacific Corporation)
- Published : 2003.09.01
Abstract
To obtain effective and safe topical depigmenting agents, we synthesized hydroxybenzoates, alkoxybenzoates, and 3,4,5-trimethoxycinnamate containing a thymol moiety and screened then for high-level inhibitory activity against melanin synthesis. Among them, 5-methyl-2-(methylethyl)phenyl (2Ε)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate (Melasolv)