Silica Induces Nuclear Factor-kB Activation through TAK1 and NIK in Rat2 cell line

  • Young Lim (Department of Occupational and Environmental Medicine) ;
  • Nam, Hae-Yun (College of Medicine, The Catholic University of Kore) ;
  • Rha, Suk-Joo (Research Institute of New Drug Developmen) ;
  • Kim, Young-Hoon (Research Institute of New Drug Developmen) ;
  • Cho, Yong-Yeun (Korea Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Yang, Ki-Hwa (Korea Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Kim, Kyoung-Ah (Department of Occupational and Environmental Medicin) ;
  • Lee, Kweon-Haeng (Research Institute of New Drug Development)
  • Published : 2003.05.01

Abstract

Silica has been known to be a factor in acute cell injury and chronic pulmonary fibrosis. In Rat2 fibroblasts, silica induced the activation of NFkB, which plays a crucial role in regulating the expression of many genes involved in the subsequent inflammatory response. In addition, we observed that TAK1 and NIK were involved in silica-mediated NF-kB activation in Rat2 cells. (omitted)

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